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2017年 第11卷 第1期

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《化学科学与工程前沿（英文）》 >> 2017年 第11卷 第1期 doi: 10.1007/s11705-016-1591-1

Cofactor engineering in cyanobacteria to overcome imbalance between NADPH and NADH: A mini review

. Department of Chemical Engineering, Pohang University of Science and Technology, Gyeongbuk 790-784, Korea.. School of Environmental Science and Engineering, Pohang University of Science and Technology, Gyeongbuk 790-784, Korea.. Division of Advanced Nuclear Engineering, Pohang University of Science and Technology, Gyeongbuk 790-784, Korea

录用日期： 2016-09-18 发布日期： 2017-03-17
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Cyanobacteria can produce useful renewable fuels and high-value chemicals using sunlight and atmospheric carbon dioxide by photosynthesis. Genetic manipulation has increased the variety of chemicals that cyanobacteria can produce. However, their uniquely abundant NADPH-pool, in other words insufficient supply of NADH, tends to limit their production yields in case of utilizing NADH-dependent enzyme, which is quite common in heterotrophic microbes. To overcome this cofactor imbalance and enhance cyanobacterial fuel and chemical production, various approaches for cofactor engineering have been employed. In this review, we focus on three approaches: (1) utilization of NADPH-dependent enzymes, (2) increasing NADH production, and (3) changing cofactor specificity of NADH-dependent enzymes from NADH to NADPH.

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