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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new categorydiscuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon developmentof drug resistance.We discuss the development of sequential drug therapies in which the first therapy is not given withcurative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively

Keywords： cancer drug resistance genetic screens senescence targeted therapy

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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1, Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: It involves new drug research and development, innovation of traditional Chinese medicineTo promote the new drug research and development based on integrative pharmacy, the design idea of integrative,and a new drug development system should be established for integrative drugs.It is a new pharmacy theory and practice system that can promote human health and improve the existing

Keywords： integrative pharmacy integrative drugs new drug development drug evaluation clinical medication guidance

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Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3, Pages 362-368 doi: 10.1007/s11705-014-1439-5

Abstract: components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drugquantitative composition-activity relationships in order to optimize the amount of each component in the drug

Keywords： multi-component drug development central composite design turmeric curcuminoids

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Concepts for the Construction of a New National Drug Service System

Wang Jian,Yuan Chunping,Wang Hao,Zhang Zhirong,Zhang Qiang,Chen Guiliang,Liu Changxiao,Hou Huimin and Yang Shengli

Strategic Study of CAE 2017, Volume 19, Issue 2, Pages 62-67 doi: 10.15302/J-SSCAE-2017.02.010

Abstract:

Although the current drug service system can meet the fundamental needsof healthcare in China, outstanding issues exist in all service sectors, including research and developmentspecialist consultation, and a panel discussion, this study investigated the current status of the drugWe propose an idea for constructing a new national drug service system to provide drugs to the Chinese

Keywords： drug service system pharmaceutical industry supervision development strategy

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonarydrug delivery (PDD).leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering improved pressure aqueous technique

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussedFinally, future prospects of developing new and better semi-solid excipients are discussed with the objective

Keywords： controlled release drug delivery semi-solids polymer excipient

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Underground logistics systems: Development overview and new prospects in China

Frontiers of Engineering Management 2023, Volume 10, Issue 2, Pages 354-359 doi: 10.1007/s42524-023-0252-6

Abstract: Underground logistics systems: Development overview and new prospects in China

Keywords： China

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite hollow spheres synthesis drug release

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The development trend and practical innovation of smart cities under the integration of new technologies

Xiaohong CHEN

Frontiers of Engineering Management 2019, Volume 6, Issue 4, Pages 485-502 doi: 10.1007/s42524-019-0057-9

Abstract: Smart cities have rapidly developed in the context of the integration of new digital technologies such

Keywords： new technology integration smart city big data practical innovation

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Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial

Feng Qi, Jie Wu, Hao Li, Guanghui Ma

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1, Pages 14-27 doi: 10.1007/s11705-018-1729-4

Abstract: There have been 15 products available on the US market, but the system still has many problems during developmentRecently, many new and modified methods have been developed to overcome the above problems.Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated newdrug application.The review provides an overview on the development of the system in pharmaceutical industry.

Keywords： PLGA microspheres drug delivery system stability manufacturing

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China

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Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesEach was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effectsThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyThe clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:

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Strategy research on urban new space development and new deepwater port in Hengsha

Bao Qifan,Ren Guohua

Strategic Study of CAE 2013, Volume 15, Issue 6, Pages 14-19

Abstract: Construction of new deep-water terminal is the best usage of land resources and can strengthen the statusinternational shipping center, thus supporting the preparation and strategic decision of future urban development

Keywords： urban development new space deepwater port strategy research