[ 1 ] Forrester MB, Merz RD. Risk of selected birth defects with prenatal illicit drug use, Hawaii, 1986‒2002. J Toxicol Environ Health A 2007;70(1):7‒18. 链接1

[ 2 ] Reece AS, Hulse GK. Cannabis teratology explains current patterns of Coloradan congenital defects: the contribution of increased cannabinoid exposure to rising teratological trends. Clin Pediatr 2019;58(10):1085‒123. 链接1

[ 3 ] Reece AS, Hulse GK. Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis. BMC Pharmacol Toxicol 2020;21(1):75‒103. 链接1

[ 4 ] Reece AS, Hulse GK. Canadian cannabis consumption and patterns of congenital anomalies: an ecological geospatial analysis. J Addict Med 2020;14(5):e195‒210. 链接1

[ 5 ] Reece AS, Hulse GK. Cannabinoid and substance relationships of European congenital anomaly patterns: a space‒time panel regression and causal inferential study. Environ Epigenet 2022;8(1):b015. 链接1

[ 6 ] Reece AS, Hulse GK. Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in relation to congenital anomalies 2001‒2015. BMC Pediatr 2022;22(1):47‒124. 链接1

[ 7 ] Reece AS, Hulse GK. Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003‒2017: part 1—continuous bivariate analysis. Arch Public Health 2022;80(1):99‒133. 链接1

[ 8 ] VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med 2017;167(4):268‒74. 链接1

[ 9 ] Pearl J, Mackaenzie D. The new science of cause and effect. The book of why. New York City: Basic Books; 2019.

[10] Phillips KT, Pedula KL, Choi NG, Tawara KK, Simiola V, Satre DD, et al. Chronic health conditions, acute health events, and healthcare utilization among adults over age 50 in Hawai’i who use cannabis: a matched cohort study. Drug Alcohol Depend 2022;234:109387. 链接1

[11] Allen JP, Danoff JS, Costello MA, Hunt GL, Hellwig AF, Krol KM, et al. Lifetime marijuana use and epigenetic age acceleration: a 17-year prospective examination. Drug Alcohol Depend 2022;233:109363. 链接1

[12] Reece AS, Norman A, Hulse GK. Cannabis exposure as an interactive cardiovascular risk factor and accelerant of organismal ageing: a longitudinal study. BMJ Open 2016;6(11):e011891‒901. 链接1

[13] Pucci M, Rapino C, Di Francesco A, Dainese E, D’Addario C, Maccarrone M. Epigenetic control of skin differentiation genes by phytocannabinoids. Br J Pharmacol 2013;170(3):581‒91. 链接1

[14] Chien KR, Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell 2005;120(4):533‒44. 链接1

[15] Manthey J, Freeman TP, Kilian C, Lopez-Pelayo H, Rehm J. Public health monitoring of cannabis use in Europe: prevalence of use, cannabis potency, and treatment rates. Lancet Reg Health Eur 2021;10:100227‒200237. 链接1

[16] United Nations Office on Drugs and Crime. World drug report 2021 [Internet]. United Nations Office on Drugs and Crime; 2021 [cited 2022 Jan 10]. Available from: https://wdr.unodc.org/wdr2019/index.html. 链接1

[17] Nahas GG. Cannabis physiopathology epidemiology detection. Boca Raton, FL: CRC Press Revivals; 1990.

[18] Nahas GG. Keep off the grass. Middlebury: Elsevier; 1990.

[19] Reece AS, Hulse GK. Congenital anomaly epidemiological correlates of D8THC across USA 2003‒2016: panel regression and causal inferential study. Environ Epigenet 2022;8(1):dvac012. 链接1

[20] Reece AS, Hulse GK. Epidemiology of D8THC-related carcinogenesis in USA: a panel regression and causal inferential study. Int J Environ Res Public Health 2022;19(13):7726. 链接1

[21] Russo C, Ferk F, Mišík M, Ropek N, Nersesyan A, Mejri D, et al. Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells. Arch Toxicol 2019;93(1):179‒88. 链接1

[22] Reece AS, Hulse GK. Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development. Sci Rep 2021;11(1):13892‒912. 链接1

[23] Reece AS, Hulse GK. Epidemiological association of cannabinoid- and drugexposures and sociodemographic factors with limb reduction defects across USA 1989‒2016: a geotemporospatial study. Spat Spatio‒Temporal Epidemiol 2022;41:100480‒90. 链接1

[24] Reece AS. Limblessness: cannabinoids inhibit key embryonic morphogens both directly and epigenomically. BMJ. .

[25] Nahas GG, Morishima A, Desoize B. Effects of cannabinoids on macromolecular synthesis and replication of cultured lymphocytes. Fed Proc 1977;36(5):1748‒52.

[26] Huang HFS, Nahas GG, Hembree WC. Effects of marijuana inhalation on spermatogenesis of the rat. In: Marijuana in medicine. New York City: Human Press; 1999. p. 359‒66. 链接1

[27] Morishima A. Effects of cannabis and natural cannabinoids on chromosomes and ova. NIDA Res Monogr 1984;44:25‒45.

[28] Harkany T, Horvath TL. (S)Pot on mitochondria: cannabinoids disrupt cellular respiration to limit neuronal activity. Cell Metab 2017;25(1):8‒10. 链接1

[29] Cantó C, Menzies KJ, Auwerx J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab 2015;22(1):31‒53. 链接1

[30] Schrott R, Murphy SK, Modliszewski JL, King DE, Hill B, Itchon-Ramos N, et al. Refraining from use diminishes cannabis-associated epigenetic changes in human sperm. Environ Epigenet 2021;7(1):b009. 链接1

[31] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126(4):663‒76. 链接1

[32] Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318(5858):1917‒20. 链接1

[33] Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 2016;167(7):1719‒33.e12. 链接1

[34] Alpár A, Tortoriello G, Calvigioni D, Niphakis MJ, Milenkovic I, Bakker J, et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun 2014;5(1):4421. 链接1

[35] Smith AM, Mioduszewski O, Hatchard T, Byron-Alhassan A, Fall C, Fried PA. Prenatal marijuana exposure impacts executive functioning into young adulthood: an fMRI study. Neurotoxicol Teratol 2016;58:53‒9. 链接1

[36] Brents L. Correlates and consequences of prenatal cannabis exposure (PCE): identifying and characterizing vulnerable maternal populations and determining outcomes in exposed offspring. In: Preedy VR, editor. Handbook of cannabis and related pathologies: biology, pharmacology, diagnosis and treatment. London: Academic Press; 2017. p.160‒70. 链接1

[37] Reece AS, Hulse GK. Co-occurrence across time and space of drug- and cannabinoid-exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis. BMC Public Health 2020;20(1):1655‒69. 链接1

[38] Reece AS, Hulse GK. Impact of converging sociocultural and substancerelated trends on US autism rates: combined geospatiotemporal and causal inferential analysis. Eur Arch Psychiatry Clin Neurosci 2022;19(13):7726‒52. 链接1

[39] Reece AS, Hulse GK. Epidemiological associations of various substances and multiple cannabinoids with Autism in USA. Clinical Pediatrics: Open Access 2019;4(2):1‒20.

[40] Reece AS, Hulse GK. Effect of cannabis legalization on US Autism incidence and medium term projections. Clinical Pediatrics: Open Access 2019;4(2):1‒17.

[41] Editorial by South China Morning Post. A lack of research into CBD means its best to err on the side of caution [Internet]. Hong Kong: South China Morning Post; 2022 [cited 2022 Jun 14]. Available from: https://www.scmp.com/comment/opinion/hong-kong/article/3181359/lack-research-cbd-meansits-best-err-side-caution. 链接1

[42] Fish EW, Murdaugh LB, Zhang C, Boschen KE, Boa-Amponsem O, MendozaRomero HN, et al. Cannabinoids exacerbate alcohol teratogenesis by a CB1-Hedgehog interaction. Sci Rep 2019;9(1):16057‒75. 链接1

[43] Meacham MC, Bahorik AL, Shumway M, Marquez C, Riley ED. Condomless sex and psychiatric comorbidity in the context of constrained survival choices: a longitudinal study among homeless and unstably housed women. AIDS Behav 2019;23(3):802‒12. 链接1

[44] Meacham MC, Ramo DE, Kral AH, Riley ED. Associations between medical cannabis and other drug use among unstably housed women. Int J Drug Policy 2018;52:45‒51. 链接1

[45] Patanwala M, Tieu L, Ponath C, Guzman D, Ritchie CS, PhysicalKushel M., psychological, social, and existential symptoms in older homeless-experienced adults: an observational study of the hope home cohort. J Gen Intern Med 2018;33(5):635‒43. 链接1

[46] Riley ED, Vittinghoff E, Wu AHB, Coffin PO, Hsue PY, Kazi DS, et al. Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women. Drug Alcohol Depend 2020;217:108252. 链接1