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2010 2

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Research advances of Legionella and Legionnaires’ disease

Xiao-Yong ZHAN MD, Chao-Hui HU PhD, Qing-Yi ZHU MD,

《医学前沿（英文）》 2010年第4卷第2期页码 166-176 doi: 10.1007/s11684-010-0036-3

摘要： is a causative agent of legionellosis or Legionnaires’ disease. Infection with spp. is an important cause of community and hospital-acquired pneumonia. Moreover, infection with is one of the most common causes of severe pneumonia in community settings, and is isolated in 40% of hospital-acquired pneumonia cases. The clinical features of legionellosis or Legionnaires’ disease are not unique, which makes the diagnosis challenging. Macrolides and fluoroquinolones are the most widely used drugs in treatment. Early recognition, treatment and effective measures for prevention and control of the disease are important and required. Although there have been a lot of methods for diagnosis of infection, they were often time-consuming or complex, not suitable for clinical purposes. This review summarizes available information regarding the microbiology, taxonomy, epidemiology, pathogenesis and diagnosis of Legionnaires’ disease, with an emphasis on the laboratory diagnosis of infection with spp.

关键词： Legionella Legionella pneumophila diagnosis Legionnaires’ disease

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Identification of Legionella species by the composition of cellular fatty acids

Cun-Lei FANG MD, Zhao-Hui HU PhD, Qing-Yi ZHU MD, Ya-Jun SONG PhD, Ya-Fang TAN PhD, Rui-Fu YANG PhD,

《医学前沿（英文）》 2010年第4卷第2期页码 208-215 doi: 10.1007/s11684-010-0031-8

摘要： One hundred and fifty-three isolates from the environment and 36 reference strains of the were studied with regards to their composition of cellular fatty acids as determined by gas chromatography, and then were classified into 41 groups by numerical analysis. Most reference strains formed only a single group, except , , , , and , which were clustered into two or three groups. Even serological types of could be clearly identified. Therefore, in this study, numerical analysis of cellular fatty acid composition is an effective method for identifying species.

关键词： Legionella numerical analysis identification fatty acids composition