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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 368-373 doi: 10.1007/s11684-015-0403-1
Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 μg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P<0.001), whereas GLP-2 pretreatment significantly decreased their levels (P<0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
关键词: ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1566-z
● An urchin-like OMS/ZIS composite was fabricated by a facile solvothermal method.
关键词: Dual-functional photocatalysts Oxygen-doped MoS2/ZnIn2S4 H2 evolution Organic pollutant
Orlistat induces ferroptosis-like cell death of lung cancer cells
《医学前沿(英文)》 2021年 第15卷 第6期 页码 922-932 doi: 10.1007/s11684-020-0804-7
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
《医学前沿(英文)》 2023年 第17卷 第2期 页码 263-274 doi: 10.1007/s11684-022-0935-0
关键词: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 99-102 doi: 10.1007/s11705-016-1554-6
关键词: cysteine peptide fibrils gold nanoparticles amyloids oligomers nanomaterials
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿(英文)》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词: soluble C-type lectin-like receptor-2 coronary artery disease risk factor
《化学科学与工程前沿(英文)》 2021年 第15卷 第6期 页码 1537-1549 doi: 10.1007/s11705-021-2094-2
关键词: graphene-like h-BN h-BN/NiS2/NiS composites photocatalysis Cr(VI) reduction degradation of RhB
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Mercury removal from aqueous solution using petal-like MoS2
Ragini Pirarath, Palani Shivashanmugam, Asad Syed, Abdallah M. Elgorban, Sambandam Anandan, Muthupandian Ashokkumar
《环境科学与工程前沿(英文)》 2021年 第15卷 第1期 doi: 10.1007/s11783-020-1307-0
关键词: Anionic surfactant 2D material MoS2 nanosheets Mercury removal Adsorption capacity
《化学科学与工程前沿(英文)》 2022年 第16卷 第4期 页码 498-510 doi: 10.1007/s11705-021-2082-6
关键词: electrochemical reduction of CO2 syngas N-doped carbon nanotubes encapsulated alloy nanoparticles CO/H2 ratio
Jie HOU,Rui LI,Hongfang MA,Songlin QIAO,Gaiping ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 65-71 doi: 10.15302/J-FASE-2016086
关键词: PRRSV porcine sialoadhesin V-set Ig-like domain Drosophila S2 cell crystallization
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 9-19 doi: 10.1007/s11705-013-1306-9
关键词: insulin cell penetrating peptide mucoadhesive composites oral delivery
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1520-0
• Liquid digestate humification was investigated under different oxidizing environment.
关键词: Liquid digestate MnO2 Oxygen DOM transformation Humic-like acids
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
《工程(英文)》 doi: 10.1016/j.eng.2023.01.015
关键词: Antifreeze peptides Evolution analysis Ice recrystallization inhibition Molecular dynamics simulation Cryopreservation Synthetic biology
标题 作者 时间 类型 操作
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
visible-photocatalytic hydrogen evolution and simultaneous organic pollutant degradation over an urchin-like
期刊论文
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
Graphene-like -BN supported polyhedral NiS/NiS nanocrystals with excellent photocatalytic performance
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Mercury removal from aqueous solution using petal-like MoS2
Ragini Pirarath, Palani Shivashanmugam, Asad Syed, Abdallah M. Elgorban, Sambandam Anandan, Muthupandian Ashokkumar
期刊论文
Bamboo-like -doped carbon nanotubes encapsulating M(Co, Fe)-Ni alloy for electrochemical production of
期刊论文
Structural prediction of porcine sialoadhesin V-set Ig-like domain sheds some light on its role in porcine
Jie HOU,Rui LI,Hongfang MA,Songlin QIAO,Gaiping ZHANG
期刊论文
Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
期刊论文
Effects of oxidizing environment on digestate humification and identification of substances governing the dissolved organic matter (DOM) transformation process
期刊论文