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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 1,   Pages 8-16 doi: 10.1007/s11709-016-0365-7

Abstract: Results prompt the consideration of more consistent guidance on and enforcement of turn indicator use

Keywords： roundabouts     exiting vehicles     turn indicator use     headways    

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Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2,   Pages 211-218 doi: 10.1007/s11783-012-0464-1

Abstract: to assess the impacts of proposed Severn Barrage on the hydrodynamic, sediment transport and faecal indicator

Keywords： water quality indicator     Severn Estuary     numerical model     tidal energy    

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Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 5,   Pages 678-691 doi: 10.1007/s11783-012-0450-7

Abstract: environment management, a systematic approach, encompassing several steps including establish ideal indicatorand organize discussion workshop, should be followed to establish a comprehensive water environment indicatorrelating to water environment security as well as design an appropriate water environment security indicator

Keywords： water environment security     supervision and management     monitoring parameter     indicator system     Suzhou    

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CONSTRUCTION OF AN INDEX SYSTEM FOR SUSTAINABILITY ASSESSMENT IN SMALLHOLDER FARMING SYSTEMS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 4,   Pages 511-522 doi: 10.15302/J-FASE-2022463

Abstract:

● A five-step process for quantifying smallholder farming system sustainability is proposed.

Keywords： indicator aggregation     multi-indicator     smallholder agriculture     sustainability assessment     weighting    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract:

Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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Nonlinear dynamic behavior of rotating blade with breathing crack

Laihao YANG, Zhu MAO, Shuming WU, Xuefeng CHEN, Ruqiang YAN

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 1,   Pages 196-220 doi: 10.1007/s11465-020-0609-z

Abstract: dynamic behavior of rotating cracked blade is then investigated with NRCBM, and the nonlinear damage indicatorThe results show that NDI is a distinguishable indicator for the severity level estimation of the crackindicators for diagnosing the crack existence, and the third-order super-harmonic resonances can serve as an indicator

Keywords： rotating blade     breathing crack     nonlinear vibration     nonlinear damage indicator    

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Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 122-128 doi: 10.1007/s11783-008-0023-y

Abstract: Macroinvertebrates are important components of stream ecosystems, and are often used as indicator species

Keywords： Substrata     physical environmental     indicator     ecology     substrate    

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of the situational awareness effects for smart distribution networks under the novel design of indicator

Leijiao GE, Yuanliang LI, Suxuan LI, Jiebei ZHU, Jun YAN

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 143-158 doi: 10.1007/s11708-020-0703-2

Abstract: Besides, to implement the indicator framework while addressing the key issues of human expert scoring

Keywords： distribution networks     operation and maintenance     expert systems    

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Marine target detection based on Marine-Faster R-CNN for navigation radar plane position indicator images Research Article

Xiaolong CHEN, Xiaoqian MU, Jian GUAN, Ningbo LIU, Wei ZHOU,cxlcxl1209@163.com,guanjian_68@163.com

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 4,   Pages 630-643 doi: 10.1631/FITEE.2000611

Abstract: As a classic deep learning target detection algorithm, Faster R-CNN (region convolutional neural network) has been widely used in high-resolution synthetic aperture radar (SAR) and inverse SAR (ISAR) image detection. However, for most common low-resolution radar , it is difficult to achieve good performance. In this paper, taking PPI images as an example, a method based on the Marine-Faster R-CNN algorithm is proposed in the case of complex background (e.‍g., sea clutter) and target characteristics. The method performs feature extraction and target recognition on PPI images generated by radar echoes with the . First, to improve the accuracy of detecting marine targets and reduce the false alarm rate, Faster R-CNN was optimized as the Marine-Faster R-CNN in five respects: new backbone network, anchor size, dense target detection, data sample balance, and scale normalization. Then, JRC (Japan Radio Co., Ltd.) was used to collect echo data under different conditions to build a marine target dataset. Finally, comparisons with the classic Faster R-CNN method and the constant false alarm rate (CFAR) algorithm proved that the proposed method is more accurate and robust, has stronger generalization ability, and can be applied to the detection of marine targets for . Its performance was tested with datasets from different observation conditions (sea states, radar parameters, and different targets).

Keywords： Marine target detection     Navigation radar     Plane position indicator (PPI) images     Convolutional neural    

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SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 356-365 doi: 10.15302/J-FASE-2022458

Abstract:

● A composite N management index is proposed to measure agriculture sustainability.

Keywords： global assessment     indicator     nitrogen management     sustainable agriculture     sustainable development goals    

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Smart model for accurate estimation of solar radiation

Lazhar ACHOUR, Malek BOUHARKAT, Ouarda ASSAS, Omar BEHAR

Frontiers in Energy 2020, Volume 14, Issue 2,   Pages 383-399 doi: 10.1007/s11708-017-0505-3

Abstract: Prediction of solar radiation has drawn increasing attention in the recent years. This is because of the lack of solar radiation measurement stations. In the present work, 14 solar radiation models have been used to assess monthly global solar radiation on a horizontal surface as function of three parameters: extraterrestrial solar irradiance ( ), duration sunshine ( ) and daylight hours ( ). Since it has been observed that each model is adequate for some months of the year, one model cannot be used for the prediction of the whole year. Therefore, a smart hybrid system is proposed which selects, based on the intelligent rules, the most suitable prediction model of the 14 models listed in this study. For the test and evaluation of the proposed models, Tamanrasset city, which is located in the south of Algeria, is selected for this study. The meteorological data sets of five years (2000–2004) have been collected from the Algerian National Office of Meteorology (NOM), and two spatial databases. The results indicate that the new hybrid model is capable of predicting the monthly global solar radiation, which offers an excellent measuring accuracy of values ranging from 93% to 97% in this location.

Keywords： global solar radiation     statistical indicator     hybrid model     spatial database     correlation coefficients    

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Research on the evaluation creteria of green railway station

Zheng Jian

Strategic Study of Chinese Academy of Engineering 2012, Volume 14, Issue 12,   Pages 41-47

Abstract:

According to the investigation of national policy guidance, industrial development requirements, domestic and international recent situation of green railway and the system of green building evaluation, based on the third generation green building evaluation system, a set of criteria of green railway station evaluation for stations in different climatic regions with different scales has been established. The setting of this standard can enrich the study on standard of green building evaluation and even fill the gap in the field of green railway station assessment; it also has a promotion function in the development of green railway station evaluation.

Keywords： railway passenger station     green building     evaluation criteria     indicator system    

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Application of Hydrogen Peroxide as an Environmental Stress Indicator for Vegetation Management Article

Takashi Asaeda,Senavirathna Mudalige Don Hiranya Jayasanka,Li-Ping Xia,Abner Barnuevo

Engineering 2018, Volume 4, Issue 5,   Pages 610-616 doi: 10.1016/j.eng.2018.09.001

Abstract: The presence of reactive oxygen species (ROS) has long been used as an indicator of environmental stressThus, the quantification of plant H2O2 could be applied as a stress indicator forpresents an approach for elucidating the applicability of H2O2 as a quantitative indicatorThe results suggest that H2O2 can be conveniently applied as a stress indicator

Keywords： Macrophytes     Riparian zone     Environmental gradient     Stress indicator     Reactive oxygen species     Hydrogen peroxide    

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The Exploration and Practice of the Development of Green Eco-Urban Areas in Guangzhou International Financial City

Jia-meng Chen,Peng Liu

Frontiers of Engineering Management 2016, Volume 3, Issue 1,   Pages 87-96 doi: 10.15302/J-FEM-2016003

Abstract: comparing and analyzing existing research, development of green technologies at home and abroad, and indicatorsystems of green urban areas of similar sizes, the builders developed a green ecological indicator systemThey proposed a new concept called “district-level indicator” in order to emphasize the importance of

Keywords： Guangzhou International Financial City     green eco-urban area     indicator system     case verification    

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Title Author Date Type Operation

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

Journal Article

Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

Journal Article

Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

Journal Article

CONSTRUCTION OF AN INDEX SYSTEM FOR SUSTAINABILITY ASSESSMENT IN SMALLHOLDER FARMING SYSTEMS

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Nonlinear dynamic behavior of rotating blade with breathing crack

Laihao YANG, Zhu MAO, Shuming WU, Xuefeng CHEN, Ruqiang YAN

Journal Article

Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

Journal Article

of the situational awareness effects for smart distribution networks under the novel design of indicator

Leijiao GE, Yuanliang LI, Suxuan LI, Jiebei ZHU, Jun YAN

Journal Article

Marine target detection based on Marine-Faster R-CNN for navigation radar plane position indicator images

Xiaolong CHEN, Xiaoqian MU, Jian GUAN, Ningbo LIU, Wei ZHOU,cxlcxl1209@163.com,guanjian_68@163.com

Journal Article

SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

Journal Article

Smart model for accurate estimation of solar radiation

Lazhar ACHOUR, Malek BOUHARKAT, Ouarda ASSAS, Omar BEHAR

Journal Article

Research on the evaluation creteria of green railway station

Zheng Jian

Journal Article

Application of Hydrogen Peroxide as an Environmental Stress Indicator for Vegetation Management

Takashi Asaeda,Senavirathna Mudalige Don Hiranya Jayasanka,Li-Ping Xia,Abner Barnuevo

Journal Article

The Exploration and Practice of the Development of Green Eco-Urban Areas in Guangzhou International Financial City

Jia-meng Chen,Peng Liu

Journal Article