Search scope:
排序: Display mode:
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 216-226 doi: 10.1007/s11684-022-0920-7
Keywords: tsRNA biomarker hepatocarcinoma
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1, Pages 99-105 doi: 10.1007/s11783-013-0490-7
Keywords: estrogen microRNA (miRNA) microarray biomarker
Plasma transthyretin is a nutritional biomarker in human morbidities
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 540-550 doi: 10.1007/s11684-022-0940-3
Keywords: lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 157-175 doi: 10.1007/s11684-021-0884-z
Keywords: biosensor exosome cancer diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 169-177 doi: 10.1007/s11684-017-0505-z
Keywords: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 723-735 doi: 10.1007/s11684-021-0905-y
Keywords: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 278-285 doi: 10.1007/s11684-016-0453-z
Keywords: iTRAQ secretome colorectal cancer TPM2
Sepsis biomarkers: an omics perspective
Xiao Liu, Hui Ren, Daizhi Peng
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 58-67 doi: 10.1007/s11684-014-0318-2
Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
Keywords: sepsis biomarker genomics transcriptomics proteomics metabolomics
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0880-8
Keywords: miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading public health challenges in China. Over the last two decades, China has made great progress on the prevention of HBV transmission through national vaccination programs. Zero transmission from mother to infant has been proposed as the current goal. Available anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitis B and even requires lifelong treatment. To reduce the costs and improve the efficacy, several trials have been recently conducted in China to optimize the current anti-HBV managements. Novel biomarkers were identified to predict treatment outcomes, and new promising treatment strategies were developed. Reports also indicate that coinfections of HBV with other hepatotropic viruses and human immunodeficiency virus are common in China and cause severe liver diseases, which should be recognized early and treated properly. Work is still needed to eliminate hepatitis B in China by 2030.
Keywords: HBV CHB biomarker functional cure coinfection
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 909-918 doi: 10.1007/s11684-021-0890-1
Keywords: acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker
Yi Cao
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 261-274 doi: 10.1007/s11684-015-0406-y
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
Keywords: environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
Gut microbiota and its implications in small bowel transplantation
Chenyang Wang, Qiurong Li, Jieshou Li
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 239-248 doi: 10.1007/s11684-018-0617-0
The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.
Keywords: gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker
Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
Keywords: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Title Author Date Type Operation
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
Journal Article
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Journal Article
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker
Journal Article
iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Journal Article
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
Journal Article
study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker
Journal Article
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Journal Article
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia
Journal Article
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
Yi Cao
Journal Article
Gut microbiota and its implications in small bowel transplantation
Chenyang Wang, Qiurong Li, Jieshou Li
Journal Article