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《医学前沿(英文)》 2022年 第16卷 第6期 页码 919-931 doi: 10.1007/s11684-021-0918-6
关键词: preeclampsia recombinant protein diannexin microparticle NLRP3 inflammasome phosphatidylserin
Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 235-240 doi: 10.1007/s11684-010-0002-0
Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng
《医学前沿(英文)》 2018年 第12卷 第5期 页码 542-549 doi: 10.1007/s11684-017-0576-x
Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulated coagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation and suppression of platelet aggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collected chorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20 and its phosphorylated form. Both HSP20 and phosphorylated HSP20 were downregulated in CPAs from women with PE. Comparison of the vasodilative ability of CPAs from the two groups showed impaired relaxation responses to acetyl choline in preeclamptic vessels. In addition to the reduced HSP20 in serum from women with PE, the platelet distribution width and mean platelet volume were also decreased, and the activated partial thromboplastin time and thromboplastin time were elevated. With regard to the vital roles of HSP20 in mediating vasorelaxation and coagulation function, the decreased HSP20 might contribute to the pathogenesis of PE.
关键词: preeclampsia heat shock protein 20 vascular relaxation coagulation-fibrinolytic system
标题 作者 时间 类型 操作
Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing
期刊论文
Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia
Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,
期刊论文