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Journal Article 1

Year

2015 1

Keywords

Fourier-transform infrared (FTIR) spectroscopy 1

bioreactor cell culture process 1

mouse IgG3 1

partial least squares (PLS) regression 1

process analytical technology (PAT) 1

real time process monitoring 1

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Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy: Implications for enabling cell culture process analytical technology? ?

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 386-406 doi: 10.1007/s11705-015-1533-3

Abstract: Compared to small molecule process analytical technology (PAT) applications, biotechnology product PATprocess is essential to establish an appropriate process control strategy for biotechnology product PATfor real time monitoring of bioreactor cell culture process have the distinct potential to develop PATIts implications for enabling cell culture PAT were discussed.

Keywords： process analytical technology (PAT)     Fourier-transform infrared (FTIR) spectroscopy     partial least squares    

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Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy: Implications for enabling cell culture process analytical technology? ?

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

Journal Article