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《医学前沿（英文）》 2015年 第9卷 第1期 页码 46-56 doi: 10.1007/s11684-015-0375-1
Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.
关键词： oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
Right coronary occlusion following transcatheter aortic valve implantation: two case reports
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《医学前沿（英文）》 2016年 第10卷 第3期 页码 351-355 doi: 10.1007/s11684-016-0465-8
This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.
关键词： aortic stenosis transcatheter aortic valve implantation right coronary occlusion cardiac group
基于RGBD和稀疏学习的鲁棒目标跟踪 Article
Zi-ang MA, Zhi-yu XIANG
《信息与电子工程前沿（英文）》 2017年 第18卷 第7期 页码 989-1001 doi: 10.1631/FITEE.1601338
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《医学前沿（英文）》 2011年 第5卷 第1期 页码 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
关键词： adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Actor-Critic强化学习算法及其在开发基于计算机视觉的界面跟踪中的应用 Article
Oguzhan Dogru, Kirubakaran Velswamy, 黄彪
《工程（英文）》 2021年 第7卷 第9期 页码 1248-1261 doi: 10.1016/j.eng.2021.04.027
本文通过将对象跟踪形式化为序列决策过程，使控制理论与计算机视觉实现同步。强化学习（RL）智能体成功跟踪了两种液体之间的界面，这通常是化学、石化、冶金和石油行业中跟踪的关键变量。该方法使用少于100 张图像来创建环境，智能体无需专家知识即可从中生成自己的数据。与依赖大量参数的监督学习（SL）方法不同，这种方法需要的参数少得多，这自然降低了维护成本。除了经济性外，该智能体还对环境不确定性（如遮挡、强度变化和过度噪声）具有鲁棒性。在闭环控制情境下，基于界面位置的偏差被选作训练阶段的优化目标。该方法展示了RL方法在油砂行业中的实时对象跟踪应用。本文除了介绍界面跟踪问题外，还详细回顾了最有效的RL方法之一——actor-critic策略。
标题 作者 时间 类型 操作
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
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期刊论文
Right coronary occlusion following transcatheter aortic valve implantation: two case reports
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期刊论文
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion
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期刊论文
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