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《工程(英文)》 >> 2020年 第6卷 第1期 doi: 10.1016/j.eng.2019.08.014

首次从猪体内分离鉴定人苍白杆菌

a National Research Center for Veterinary Medicine, Luoyang 471000, China
b College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
# These authors contributed equally to this work.

收稿日期 :2019-03-18 修回日期 :2019-07-31 录用日期 : 2019-08-02 发布日期 :2019-10-25

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摘要

从具有神经症状的临床发病猪的脑中分离出一株革兰氏阴性杆菌,该猪脑组织病理检查结果显示有脑膜炎。从大脑样本中成功分离的这株菌经生化反应(API 20 NE)鉴定为人苍白杆菌(O. anthropi ),并通过基因测序进行了确证。该菌株对β -内酰胺类抗生素高度耐药。用该O. anthropi 分离株对小鼠进行攻毒试验,结果感染小鼠显示出典型的脑膜炎症状。这是首次报道从猪体内分离O. anthropi,表明O. anthropi 可能具有更广泛的宿主感染谱。

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