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ZHANG Fumin, GUO Maiping, GE Hanqing, WANG Jun
《化学科学与工程前沿(英文)》 2007年 第1卷 第3期 页码 296-299 doi: 10.1007/s11705-007-0054-0
关键词: conversion heteropoly Characterization efficient catalyst Keggin-type phosphomolybdic
《机械工程前沿(英文)》 2021年 第16卷 第4期 页码 765-781 doi: 10.1007/s11465-021-0655-1
关键词: generalized parallel mechanism configurable moving platform gripper mechanism type synthesis kinematic analysis
张美麟,张晔,杨治义
《中国工程科学》 2002年 第4卷 第6期 页码 5-8
提出了一种关于自由度平面闭链机构的构型方法,即“平面图形构造方法”。利用这种方法进行机构结构综合的主要过程是:先根据机械功能确定运动链的组成成分;再按这些成分构造平面图;最后在平面图上进行机构的构型和变异,并将其中结构最优者转换为机构简图。
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿(英文)》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
Personalized medicine of type 2 diabetes
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Automated synthesis of steady-state continuous processes using reinforcement learning
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 288-302 doi: 10.1007/s11705-021-2055-9
关键词: automated process synthesis flowsheet synthesis artificial intelligence machine learning reinforcement learning
Metabolomics in human type 2 diabetes research
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词: metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 1071-1071 doi: 10.1007/s11709-021-0736-6
The mechanisms linking adiposopathy to type 2 diabetes
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 433-444 doi: 10.1007/s11684-013-0288-9
Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.
Mechanical performance analysis and stiffness test of a new type of suspension bridge
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1160-1180 doi: 10.1007/s11709-021-0760-6
关键词: new type of suspension bridge stiffness test mechanical performance railway bridge space truss
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
《医学前沿(英文)》 2019年 第13卷 第4期 页码 427-437 doi: 10.1007/s11684-018-0672-6
关键词: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
《能源前沿(英文)》 2009年 第3卷 第4期 页码 414-422 doi: 10.1007/s11708-009-0038-5
关键词: axial-type fan gradient method free-vortex method design variable total pressure static pressure operating flowrate
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 497-504 doi: 10.1007/s11783-011-0256-z
关键词: 13X-type zeolite CO oxidation gold solution pH calcination temperature
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 195-199 doi: 10.1007/s11684-008-0037-7
关键词: chemotactic activity receptor uPA inhibitor F10 chemoattractant
标题 作者 时间 类型 操作
A new method for the synthesis of molybdovanadophosphoric heteropoly acids and their catalytic activities
ZHANG Fumin, GUO Maiping, GE Hanqing, WANG Jun
期刊论文
Design and analysis of the gripper mechanism based on generalized parallel mechanisms with configurable moving platform
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and
期刊论文
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
期刊论文
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
期刊论文
Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
期刊论文