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based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: A double-blind, randomized, and placebo-controlled trial was conducted for 24 weeks, in which 96 patients

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: All available published data of randomized clinical trials comparing transurethral resection plus intravesicalstatistically significant difference in the s for tumor recurrence between the two treatment groups was found (randomizedThe randomized model combined effect of Pasteur F and other strains were 0.50 (95% CI 0.26 to 0.95,
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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomizedplacebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract: All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthmaRandomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative

Keywords： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in ChinaAmong the 371 randomized subjects, a similar percentage of subjects treated with FCM and IS achieved

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 112-116 doi: 10.1007/s11684-010-0016-7

Abstract: This randomized controlled trial was performed on 158 cervical cancer patients in our hospital between

Keywords： cervical cancer     radical surgery     peritoneum     subcutaneous tissue    

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older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 368-375 doi: 10.1007/s11684-014-0360-0

Abstract: older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomizedcontrolled trial.

Keywords： chronic obstructive pulmonary disease     older adult     clinical trial     Bu-Fei Jian-Pi granules     Bu-Fei Yi-Shen granules     Yi-Qi Zi-Shen granules    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targetedPUBMED and EMBASE databases were searched for eligible trials.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 486-494 doi: 10.1007/s11684-020-0824-3

Abstract: We conducted a randomized, controlled, open-label multicenter trial among COVID-19 patients.Thirty-three patients were randomized to the tocilizumab group, and 32 patients to the control group.

Keywords： tocilizumab     coronavirus disease 2019 (COVID-19)     cytokine storm    

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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: A randomized, double-blinded, placebo-controlled trial was performed.

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 704-717 doi: 10.1007/s11684-021-0853-6

Abstract: We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian

Keywords： COVID-19     SARS-CoV-2     Shuanghuanglian oral liquid     clinical trial    

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Consolidated standards of reporting trials (CONSORT) for traditional Chinese medicine: current situation

Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 171-177 doi: 10.1007/s11684-011-0132-z

Abstract: The reporting standards for randomized controlled trials were first published in 1996 by a group of scientistsunder the name “CONSORT,” which means consolidated standards of reporting trials.

Keywords： CONSORT for TCM     reporting standards     future development    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean sensor glucose    

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Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 498-510 doi: 10.1007/s11705-014-1451-9

Abstract: Design of biocompatible and biodegradable polymer systems for sustained and controlled release of bioactiveHere, we designed, synthesized, and characterized four polyurethane carrier systems for controlled release

Keywords： phase structure     degradation     polyurethanes     controlled release     drug delivery    

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Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 39-46

Abstract:

This study aimed at exploring a new 3-dimensional reticular intrauterine device (3-DR-IUD) composed of nitinol and silicone rubber and observing the contraceptive efficacy and side effects of the device in reproductive women. The frame of the 3-DR-IUD was constructed with silicone rubber and nitinol wire. The 3-DR-IUD was placed into uterus in an outpatient procedure. One hundred and fifty- two women were divided equally into the 3-DR-IUD group (n=76) and the 2- dimensional intrauterine device (2- D- IUD) group (n=76，control group). Patient follow-ups were performed in 1～12 months post-operation. The side effects of intrauterine device (IUD)，such as abnormal leucorrhea，menstrual flow changes in uterine bleeding profusely and pain，etc，were investigated. The pregnancy rate，expulsion rate，removal rate of IUD for medical reasons and the continuation rate were evaluated. The ultrasound and pelvic X-ray were carried out to examine IUDs. The results showed that two groups with 76 cases of each successfully placed IUD and there were no severe pain during the operation. The incidence of lumbago/abdominal pain and the occurrence of leucorrhea and irregular vaginal bleeding in the 3-DR-IUD group (7.9 %，6/76) were significantly lower than that of the 2-DIUD group (40.8 %，31/76) during the first 12 months for use of IUD (P<0.000 1). The pregnancy rate，expulsion rate and take-off rate due to symptom were 0 %，0 % and 1.3 % in 3-DRIUD group，respectively，and 1 of 76 woman take-off 3-DR-IUD was due to allergy for silicon rubber. The continuation rate was 98.7 % (75/76) in the 3-DR-IUD group，comparing with the 2-D-IUD group (86.8 % ，66/76)，the difference was significantly (P=0.009). Therefore，the 3-DR-IUD demonstrates long-term patient tolerability，satisfaction and efficacy as a contraceptive.The 3-DR-IUD appears to be a new，safe and effective devise of contraception.

Keywords： 3-DR-IUD     clinical trials     side effects     contraceptive efficacy    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: biomarkers for prognosis/efficacy, and inability to identify potential novel therapies in clinical trials

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Title Author Date Type Operation

based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

Journal Article

A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomizedplacebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Journal Article

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Journal Article

older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Journal Article

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

Journal Article

Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Journal Article

Consolidated standards of reporting trials (CONSORT) for traditional Chinese medicine: current situation

Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

Journal Article

Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Journal Article

Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article