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Targeting “undruggable” c-Myc protein by synthetic lethality
Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu
《医学前沿(英文)》 2021年 第15卷 第4期 页码 541-550 doi: 10.1007/s11684-020-0780-y
关键词: synthetic lethality undruggable transcription factor c-Myc
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
《医学前沿(英文)》 2022年 第16卷 第3期 页码 442-458 doi: 10.1007/s11684-021-0877-y
关键词: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 412-425 doi: 10.1007/s11684-018-0650-z
Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-family of related basic-helix-loop-helix-zipper (bHLHZ) proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.
FU Juan, JIANG Yiguo, CHEN Xuemin
《医学前沿(英文)》 2008年 第2卷 第4期 页码 380-385 doi: 10.1007/s11684-008-0073-3
关键词: transcriptase-polymerase vehicle-treated understood molecular mechanism different
标题 作者 时间 类型 操作
Targeting “undruggable” c-Myc protein by synthetic lethality
Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu
期刊论文