Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

2016年第10卷第2期

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《化学科学与工程前沿（英文）》 >> 2016年第10卷第2期 doi: 10.1007/s11705-016-1565-3

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

. Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.. Howard Hughes Medical Institute, Department of Molecular Biology, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.. College of Life Sciences, Sichuan University, Chengdu 610041, China

录用日期： 2016-04-08 发布日期： 2016-05-19

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摘要

X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleic acids and protein-nucleic acid complexes. However, the crystallization and phase determination are the major bottle-neck problems in crystallography. Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids (SeNA) for nucleic acid crystallography. SeNA might not only provide the rational strategies to solve the phase determination problem, but also offer a potential strategy to explore crystallization solutions.

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selenium ; DNA ; RNA ; nucleic acid ; crystallization