期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

《工程(英文)》 >> 2021年 第7卷 第10期 doi: 10.1016/j.eng.2021.02.020

早期监测肝细胞癌的新型非蛋白生物标志物

a Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
b Weill Medical College, Cornell University, New York, NY 10065, USA
c Berry Oncology Corporation, Beijing 102200, China
d Division of Liver Diseases, Division of Hematology/Medical Oncology, Liver Cancer Program, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

收稿日期: 2020-09-20 修回日期: 2020-11-16 录用日期: 2021-02-24 发布日期: 2021-07-24

下一篇 上一篇

摘要

肝细胞癌(HCC)早期检测是对处于早期阶段的肝细胞癌进行检出的方法,对降低高风险患者的HCC死亡率至关重要。然而,对于早期HCC,目前仍然缺乏具有高度灵敏性和特异性的监测生物标志物。近年来,人们对循环系统中可检测到的肿瘤源性分子特征进行了大量研究,比如循环肿瘤脱氧核糖核酸(ctDNA)和循环肿瘤核糖核酸(ctRNA),以探讨它们作为多种肿瘤类型的候选非侵入性生物标志物的潜力。本文汇总了目前有关早期HCC检测的新方法及应用的研究。

参考文献

[ 1 ] Villanueva A. Hepatocellular carcinoma. N Engl J Med 2019;380(15):1450–62. 链接1

[ 2 ] Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšic´ M, et al. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet 2018;391 (10125):1023–75. 链接1

[ 3 ] Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, et al. Hepatocellular carcinoma. Nat Rev Dis Primers 2016;2(1):16018. 链接1

[ 4 ] Cancer stat facts: liver and and intrahepatic bile duct cancer [Internet]. Washington, DC: National Cancer Institute; c2020 [cited 2020 Jul 6]. Available from: https://seer.cancer.gov/statfacts/html/livibd.html.

[ 5 ] Van Meer S, de Man RA, Coenraad MJ, Sprengers D, van Nieuwkerk KMJ, Klümpen HJ, et al. Surveillance for hepatocellular carcinoma is associated with increased survival: results from a large cohort in the Netherlands. J Hepatol 2015;63(5):1156–63. 链接1

[ 6 ] Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology 2018;68(2):723–50. 链接1

[ 7 ] European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol 2018;69 (1):182–236. 链接1

[ 8 ] Kanwal F, Singal AG. Surveillance for hepatocellular carcinoma: current best practice and future direction. Gastroenterology 2019;157(1):54–64. 链接1

[ 9 ] Singal A, Volk ML, Waljee A, Salgia R, Higgins P, Rogers MAM, et al. Metaanalysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis. Aliment Pharmacol Ther 2009;30(1):37–47. 链接1

[10] Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, et al. Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis. Gastroenterology 2018;154 (6):1706–18.e1. 链接1

[11] Choi JY, Jung SW, Kim HY, Kim M, Kim Y, Kim DG, et al. Diagnostic value of AFP-L3 and PIVKA-II in hepatocellular carcinoma according to total-AFP. World J Gastroenterol 2013;19(3):339–46. 链接1

[12] Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, et al. The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers. Cancer Epidemiol Biomarkers Prev 2014;23(1):144–53. 链接1

[13] FDA grants Breakthrough Device Designation for Roche’s Elecsys GALAD score to support earlier diagnosis of hepatocellular carcinoma [Internet]. Basel: Roche; c2021 [cited 2020 Jul 30]. Available from: https://www. roche.com/media/releases/med-cor-2020-03-04.htm.

[14] Wen L, Li J, Guo H, Liu X, Zheng S, Zhang D, et al. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Res 2015;25(11):1250–64. 链接1

[15] Xu RH, Wei W, Krawczyk M, Wang W, Luo H, Flagg K, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater 2017;16(11):1155–61. 链接1

[16] Kisiel JB, Dukek BA, VSR Kanipakam R, Ghoz HM, Yab TC, Berger CK, et al. Hepatocellular carcinoma detection by plasma methylated DNA: discovery, phase I pilot, and phase II clinical validation. Hepatology 2019;69(3):1180–92. 链接1

[17] Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, et al. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. Gut 2019;68 (12):2195–205. 链接1

[18] Tao K, Bian Z, Zhang Q, Guo X, Yin C, Wang Y, et al. Machine learning-based genome-wide interrogation of somatic copy number aberrations in circulating tumor DNA for early detection of hepatocellular carcinoma. EBioMedicine 2020;56:102811. 链接1

[19] Jiang P, Sun K, Tong YK, Cheng SH, Cheng THT, Heung MMS, et al. Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma. Proc Natl Acad Sci USA 2018;115 (46):E10925–33. 链接1

[20] Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z, et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol 2011;29(36):4781–8. 链接1

[21] Tan Y, Ge G, Pan T, Wen D, Chen L, Yu X, et al. A serum microRNA panel as potential biomarkers for hepatocellular carcinoma related with hepatitis B virus. PLoS ONE 2014;9(9):e107986. 链接1

[22] Lin XJ, Chong Y, Guo ZW, Xie C, Yang XJ, Zhang Q, et al. A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested casecontrol study. Lancet Oncol 2015;16(7):804–15. 链接1

[23] Yuan W, Sun Y, Liu L, Zhou B, Wang S, Gu D. Circulating lncRNAs serve as diagnostic markers for hepatocellular carcinoma. Cell Physiol Biochem 2017;44(1):125–32. 链接1

[24] Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, et al. A viral exposure signature defines early onset of hepatocellular carcinoma. Cell 2020;182(2):317–28.e10. 链接1

[25] Qu C, Wang Y, Wang P, Chen K, Wang M, Zeng H, et al. Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy. Proc Natl Acad Sci USA 2019;116(13):6308–12. 链接1

[26] Chen L, Abou-Alfa GK, Zheng B, Liu JF, Bai J, Du LT, et al. Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients. Cell Res 2021;31(5):589–92. 链接1

[27] Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, et al. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature 2017;545(7655):446–51. 链接1

[28] Von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A. Liquid biopsy in the clinical management of hepatocellular carcinoma. Gut 2020;69 (11):2025–34. 链接1

[29] Labgaa I, Villacorta-Martin C, D’Avola D, Craig AJ, von Felden J, Martins-Filho SN, et al. A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. Oncogene 2018;37 (27):3740–52. 链接1

[30] Villanueva A, Portela A, Sayols S, Battiston C, Hoshida Y, Méndez-González J, et al. DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma. Hepatology 2015;61(6):1945–56. 链接1

[31] Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV, Liu MC, et al. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA. Ann Oncol 2020;31(6):745–59. 链接1

[32] Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009;324(5929):930–5. 链接1

[33] Song CX, Yin S, Ma L, Wheeler A, Chen Y, Zhang Y, et al. 5- hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res 2017;27(10):1231–42. 链接1

[34] Li W, Zhang X, Lu X, You L, Song Y, Luo Z, et al. 5-hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers. Cell Res 2017;27(10):1243–57. 链接1

[35] Xu H, Zhu X, Xu Z, Hu Y, Bo S, Xing T, et al. Non-invasive analysis of genomic copy number variation in patients with hepatocellular carcinoma by next generation DNA sequencing. J Cancer 2015;6(3):247–53. 链接1

[36] Ivanov M, Baranova A, Butler T, Spellman P, Mileyko V. Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation. BMC Genomics 2015;16(Suppl 13):S1. 链接1

[37] Jiang P, Chan CWM, Chan KCA, Cheng SH, Wong J, Wong VS, et al. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc Natl Acad Sci USA 2015;112(11):E1317–25. 链接1

[38] Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature 2019;570 (7761):385–9. 链接1

[39] Jiang P, Sun K, Peng W, Cheng SH, Ni M, Yeung PC, et al. Plasma DNA end-motif profiling as a fragmentomic marker in cancer, pregnancy, and transplantation. Cancer Discov 2020;10(5):664–73. 链接1

[40] Snyder MW, Kircher M, Hill AJ, Daza RM, Shendure J. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin. Cell 2016;164(1–2):57–68. 链接1

[41] Ulz P, Thallinger GG, Auer M, Graf R, Kashofer K, Jahn SW, et al. Inferring expressed genes by whole-genome sequencing of plasma DNA. Nat Genet 2016;48(10):1273–8. 链接1

[42] Cohen JD, Li L, Wang Y, Thoburn C, Afsari B, Danilova L, et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018;359(6378):926–30. 链接1

[43] Lennon AM, Buchanan AH, Kinde I, Warren A, Honushefsky A, Cohain AT, et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science 2020;369(6499):eabb9601. 链接1

[44] Pepe MS, Etzioni R, Feng Z, Potter JD, Thompson ML, Thornquist M, et al. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst 2001;93(14):1054–61. 链接1

相关研究