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2012 1

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LC/MS/MS 1

OCT2 1

catalpol 1

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LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter

Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 436-442 doi: 10.1007/s11705-012-1222-4

Abstract: tandem mass spectrometry (LC/MS/MS) combined with radioisotope method was used for the quantification of catalpolCatalpol uptake experiment was carried out by using several transporters (OAT1, OCT2, OAT3, OATP1B1 andThe results show that catalpol has a good affinity with OCT2-transfected S2 cells.After studying drug-drug interaction between catalpol and C-tetraethylammonium (TEA), we found thatcatalpol is able to facilitate TEA transport mediated by OCT2, suggesting that catalpol could probably

Keywords： catalpol     LC/MS/MS     OCT2    

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LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter

Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI

Journal Article