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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 239-246 doi: 10.1007/s11684-017-0509-8
Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularly high risk of nosocomial infections. We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC. The study included 465 patients who underwent SHNC between June 2011 and June 2014. The rate of VAP, risk factors for VAP, and biological aspects of VAP were retrospectively evaluated. The incidence of VAP was 19.6% (n=95) in patients who required more than 48 h of mechanical ventilation. Staphylococcus (37.7%), Enterobacteriaceae (32.1%), Pseudomonas(20.8%), and Haemophilus (16.9%) were the major bacterial species that caused VAP. The independent risk factors for VAP were advanced age, current smoking status, chronic obstructive pulmonary disease, and a higher simplified acute physiology score system II upon admission. Tracheostomy was an independent protective factor for VAP. The median length of stay in the ICU for patients who did or did not develop VAP was 8.0 and 6.5 days, respectively (P=0.006). Mortality among patients who did or did not develop VAP was 16.8% and 8.4%, respectively (P<0.001). The potential economic impact of VAP was high because of the significantly extended duration of ventilation. A predictive regression model was developed with a sensitivity of 95.3% and a specificity of 69.4%. VAP is common in patients who are undergoing SHNC and who require more than 48 h of mechanical ventilation. Therefore, innovative preventive measures should be developed and applied in this high-risk population.
关键词: ventilator-associated pneumonia (VAP) pneumonia risk factors surgery for head and neck cancer (SHNC)
《医学前沿(英文)》 2022年 第16卷 第3期 页码 389-402 doi: 10.1007/s11684-021-0856-3
关键词: severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
《医学前沿(英文)》 2021年 第15卷 第1期 页码 139-143 doi: 10.1007/s11684-019-0736-2
《医学前沿(英文)》 2022年 第16卷 第3期 页码 378-388 doi: 10.1007/s11684-021-0840-y
关键词: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
Crk-associated substrate, vascular smooth muscle and hypertension
TANG Dale
《医学前沿(英文)》 2008年 第2卷 第4期 页码 323-331 doi: 10.1007/s11684-008-0062-6
关键词: Contraction stimulation phosphatase-proline molecular structure discovered hypertension
《医学前沿(英文)》 2022年 第16卷 第3期 页码 459-466 doi: 10.1007/s11684-021-0841-x
关键词: Fanconi anemia aplastic anemia hematologic malignancy germline predisposition
《医学前沿(英文)》 2022年 第16卷 第5期 页码 714-722 doi: 10.1007/s11684-021-0888-8
关键词: metabolic dysfunction-associated fatty liver disease non-alcoholic fatty liver disease fibrosis score brachial-ankle pulse wave velocity albuminuria
Mouth the mirror of lungs: where does the connection lie?
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 405-409 doi: 10.1007/s11684-016-0476-5
Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.
关键词: periodontitis respiratory diseases acute pneumonia COPD
《环境科学与工程前沿(英文)》 2021年 第15卷 第4期 doi: 10.1007/s11783-020-1361-7
• Bacteria could easily and quickly attached onto TEP to form protobiofilms.
关键词: Transparent exopolymer particles (TEPs) TEP-protobiofilm Bacteria attachment Biofouling of membrane
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 359-364 doi: 10.1007/s11684-017-0528-5
Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.
关键词: thyroid-associated orbitopathy dysthyroid optic neuropathy orbital radiation therapy
Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
《医学前沿(英文)》 2018年 第12卷 第6期 页码 667-677 doi: 10.1007/s11684-017-0583-y
关键词: platelet-mimicking delivery systems tumor-associated platelets cancer therapy EPR effect
Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 33-42 doi: 10.1007/s11684-019-0735-3
关键词: cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review
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《医学前沿(英文)》 2016年 第10卷 第1期 页码 33-40 doi: 10.1007/s11684-016-0431-5
Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
关键词: cancer-associated fibroblast breast cancer progression prognosis
Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems
Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 284-292 doi: 10.1007/s11783-013-0555-7
关键词: particle associated polycyclic aromatic hydrocarbons (PAHs) ozone denuder sampling artifacts
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus
Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO
《医学前沿(英文)》 2009年 第3卷 第2期 页码 158-163 doi: 10.1007/s11684-009-0042-5
关键词: tetracycline regulatory system adeno-associated virus basic fibroblast growth factor gene regulation
标题 作者 时间 类型 操作
Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery
null
期刊论文
Clinical factors associated with composition of lung microbiota and important taxa predicting clinicalprognosis in patients with severe community-acquired pneumonia
期刊论文
Analysis of antibiotic usage for viral community-acquired pneumonia in adults
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
期刊论文
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein
期刊论文
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies
期刊论文
New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse
期刊论文
Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling
期刊论文
The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid
null
期刊论文
Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy
Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
期刊论文
Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
期刊论文
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
null
期刊论文
Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems
Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG
期刊论文