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虚实融合的协同工作环境CAR-CA工程技术研究进展

赵沁平

《中国工程科学》 2009年第11卷第10期页码 25-31

摘要：

采用虚实融合和协同工作技术进行大型装备的设计论证和辅助拆装维护是工程科技发展的一个新方向。面向我国自行设计生产商用大飞机的需求，在863计划支持下，正在研制用于驾驶舱布局设计和飞机关键部件辅助拆装维护的虚实融合协同工作环境CAR-CA（collaborative augmented reality概要介绍CAR-CA的工程技术研究进展，包括体系结构、系统组成、关键技术研究和系统的应用前景等。

关键词：虚实融合协同工作驾驶舱设计维护

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智能自主寻迹小车测控系统的研究与设计

王玲,张强,李雪梅

《中国工程科学》 2014年第16卷第3期页码 92-98

摘要：

智能小车的测控系统是小车设计中的关键技术之一，灵敏完备的测控系统可以有效提高智能小车运行的稳定性，介绍了智能自主寻迹小车测控系统的整体架构和软硬件设计过程。

关键词：智能小车测控系统模糊PID控制双P控制算法

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嵌合抗原受体和调节性T细胞——移植中人类白细胞抗原特异性免疫抑制的潜力 Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

《工程（英文）》 2022年第10卷第3期页码 30-43 doi: 10.1016/j.eng.2021.10.018

摘要：

嵌合抗原受体（CAR）是基因工程领域的一项突破，它彻底改变了过继细胞疗法（ACT）领域。表达这些受体的细胞通过在合成的CAR构建体中包含抗原特异性结合区域而被重新定向到预定的靶点。Treg 中CAR的表达被认为是治疗自身免疫和炎症性疾病、移植物抗宿主病（GVHD）和器官移植排斥反应的一种方法。在后者中，它们作为同种异体移植受者免疫耐受的介质具有巨大的潜力。然而，目前对CAR-Treg 工程的研究非常有限，并且关于治疗用途的最佳设计存在不确定性。本文综述了CAR-Treg 发展的理论基础、其对人类移植的意义、潜在的设计、安全性考虑因素，以及迄今为止CAR-Treg在移植模型中的对比。

关键词：嵌合抗原受体（CAR）调节性T细胞异性免疫 CAR设计基因编辑

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中国私用轿车发展的现状与问题

郭孔辉

《中国工程科学》 2000年第2卷第8期页码 25-30

摘要：

目前国内对中国应不应该发展私用轿车，中国应着重发展什么样的轿车，中国应不应该发展自己的轿车工业，中国轿车工业的出路在哪里，以及应如何发展中国的轿车工业，……等等，讨论颇多，已经成为社会上普遍关心的问题。文章试图分析目前提出的有代表性的各种观点，并对有关问题提出笔者自己的见解，以供参考。笔者认为解决"汽车灾难"问题的根本出路不在抑制私用轿车的发展，而在于发展汽车高新技术，加强城市规划与交通管理。文章在肯定引进合资对提高我国汽车制造技术和管理水平的重要作用的同时，指出它的负面影响是逐渐丧失产品开发的主动权；提出中国汽车工业的总战略应是："自强不息加国际合作"，其中包括：高新技术战略、自主双赢战略、内联自强战略、自主品牌战略和跨越赶超战略。

关键词：中国汽车工业私用轿车家用轿车现状与问题

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

null

《医学前沿（英文）》 2017年第11卷第4期页码 554-562 doi: 10.1007/s11684-017-0543-6

摘要：

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.

关键词： CAR-T CRISPR-Cas9 LAG-3

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Thermal response of steel framing members in open car park fires

Xia YAN; Marion CHARLIER; Thomas GERNAY

《结构与土木工程前沿（英文）》 2022年第16卷第9期页码 1071-1088 doi: 10.1007/s11709-022-0879-0

摘要： For open car park structures, adopting a performance-based structural fire design is often justified and allowed because the fire does not reach flashover. However, this design approach requires an accurate assessment of temperatures in structural members exposed to car fires. This paper describes a numerical study on the thermal exposure on steel framing members in open car park fires. Steel temperatures are computed by the coupling of computational fluid dynamics and finite element modeling, and by analytical models from the Eurocodes. In addition, the influence of galvanization on the steel temperature evolution is assessed. Results show that temperatures in unprotected beams and columns are influenced by the section geometry, car fire scenario, modeling approach, and use of galvanization. Galvanization slightly delays and reduces peak temperature. Regarding the different models, CFD-FEM (CFD: computational fluid dynamics, FEM: finite-element method) coupled models predict lower temperatures than the Hasemi model, because the latter conservatively assumes that the fire flame continuously touches the ceiling. Further, the Hasemi model cannot account for the effect of reduced emissivity from galvanization on the absorbed heat flux. Detailed temperature distributions obtained in the steel members can be used to complete efficient structural fire designs based on the member sections, structure layout, and use of galvanization.

关键词： open car park localized fire steel frame numerical modeling computational fluid dynamics

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电动汽车市场加速发展

Chris Palmer

《工程（英文）》 2021年第7卷第2期页码 136-138 doi: 10.1016/j.eng.2020.12.009

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

《医学前沿（英文）》 2021年第15卷第6期页码 783-804 doi: 10.1007/s11684-021-0904-z

摘要： The current standard of care in hematological malignancies has brought considerable clinical benefits to patients. However, important bottlenecks still limit optimal achievements following a current medical practice. The genetic complexity of the diseases and the heterogeneity of tumor clones cause difficulty in ensuring long-term efficacy of conventional treatments for most hematological disorders. Consequently, new treatment strategies are necessary to improve clinical outcomes. Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematological malignancies. In this review, through a representative case study, we summarize the current experience of CAR T-cell therapy, the management of common side effects, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell therapy.

关键词： CAR T cells hematological malignancies review

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A fully solid-state cold thermal energy storage device for car seats using shape-memory alloys

《能源前沿（英文）》 2023年第17卷第4期页码 504-515 doi: 10.1007/s11708-022-0855-3

摘要： Thermal energy storage has been a pivotal technology to fill the gap between energy demands and energy supplies. As a solid-solid phase change material, shape-memory alloys (SMAs) have the inherent advantages of leakage free, no encapsulation, negligible volume variation, as well as superior energy storage properties such as high thermal conductivity (compared with ice and paraffin) and volumetric energy density, making them excellent thermal energy storage materials. Considering these characteristics, the design of the shape-memory alloy based the cold thermal energy storage system for precooling car seat application is introduced in this paper based on the proposed shape-memory alloy-based cold thermal energy storage cycle. The simulation results show that the minimum temperature of the metal boss under the seat reaches 26.2 °C at 9.85 s, which is reduced by 9.8 °C, and the energy storage efficiency of the device is 66%. The influence of initial temperature, elastocaloric materials, and the shape-memory alloy geometry scheme on the performance of car seat cold thermal energy storage devices is also discussed. Since SMAs are both solid-state refrigerants and thermal energy storage materials, hopefully the proposed concept can promote the development of more promising shape-memory alloy-based cold and hot thermal energy storage devices.

关键词： shape-memory alloy (SMA) elastocaloric effect (eCE) cooled seat cold thermal energy storage

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

《医学前沿（英文）》 2020年第14卷第6期页码 726-745 doi: 10.1007/s11684-020-0746-0

摘要： Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

关键词： CAR T cells immunoregulatory molecules endogenous immune response solid malignancies

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

《医学前沿（英文）》 2022年第16卷第3期页码 322-338 doi: 10.1007/s11684-021-0901-2

摘要： Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

关键词： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

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发展共享汽车推动汽车强国建设

乔英俊,纪雪洪

《中国工程科学》 2018年第20卷第1期页码 120-126 doi: 10.15302/J-SSCAE-2018.01.017

摘要：

本文介绍了共享汽车在国内外的发展现状与前景，并结合现阶段汽车发展的低碳化、电动化、网联化、智能化和共享化等新特征，着重对共享化推动汽车转型发展的影响进行了阐述。在此基础上，提出政府应将共享汽车放在汽车强国建设的战略高度，创造良好的发展环境，推动共享汽车在我国快速发展。

关键词：共享汽车汽车强国问题政策

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exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR

《医学前沿（英文）》 doi: 10.1007/s11684-023-1010-1

摘要： Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling

关键词： exosomes induce activation impair function CD19 exosomal CD19 antigen

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GPS民间应用的一个最大市场——汽车导航系统

赵会平

《中国工程科学》 2001年第3卷第8期页码 64-69

摘要：

汽车导航系统是解决城市交通拥堵的一种高科技手段，是21世纪智能交通（ITS）的发展方向。我们应跳出“要致富先修路”的单纯想法，用科学的方法减少占用可耕地，促进汽车工业的发展。文章着重介绍了汽车导航系统的结构与工作原理，提出了三重精度的工程方案，其市场前景广阔。

关键词： GPS 汽车导航系统 ITS

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Stability analysis of slopes with planar failure using variational calculus and numerical methods

Norly BELANDRIA, Roberto ÚCAR, Francisco M. LEÓN, Ferri HASSANI

《结构与土木工程前沿（英文）》 2020年第14卷第5期页码 1262-1273 doi: 10.1007/s11709-020-0657-9

摘要： This study investigates the technique of variational calculus applied to estimate the slope stability considering the mechanism of planar failure. The critical plane failure surface should be determined because it theoretically indicates the most unfavorable plane to be considered when stabilizing a slope to rectify the instability generated by several statistically possible planes. This generates integrals that can be solved by numerical methods, such as the Newton Cotes and the finite differences methods. Additionally, a system of nonlinear equations is obtained and solved. The surface of the critical planar failure is determined by applying the condition of transversality in mobile boundaries, for which various examples are provided. The number of slices is varied in one of the examples, while the surface of the critical planar failure is determined in the others. Results are compared using analytical methods through axis rotations. All the results obtained by considering normal stress, safety factors, and critical planar failure are nearly the same; however, in this research, a study is carried out for “ ” number of slices using programming methods. Sub-routines are important because they can be applied in slopes with different geometry, surcharge, interstitial pressure, and pseudo-static load.

关键词： slopes stability planar failure variational calculus numerical methods