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Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
《医学前沿(英文)》 2020年 第14卷 第4期 页码 498-505 doi: 10.1007/s11684-020-0791-8
关键词: disorders of sex development (DSD) intelligent diagnosis dynamic uncertain causality graph
Molin HUO, Xiliang ZHANG, Jiankun HE
《能源前沿(英文)》 2011年 第5卷 第1期 页码 43-48 doi: 10.1007/s11708-010-0135-5
关键词: photovoltaic innovation demand pull scale economies granger causality
Causality between energy consumption and GDP in the U.S.: evidence from wavelet analysis
Alper ASLAN, Nicholas APERGIS, Selim YILDIRIM
《能源前沿(英文)》 2014年 第8卷 第1期 页码 1-8 doi: 10.1007/s11708-013-0290-6
关键词: energy consumption economic growth wavelet analysis granger causality
Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang
《医学前沿(英文)》 2020年 第14卷 第4期 页码 488-497 doi: 10.1007/s11684-020-0762-0
关键词: knowledge representation uncertain causality graphical model artificial intelligence diagnosis dyspnea
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 457-467 doi: 10.1007/s11684-015-0417-8
Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.
关键词: drug-induced liver injury pharmacognosy metabolomics stilbene Polygonum multiflorum Chinese herbal medicine
Relationship between electricity consumption and economic growth of Guangdong Province in China
Lianhong LV, Hong LUO, Baoliu ZHANG
《能源前沿(英文)》 2012年 第6卷 第4期 页码 351-355 doi: 10.1007/s11708-012-0209-7
关键词: co-integration granger causality electricity consumption (EC) economic growth
Electricity demand, GDP and employment: evidence from Italy
Cosimo MAGAZZINO
《能源前沿(英文)》 2014年 第8卷 第1期 页码 31-40 doi: 10.1007/s11708-014-0296-8
关键词: energy policies electricity demand GDP labor force stationarity structural breaks cointegration causality Italy
免疫球蛋白G N-糖基化与代谢特征之间的双向因果关联——一项孟德尔随机化研究 Article
孟晓妮, 曹维杰, 刘迪, Isinta Elijah Maranga, 邢薇佳, 侯海峰, 徐希柱, 宋曼殳, 王友信
《工程(英文)》 2023年 第26卷 第7期 页码 74-88 doi: 10.1016/j.eng.2022.11.004
既往研究已发现免疫球蛋白 G(immunoglobulin G, IgG)N-糖基化与代谢特征之间存在关联,但它们之间是否存在因果关联尚有待研究。本研究使用孟德尔随机化(Mendelian randomization, MR)研究方法整合全基因组关联研究(genome-wide association studies, GWAS)和数量性状基因座(quantitative trait loci, QTL)数据探究IgG N-糖基化与代谢特征之间的双向因果关联。在正向MR分析中,通过整合IgG N-糖基-QTL遗传变异与GWAS 数据和代谢特征进行分析,分别发现59个包括影响体质指数(body mass index, BMI)的9个IgG N-糖基(glycan peaks, GP)(GP1和GP6等)和影响空腹血糖(fasting plasma glucose, FPG)的 7个IgG N-糖基(GP1和GP5等)以及15个[包括影响BMI 的5个IgG N-糖基(GP2 和 GP11 等)和影响FPG的 4个IgG N-糖基(GP1和GP10等)]由遗传决定的 IgG N-糖基在单样本和两样本MR研究中与代谢特征存在因果关联(全部 P < 0.05)。相应地,对整合代谢特征-QTL-遗传变异与GWAS结果和 IgG N-糖基进行MR分析的结果显示,在单样本和两样本MR研究中,分别发现72个包括影响GP1的1个因果代谢特征[高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)]和影响GP2的5个因果代谢特征[FPG、收缩压(systolic blood pressure, SBP)等]和4个[包括影响GP3的1个因果代谢特征(HDL-C)和影响 GP9 的1个代谢特征(HDL-C)]由遗传决定的代谢特征与 IgG N-糖基之间存在因果关联(全部 P < 0.05)。值得注意的是,在单样本和两样本的MR分析中均发现了遗传决定的高水平的GP11与BMI水平增高存在因果关联[固定效应模型-Beta (SE): 0.106 (0.034) 和 0.010 (0.005)]和高水平的HDL-C与 GP9 水平降低存在因果关联[−0.071 (0.022) 和−0.306 (0.151)],且这一结果在单样本和两样本的 meta汇总分析中得到了进一步验证[固定效应模型-Beta(95%置信区间)分别为:0.0109 (0.0012, 0.0207) 和−0.0759 (−0.1186, −0.0332)]。综上所述,本研究全面的双向MR分析提供了IgG N-糖基化与代谢特征之间双向因果关联的证据,在一定程度上揭示了 IgG N-糖基化与代谢特征之间的生物学机制。
“暗”,不止于“深”——迈向认知智能与类人常识的范式转换 Feature Article
朱毅鑫, 高涛, 范丽凤, 黄思远, Mark Edmonds, 刘航欣, 高枫, 张驰, Siyuan Qi, 吴英年, Joshua B. Tenenbaum, 朱松纯
《工程(英文)》 2020年 第6卷 第3期 页码 310-345 doi: 10.1016/j.eng.2020.01.011
非线性因果效应分析中的因果域 Correspondence
王爱国1,刘礼2,杨矫云3,李廉3
《信息与电子工程前沿(英文)》 2022年 第23卷 第8期 页码 1277-1286 doi: 10.1631/FITEE.2200165
Yujia Peng,Jiaheng Han,Zhenliang Zhang,Lifeng Fan,Tengyu Liu,Siyuan Qi,Xue Feng,Yuxi Ma,Yizhou Wang,Song-Chun Zhu,
《工程(英文)》 doi: 10.1016/j.eng.2023.07.006
关键词: Artificial general intelligence Artificial intelligence benchmark Artificial intelligence evaluation Embodied artificial intelligence Value alignment Turing test Causality
标题 作者 时间 类型 操作
Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of
Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang
期刊论文
Causality relationship between the photovoltaic market and its manufacturing in China, Germany, the US
Molin HUO, Xiliang ZHANG, Jiankun HE
期刊论文
Causality between energy consumption and GDP in the U.S.: evidence from wavelet analysis
Alper ASLAN, Nicholas APERGIS, Selim YILDIRIM
期刊论文
Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graph
Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang
期刊论文
Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known
null
期刊论文
Relationship between electricity consumption and economic growth of Guangdong Province in China
Lianhong LV, Hong LUO, Baoliu ZHANG
期刊论文
免疫球蛋白G N-糖基化与代谢特征之间的双向因果关联——一项孟德尔随机化研究
孟晓妮, 曹维杰, 刘迪, Isinta Elijah Maranga, 邢薇佳, 侯海峰, 徐希柱, 宋曼殳, 王友信
期刊论文
“暗”,不止于“深”——迈向认知智能与类人常识的范式转换
朱毅鑫, 高涛, 范丽凤, 黄思远, Mark Edmonds, 刘航欣, 高枫, 张驰, Siyuan Qi, 吴英年, Joshua B. Tenenbaum, 朱松纯
期刊论文