Kinetics of halogen-exchange fluorination of 2,6-dichlorobenzaldehyde

2008, Volume 2, Issue 1

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Frontiers of Chemical Science and Engineering >> 2008, Volume 2, Issue 1 doi: 10.1007/s11705-008-0008-1

Kinetics of halogen-exchange fluorination of 2,6-dichlorobenzaldehyde

College of Chemical Engineering, Nanjing University of Science & Technology;

Available online: 2008-03-05

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Abstract

Under the conditions of phase transfer catalysis and nitrobenzene as the solvent, the halogen-exchange fluorination of 2,6-dichlorobenzaldehyde using KF as fluorinating agent was studied. The kinetics was investigated and the reaction rate constants were obtained under the optimum conditions of (KF):(2,6-dichlorobenzaldehyde):(PhPBr):n(acetone-furan crown ether) = 4:1:0.1:0.05 and temperatures of 433 K, 443 K, 453 K and 463 K. The results illustrated the activation energy of the first and the second step is 4.57 × 10 J·mol and 3.53 × 10 J·mol, respectively. The pre-exponential factor is 4.50 × 10 h and 1.08 × 10 h, respectively. Thus a reliable kinetics data could be obtained for further research.

Keywords

reaction ; solvent ; transfer catalysis ; activation ; nitrobenzene

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