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《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1739-4
● We tracked Chinese cities’ MSW disposal infrastructure development history.
关键词: China Municipal solid waste (MSW) Landfill Incineration Proliferation patterns Driving forces
Erhui GUO,Liding CHEN,Ranhao SUN,Zhaoming WANG
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 279-287 doi: 10.1007/s11783-014-0667-8
关键词: riparian vegetation patterns soil nutrient distribution nutrient loss management
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and
《医学前沿(英文)》 2023年 第17卷 第1期 页码 132-142 doi: 10.1007/s11684-022-0938-x
Microenvironmental time-activity patterns in Chongqing, China
Yu ZHAO, Shuxiao WANG, Gangcai CHEN, Fei WANG, Kristin AUNAN, Jiming HAO
《环境科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 200-209 doi: 10.1007/s11783-009-0010-y
关键词: time-activity patterns microenvironment general linear model (GLM) Chongqing China
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 41-51 doi: 10.1007/s11684-016-0429-z
Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.
关键词: breast cancer MID2 proliferation overall survival xenograft
Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence
《医学前沿(英文)》 doi: 10.1007/s11684-023-1019-5
关键词: sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern
The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
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《医学前沿(英文)》 2018年 第12卷 第4期 页码 412-425 doi: 10.1007/s11684-018-0650-z
Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-family of related basic-helix-loop-helix-zipper (bHLHZ) proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.
Meng SONG, Wei SUN
《能源前沿(英文)》 2022年 第16卷 第1期 页码 64-73 doi: 10.1007/s11708-021-0732-5
关键词: thermostatically controlled load demand response renewable energy power system operation
《医学前沿(英文)》 2021年 第15卷 第6期 页码 942-942 doi: 10.1007/s11684-021-0876-z
Xin TIAN, Hidefumi IMURA, Miao CHANG, Feng SHI, Hiroki TANIKAWA
《环境科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 445-458 doi: 10.1007/s11783-011-0330-6
关键词: carbon dioxide emission patterns China economic development index decomposition analysis industrialization
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 72-80 doi: 10.15302/J-FASE-2016089
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 289-300 doi: 10.1007/s11684-017-0550-7
Silver-containing preparations are widely used in the management of skin wounds, but the effects of silver ions on skin wound healing remain poorly understood. This study investigated the effects of silver ions (Ag+) on the proliferation of human skin keratinocytes (HaCaT) and the production of intracellular reactive oxygen species (ROS). After treating HaCaT cells with Ag+and/or the active oxygen scavenger N-acetyl cysteine (NAC), cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DA fluorescent probe, respectively. In addition, 5-bromo-2-deoxyUridine (BrdU) incorporation assays, cell cycle flow cytometry, and proliferating cell nuclear antigen (PCNA) immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic Ag+ concentrations on HaCaT cells. The proliferation of HaCaT cells was promoted in the presence of 10−6 and 10−5 mol/L Ag+ at 24, 48, and 72 h. Intracellular ROS generation also significantly increased for 5–60 min after exposure to Ag+. The number of BrdU-positive cells and the presence of PCNA in HaCaT cells increased 48 h after the addition of 10−6 and 10−5 mol/L Ag+, with 10−5 mol/L Ag+ markedly increasing the cell proliferation index. These effects of sub-cytotoxic Ag+ concentrations were repressed by 5 mmol/L NAC. Our results suggest that sub-cytotoxic Ag+ concentrations promote the proliferation of human keratinocytes and might be associated with a moderate increase in intracellular ROS levels. This study provides important experimental evidence for developing novel silver-based wound agents or dressings with few or no cytotoxicity.
关键词: ionic silver human keratinocyte cell proliferation reactive oxygen species active oxygen scavenger NAC
Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture
《医学前沿(英文)》 doi: 10.1007/s11684-023-1023-9
关键词: famine obesity body mass index waist-to-hip ratio low-energy fracture
Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface
Linlin LIANG, Bei XU, Guijin ZHU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 220-226 doi: 10.1007/s11684-009-0037-2
关键词: gonadotropin-releasing hormone ovarian reserve embryo developmental ability ovarian surface epithelium
ZHAN Rong, YU Qinghong, HUANG Haobo
《医学前沿(英文)》 2008年 第2卷 第4期 页码 356-360 doi: 10.1007/s11684-008-0068-0
关键词: VEGF expression expression variation culture supernatant labeling concentration
标题 作者 时间 类型 操作
Exploring the development of municipal solid waste disposal facilities in Chinese cities: patterns and
期刊论文
Effects of riparian vegetation patterns on the distribution and potential loss of soil nutrients: a case
Erhui GUO,Liding CHEN,Ranhao SUN,Zhaoming WANG
期刊论文
Microenvironmental time-activity patterns in Chongqing, China
Yu ZHAO, Shuxiao WANG, Gangcai CHEN, Fei WANG, Kristin AUNAN, Jiming HAO
期刊论文
is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation
null
期刊论文
Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence
期刊论文
Applications of thermostatically controlled loads for demand response with the proliferation of variable
Meng SONG, Wei SUN
期刊论文
is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation
期刊论文
Analysis of driving forces behind diversified carbon dioxide emission patterns in regions of the mainland
Xin TIAN, Hidefumi IMURA, Miao CHANG, Feng SHI, Hiroki TANIKAWA
期刊论文
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
期刊论文
Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing
null
期刊论文
Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface
Linlin LIANG, Bei XU, Guijin ZHU
期刊论文