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Genetic study and molecular breeding for high phosphorus use efficiency in maize
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《农业科学与工程前沿(英文)》 2019年 第6卷 第4期 页码 366-379 doi: 10.15302/J-FASE-2019278
Phosphorus is the second most important macronutrient after nitrogen and it has many vital functions in the life of plants. Most soils have a low available P content, which has become a key limiting factor for increasing crop production. Also, low P use efficiency (PUE) of crops in conjunction with excessive application of P fertilizers has resulted in serious environmental problems. Thus, dissecting the genetic architecture of crop PUE, mining related quantitative trait loci (QTL) and using molecular breeding methods to improve high PUE germplasm are of great significance and serve as an efficient approach for the development of sustainable agriculture. In this review, molecular and phenotypic characteristics of maize inbred lines with high PUE, related QTL and genes as well as low-P responses are summarized. Based on this, a breeding strategy applying genomic selection as the core, and integrating the existing genetic information and molecular breeding techniques is proposed for breeding high PUE maize inbred lines and hybrids.
关键词: maize phosphorus use efficiency quantitative trait loci genetic study molecular breeding genomic selection
The genetics of Beh?et’s disease in a Chinese population
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 354-359 doi: 10.1007/s11684-012-0234-2
Beh?et’s disease is defined as a multisystemic inflammatory disease. Although the precise pathogenesis and etiology is still a mystery, accumulating evidence shows that genetic variants of immune-related genes have a profound influence on the development of Beh?et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population. A large number of gene polymorphisms were studied including STAT4, IL23R, CD40, CCR1/CCR3, STAT3, OPN, IL17, JAK2, MCP-1, CTLA4, PD-1, PD-L1, PD-L2, TGRBR3, CCR6, PTPN22, FCRL3, IRF5, SUMO4 and UBAC2. Significant associations were found between Beh?et’s disease and STAT4, IL23R, CD40, CCR1/CCR3, STAT3, MCP-1, TGFBR3, FCRL3, SUMO4, UBAC2. These genetic predisposition studies support an important role for both lymphocyte differentiation as well as ubiquitination pathways. These findings are helpful in elucidating the pathogenesis of Beh?et’s disease and hopefully will allow the development of novel treatment regimes.
夏家辉
《中国工程科学》 2000年 第2卷 第11期 页码 1-11
介绍了中国医学遗传学国家重点实验室在遗传病家系收集、疾病基因定位、疾病基因克隆和疾病基因功能研究方面的研究工作。用细胞遗传学G显带技术于1975年发现了一条与鼻咽癌相关的标记染色体t(1;3)(q44;p11);1981年将睾丸决定基因(TDF)定位于Yp11.32带;1991年以来收集遗传病家系345种共590个;1996年用显微切割、PCR、微克隆技术克隆了EXT2基因;1998年用基因家族-候选疾病基因克隆方法克隆了遗传性神经性耳聋基因GJB3;1999年用连锁分析和全基因组扫描将一种遗传性弥漫性浅表性光敏性汗孔角化症定位于12q23.2带,并在基因功能研究中发现了一个新的细胞内转运蛋白。
关键词: 遗传病家系 基因定位和克隆 基因家族-候选疾病基因克隆 基因组扫描 基因功能研究
Genetic variability of Appaloosa horses: a study of a closed breeding population from Argentina
Claudia Malena CORBI-BOTTO,Sebastian Andres SADABA,Elina Ines FRANCISCO,Paula Belen KALEMKERIAN,Juan Pedro LIRON,Egle Etel VILLEGAS-CASTAGNASSO,Guillermo GIOVAMBATTISTA,Pilar PERAL-GARCIA,Silvina DIAZ
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 175-178 doi: 10.15302/J-FASE-2014019
关键词: horse genetic diversity microsatellite Appaloosa population structure conservation
施式亮,伍爱友
《中国工程科学》 2009年 第11卷 第9期 页码 91-96
煤与瓦斯突出是煤矿地下开采过程中的一种动力现象,剧烈的动力效应可导致矿井重大的财产损失和人员伤亡,因此,实现煤与瓦斯突出的有效预测对煤炭工业安全生产具有重要意义。文章以煤与瓦斯突出的自然条件及地质构造特征为基础,针对神经网络易陷入局部极小而引起预测指标权值分布不合理的缺陷,提出了基于神经网络和遗传算法耦合的煤与瓦斯突出区域预测模型,并进行了实例验证。研究结果证明了该模型的合理性,对煤矿实现煤与瓦斯突出区域的预测具有较大的指导价值。
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
《医学前沿(英文)》 2023年 第17卷 第4期 页码 768-780 doi: 10.1007/s11684-023-0982-1
关键词: machine learning methods hypertrophic cardiomyopathy genetic risk
刘林峰,庄艳艳,刘业
《中国工程科学》 2008年 第10卷 第2期 页码 66-71
无线传感器网络的首要设计目标是延长网络生命期,网络的拓扑控制是实现这一目标的支撑基础。针对传统拓扑控制方案所获拓扑的连通冗余度高或结构健壮性低等弊端,将问题转化 为多判据最小生成树模型,提出了一种基于遗传算法的拓扑控制方案。仿真实验结果表明,该方案可获得具有网络整体功耗低、结构健壮性高和节点间通信干扰小等特点的拓扑结构,因而能够有效地延长传感器网络生命期。
关键词: 无线传感器网络 拓扑控制 多判据最小生成树问题 遗传算法
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
《医学前沿(英文)》 2018年 第12卷 第6期 页码 601-607 doi: 10.1007/s11684-018-0648-6
The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
《结构与土木工程前沿(英文)》 2019年 第13卷 第4期 页码 863-889 doi: 10.1007/s11709-019-0523-9
关键词: design optimization genetic algorithm multiple populations neural network
Research progress on genetic improvement of
Chuanping YANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 391-401 doi: 10.15302/J-FASE-2017183
关键词: Betula platyphylla genetic improvement molecular breeding seed orchard
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
《工程管理前沿(英文)》 2016年 第3卷 第1期 页码 30-38 doi: 10.15302/J-FEM-2016008
关键词: accident proneness genome-wide association study (GWAS) dopamine (DA) ACTH susceptibility gene traffic accident epidemiology accident prevention traffic safety three-dimensional model
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 305-318 doi: 10.15302/J-FASE-2017154
Search-and-replace editing of genetic information
Yao LIU, Xingxu HUANG, Xiaolong WANG
《农业科学与工程前沿(英文)》 2020年 第7卷 第2期 页码 231-232 doi: 10.15302/J-FASE-2020322
Age-related trends in genetic parameters for wood properties in
Chao SUN, Meng LAI, Shougong ZHANG, Xiaomei SUN
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 482-492 doi: 10.15302/J-FASE-2017184
关键词: early selection genetic variation wood properties SilviScan Larix kaempferi
Optimal design of steel portal frames based on genetic algorithms
CHEN Yue, HU Kai
《结构与土木工程前沿(英文)》 2008年 第2卷 第4期 页码 318-322 doi: 10.1007/s11709-008-0055-1
关键词: satisfactory genetic-algorithm-based Technical Specification algorithm efficiency
标题 作者 时间 类型 操作
Genetic variability of Appaloosa horses: a study of a closed breeding population from Argentina
Claudia Malena CORBI-BOTTO,Sebastian Andres SADABA,Elina Ines FRANCISCO,Paula Belen KALEMKERIAN,Juan Pedro LIRON,Egle Etel VILLEGAS-CASTAGNASSO,Guillermo GIOVAMBATTISTA,Pilar PERAL-GARCIA,Silvina DIAZ
期刊论文
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
期刊论文
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
期刊论文
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
期刊论文
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
期刊论文
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
期刊论文
Age-related trends in genetic parameters for wood properties in
Chao SUN, Meng LAI, Shougong ZHANG, Xiaomei SUN
期刊论文