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Research on the Significance of Developing New Energy Vehicles Industry and Its Technical Routes

Chen Qingquan,Gao Jinyan,He Xuan and Shen Bin

Strategic Study of CAE 2018, Volume 20, Issue 1,   Pages 68-73 doi: 10.15302/J-SSCAE-2018.01.010

Abstract:

This study first analyzes the significance of developing a new industry with respect to energy, environment

Keywords： new energy vehicle     major significance     technical route     measures    

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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable. To investigate the biological behavior of GIST, we collected 83 cases of gastric and 62 cases of small intestinal GIST from the Department of Pathology of the Chinese PLA General Hospital. The parameters include age, primary tumor location, tumor diameter, mitotic index, tumor necrosis, risk assessment, clinical stage and the exon 11 mutation. All these were analyzed in 105 cases along with the follow-up data and tested by log rank and COX hazard proportional model. We find that the average age of gastric GIST was 55.4 years. Of the 62 cases that were followed up, 17 cases had metastasis or recurrence and the 5-year survival rate was (66.51 ± 17.06)%. For the small intestinal GIST, the average age was 50.6 years and 43 cases were followed up. Of these, 22 cases had metastasis or recurrence and the 5-year survival rate was (61.76 ± 18.30)%. Small intestinal GIST was more frequently associated with metastasis and tumor relapse than gastric GIST ( = 6.131, = 0.013). For gastric GIST, patients younger than 50 years ( = 0.046), the advanced clinical stage ( = 0.0001), the large tumor diameter ( = 0.0001), a high mitotic index ( = 0.0001), necrosis ( = 0.0001) and a high risk grade ( = 0.004) were all correlated with a lower survival rate. The COX hazard proportional model revealed that advanced clinical stage ( = 0.001), large tumor size ( = 0.001), a high mitotic index ( = 0.002) and the high risk grade ( = 0.018) indicated a poorer prognosis in gastric GIST. For small intestinal GIST, necrosis ( = 0.036) and advanced clinical stage ( = 0.010) were associated with lower survival rates and the clinical stage was shown to be an independent prognostic indicator. A total of 25 cases harbored mutations in exon 11. The frequency of mutation was 32% and 22.5% for gastric and small intestinal GIST, respectively. In gastric GIST, the mutated was predominant in patients older than 50 years of age. But in the small intestinal GIST, the mutated was predominant in the age group of 40–49 years. In conclusion, for gastric GIST, clinical stage, tumor size, mitotic index, and risk grade are the prognostic indicators. For small intestinal GIST, necrosis and clinical stage are the prognostic indicators. Small intestinal GIST are more aggressive than gastric GIST. The occurrence of mutation may correlate with the age of patients.
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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 364-368 doi: 10.1007/s11684-007-0070-y

Abstract: The aim of this article was to study the influence of immunity function of advanced malignant obstructive jaundice (MOJ) treated by percutaneous transhepatic biliary external and internal drainage. Ninety-six cases of MOJ were divided into two groups according to the different ways of biliary drainage. Fifty-two external drainage tubes were placed in 41 cases of percutaneous transhepatic biliary external drainage group and 66 metal stents were placed in 55 cases of percutaneous transhepatic biliary internal drainage group. Liver function, serum TNF- and cellular function were examined one day before operation and one week after operation and liver function was re-examined two weeks after operation, in order to observe the change and analyze the asso ciation among them and compare with the control group. All patients conditions were improved after operation. In the percutaneous transhepatic biliary external and internal drainage groups, the total level of bilirubin decreased from (343.54±105.56) μ mol/L and (321.19±110.50) μ mol/L to (290.56±103.46) μ mol/L and (283.72±104.95) μ mol/L after operation respectively, which were significantly lower than pre-operation (<0.05), but there was no significant difference between the two groups (>0.05). Serum alanine aminotransferase (ALT) of all patients one week after operation was significantly lower than that before operation. TNF- in percutaneous transhepatic biliary external and internal groups decreased from (108.58±19.95) pg/mL, (109.98±16.24) pg/mL of pre-operation to (104.32±19.59) pg/mL, (83.92±13.43) pg/mL of post-operation respectively, there was notable improvement (<0.01) in internal drainage group after operation. Patients serum CD4, CD3 and CD4/CD8 were notably increased, but CD8 was notably decreased (<0.05). There was no difference in external drainage group (>0.05). There was a significant difference between the two groups. Serum TNF- and ALT had positive correlation. Percutaneous transhepatic biliary internal or external drainage was an effective and important method to treat MOJ. Patients immune function was weak when they suffered MOJ, but body s cellular immune function can be notably improved after internal biliary drainage.
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The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 343-348 doi: 10.15302/J-FEM-2016053

Abstract: This paper discusses the two major root causes of smog in China.The second major cause of smog is the low quality diesel and outdated diesel engines used in China.

Keywords： smog     emissions     coal refining     coal utilization     solutions    

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Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 528-540 doi: 10.1007/s11684-020-0798-1

Abstract: Major depressive disorder (MDD) causes great decrements in health and quality of life with increments

Keywords： psychoradiology     major depressive disorder     MRI     biomarker    

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract:

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

Keywords： gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

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Arbuscular mycorrhizal associations and the major regulators

Li XUE, Ertao WANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 296-306 doi: 10.15302/J-FASE-2020347

Abstract:

Plants growing in natural soils encounter diverse biotic and abiotic stresses and have adapted with sophisticated strategies to deal with complex environments such as changing root system structure, evoking biochemical responses and recruiting microbial partners. Under selection pressure, plants and their associated microorganisms assemble into a functional entity known as a holobiont. The commonest cooperative interaction is between plant roots and arbuscular mycorrhizal (AM) fungi. About 80% of terrestrial plants can form AM symbiosis with the ancient phylum Glomeromycota. A very large network of extraradical and intraradical mycelium of AM fungi connects the underground biota and the nearby carbon and nutrient fluxes. Here, we discuss recent progress on the regulators of AM associations with plants, AM fungi and their surrounding environments, and explore further mechanistic insights.

Keywords： AM symbiosis     signal     regulators     nutrients     phosphate     microbiota    

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Life cycle and performance based seismic design of major bridges in China

FAN Lichu

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 3,   Pages 261-266 doi: 10.1007/s11709-007-0033-z

Abstract: The idea of life cycle and performance based seismic design of major bridges is introduced.components, different seismic design levels and expected performance objectives are suggested for the majorassessment, are also proposed to be the important issues to study in order to guide the seismic design of major

Keywords： controllability     progressive     reparability     different     important    

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Progress on major genes for high fecundity in ewes

Qiuyue LIU,Zhangyuan PAN,Xiangyu WANG,Wenping HU,Ran DI,Yaxing YAO,Mingxing CHU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 282-290 doi: 10.15302/J-FASE-2014042

Abstract: The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstratedThree major genes whose mutations can increase ovulation rate have been discovered, and all related toIn addition, several putative major genes need to be verified.This review is focused on the identification of the mutations and mechanisms whereby the major genes

Keywords： major gene     ovulation rate     sheep     reproduction    

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Value Management Practices on Major Construction Projects and Green Building

Ru-jiang Zhao,Wung Hee Moh

Frontiers of Engineering Management 2016, Volume 3, Issue 2,   Pages 147-157 doi: 10.15302/J-FEM-2016018

Abstract: The paper starts with background information on value management (VM) in the construction industry and current development situation of the green building industry, and costs and profitability of green buildings. The paper continues with detailed analyses of the findings, covering new developments and perceptions of VM, and applications of VM in the industry. The paper also reports case studies on the practices adopted in the planning and design management phase of SIPO Guangdong Patent Examination Cooperation Center and in the construction management phase of Guangzhou International Bio-Island Standard Property Unit II project. As revealed by the practices, the value-adds and savings in construction costs through the application of VM are important for the developers, and the contributions of VM application in green building projects are significant to achieving the expected targets and to resolving the design and construction challenges encountered in the development of green building industry. And the paper presents, findings on how VM can improve construction management and coordination of several ongoing construction projects and on how VM can be systematically implemented by phases, and discussions on other potential benefits of using VM systems.

Keywords： value management (VM)     VM theory and practices     Chinese construction industry     green buildings    

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Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 487-495 doi: 10.1007/s11684-015-0413-z

Abstract: This study aimed to investigate the temporal trend of eight major cancers in Xuanwei County using datastudies are warranted to systematically examine the underlying reasons for the temporal trend of the major

Keywords： cancer     mortality     Xuanwei     temporal trend    

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Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 445-454 doi: 10.1007/s11709-009-0063-9

Abstract: Based on the study of ancient maps preserved in China and abroad, the systematic nature and practical meaning of the maps of the Yellow River and Grand Canal is demonstrated. It is pointed out that the ancient maps not only record the spatial information of the established water conservancy engineering for river harnessing but also the management systems of the rivers in history. Besides, the maps provide abundant information on nature, humanity, and geography and possess high value in academic research and art appreciation.

Keywords： information     management     established     appreciation     practical    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical lesions have been regarded as the common and frequently occurring diseases in China. Recently, the morbidity and youth tendency of cervical cancer have gradually increased. Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases threatening health and life of women, and is an infectious disease. The universality of HPV infection in the reproductive tract should not be ignored. The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors, immunosuppression, age, contraceptive methods, the concurrent infection of other sexually transmitted diseases, etc. The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process, including the subclinical, latent, and persistent infection of high risk (HR)-HPV, chronic cervicitis with abnormal results of cytological examination, cervical intraepithelial neoplasia (CIN), and cervical cancer. The outcome of patients with HPV infection is influenced by many factors, such as HPV subtype dominance, persistent HPV infection, HPV loading dose, and multiple HPV infection. Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial neoplasia     cervical cancer    

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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 4,   Pages 385-396 doi: 10.1007/s11783-008-0073-1

Abstract: microbiological treatment methods are, only to a limited part, able to satisfy these needs, the role and significance

Keywords： control     beneficial     valuable     scarcity     Development    

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Title Author Date Type Operation

Research on the Significance of Developing New Energy Vehicles Industry and Its Technical Routes

Chen Qingquan,Gao Jinyan,He Xuan and Shen Bin

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Journal Article

The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Journal Article

Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

Journal Article

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Journal Article

Arbuscular mycorrhizal associations and the major regulators

Li XUE, Ertao WANG

Journal Article

Life cycle and performance based seismic design of major bridges in China

FAN Lichu

Journal Article

Progress on major genes for high fecundity in ewes

Qiuyue LIU,Zhangyuan PAN,Xiangyu WANG,Wenping HU,Ran DI,Yaxing YAO,Mingxing CHU

Journal Article

Value Management Practices on Major Construction Projects and Green Building

Ru-jiang Zhao,Wung Hee Moh

Journal Article

Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Journal Article

Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Journal Article