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Primary cilia in hard tissue development and diseases

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 657-678 doi: 10.1007/s11684-021-0829-6

Abstract: Primary cilia are protrusions on the surfaces of cells.Furthermore, primary cilia act as sensors of external stimuli and regulate bone homeostasis.In this review, we summarize the roles of primary cilia in long bone development and remodeling fromtwo perspectives: primary cilia signaling and sensory mechanisms.In addition, the cilium-related diseases of hard tissue and the manifestations of mutant cilia in the

Keywords： primary cilia     bone     mechanical sensing     hard tissue     cilium-related bone disease     tooth    

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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Frontiers of Medicine doi: 10.1007/s11684-023-0997-7

Abstract: Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54, the homolog of CFAP54 in Chlamydomonas reinhardtii, was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella. A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes. Through whole-exome sequencing, compound heterozygous variants c.2649_2657delinC (p. E883Dfs*47) and c.7312_7313insCGCAGGCTGAATTCTTGG (p. T2438delinsTQAEFLA) in a new suspected PCD-relevant gene, CFAP54, were identified in an individual with PCD. Two missense variants, c.4112A>C (p. E1371A) and c.6559C>T (p. P2187S), in CFAP54 were detected in another unrelated patient. In this study, a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression. In addition, a CFAP54 in-frame variant knock-in mouse model was established, which recapitulated the typical symptoms of PCD, including hydrocephalus, infertility, and mucus accumulation in nasal sinuses. Correspondingly, two missense variants were deleterious, with a dramatic reduction in mRNA abundance from bronchial tissue and sperm. The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene. This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future.

Keywords： primary ciliary dyskinesia     CFAP54     cilia    

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Flagellar/Ciliary Intrinsic Driven Mechanism Inspired All-in-One Tubular Robotic Actuator Article

Jiaqi Miao, Tieshan Zhang, Gen Li, Dong Guo, Siqi Sun, Rong Tan, Jiahai Shi, Yajing Shen

Engineering 2023, Volume 23, Issue 4,   Pages 170-180 doi: 10.1016/j.eng.2022.09.014

Abstract:

The unique motion styles of flagella and cilia (i.e., planar/helical waveform propulsion of flagellaHerein, by investigating the inner structure of flagella/cilia and their intrinsic driven mechanisms,

Keywords： Biomimetic systems     Soft actuators     9 + 2 structure     Artificial cilia     Low Reynolds number    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile ciliaBased on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants areImmunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory ciliarevealed strikingly disordered axoneme 9+2 architecture and inner dynein arm defects in the respiratory cilia

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Applications of traditional pump design theory to artificial heart and CFD simulation

WANG Yingpeng, SONG Xinwei, YING Chuntong

Frontiers in Energy 2008, Volume 2, Issue 4,   Pages 504-507 doi: 10.1007/s11708-008-0059-5

Abstract: traditional axial pump design theory with the consideration of working and hydraulic situations for artificialThe results show that this procedure can be used for designing a series of high-efficiency artificial

Keywords： computational     high-efficiency artificial     iterative approach     artificial     traditional    

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INTERACTIVE KNOWLEDGE LEARNING BY ARTIFICIAL INTELLIGENCE FOR SMALLHOLDERS

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 4,   Pages 648-653 doi: 10.15302/J-FASE-2023505

Abstract: Therefore, this article proposes an interactive knowledge learning approach using artificial intelligence

Keywords： artificial intelligence     extension system     non-point source pollution control     smallholders     fertilization    

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Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 511-517 doi: 10.1007/s11684-020-0742-4

Abstract: Artificial intelligence (AI) is coming to medicine in a big wave.

Keywords： artificial intelligence     endoscopy     robotics     gastrointestinal diseases    

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The Tong Test: Evaluating Artificial General Intelligence Through Dynamic Embodied Physical and Social

Yujia Peng,Jiaheng Han,Zhenliang Zhang,Lifeng Fan,Tengyu Liu,Siyuan Qi,Xue Feng,Yuxi Ma,Yizhou Wang,Song-Chun Zhu,

Engineering doi: 10.1016/j.eng.2023.07.006

Abstract: The release of the generative pre-trained transformer (GPT) series has brought artificial general intelligence(AGI) to the forefront of the artificial intelligence (AI) field once again.

Keywords： Artificial general intelligence     Artificial intelligence benchmark     Artificial intelligence evaluation     Embodied artificial intelligence     Value alignment     Turing test     Causality    

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Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Frontiers in Energy 2021, Volume 15, Issue 3,   Pages 568-576 doi: 10.1007/s11708-021-0774-8

Abstract: Solar hydrogen production by water splitting using a photocatalyst as artificial photosynthesis is a

Keywords： visible light responsive photocatalyst     water splitting     artificial photosynthesis: metal ion substitution    

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Special issue: Innovative applications of big data and artificial intelligence

Frontiers of Engineering Management 2022, Volume 9, Issue 4,   Pages 517-519 doi: 10.1007/s42524-022-0234-0

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What will the future hold for artificial organs in the service of assisted reproduction: prospects and

Mara Simopoulou, Konstantinos Sfakianoudis, Petroula Tsioulou, Anna Rapani, Polina Giannelou, Nikolaos Kiriakopoulos, Agni Pantou, Nikolaos Vlahos, George Anifandis, Stamatis Bolaris, Konstantinos Pantos, Michael Koutsilieris

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 627-638 doi: 10.1007/s11684-019-0697-5

Abstract: Cutting edge research on animal models introduced this concept, along with the development of artificialTo date, the successful clinical application of artificial reproductive organs in humans is not feasibleThe application of these artificial organs could provide a solution to infertility cases with no otheron the current status, future prospects, and considerations on the potential clinical application of artificial

Keywords： artificial ovary     artificial uterus     artificial gametes     assisted reproduction     considerations     in vitro    

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HIGH-PERFORMANCE COMPUTATION AND ARTIFICIAL INTELLIGENCE IN PESTICIDE DISCOVERY: STATUS AND OUTLOOK

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 150-154 doi: 10.15302/J-FASE-2021419

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Predicting the strength properties of slurry infiltrated fibrous concrete using artificial neural network

T. Chandra Sekhara REDDY

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 4,   Pages 490-503 doi: 10.1007/s11709-017-0445-3

Abstract: This paper is aimed at adapting Artificial Neural Networks (ANN) to predict the strength properties of

Keywords： artificial neural networks     root mean square error     SIFCON     silica fume     metakaolin     steel fiber    

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Wastewater treatment meets artificial photosynthesis: Solar to green fuel production, water remediation

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 4, doi: 10.1007/s11783-022-1536-5

Abstract:

• Mitigating energy utilization and carbon emission is urgent for wastewater treatment.

Keywords： Wastewater treatment     Artificial photosynthesis     Microbial photoelectrochemical (MPEC) system     Carbon    

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Interaction behavior and load sharing pattern of piled raft using nonlinear regression and LM algorithm-based artificial

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1181-1198 doi: 10.1007/s11709-021-0744-6

Abstract: The obtained results are then checked statistically with nonlinear multiple regression (NMR) and artificial

Keywords： interaction     load sharing ratio     piled raft     nonlinear regression     artificial neural network    

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Title Author Date Type Operation

Primary cilia in hard tissue development and diseases

Journal Article

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Journal Article

Flagellar/Ciliary Intrinsic Driven Mechanism Inspired All-in-One Tubular Robotic Actuator

Jiaqi Miao, Tieshan Zhang, Gen Li, Dong Guo, Siqi Sun, Rong Tan, Jiahai Shi, Yajing Shen

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Applications of traditional pump design theory to artificial heart and CFD simulation

WANG Yingpeng, SONG Xinwei, YING Chuntong

Journal Article

INTERACTIVE KNOWLEDGE LEARNING BY ARTIFICIAL INTELLIGENCE FOR SMALLHOLDERS

Journal Article

Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

Journal Article

The Tong Test: Evaluating Artificial General Intelligence Through Dynamic Embodied Physical and Social

Yujia Peng,Jiaheng Han,Zhenliang Zhang,Lifeng Fan,Tengyu Liu,Siyuan Qi,Xue Feng,Yuxi Ma,Yizhou Wang,Song-Chun Zhu,

Journal Article

Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Journal Article

Special issue: Innovative applications of big data and artificial intelligence

Journal Article

What will the future hold for artificial organs in the service of assisted reproduction: prospects and

Mara Simopoulou, Konstantinos Sfakianoudis, Petroula Tsioulou, Anna Rapani, Polina Giannelou, Nikolaos Kiriakopoulos, Agni Pantou, Nikolaos Vlahos, George Anifandis, Stamatis Bolaris, Konstantinos Pantos, Michael Koutsilieris

Journal Article

HIGH-PERFORMANCE COMPUTATION AND ARTIFICIAL INTELLIGENCE IN PESTICIDE DISCOVERY: STATUS AND OUTLOOK

Journal Article

Predicting the strength properties of slurry infiltrated fibrous concrete using artificial neural network

T. Chandra Sekhara REDDY

Journal Article

Wastewater treatment meets artificial photosynthesis: Solar to green fuel production, water remediation

Journal Article

Interaction behavior and load sharing pattern of piled raft using nonlinear regression and LM algorithm-based artificial

Journal Article