微生物组分析技术的发展趋势：从单细胞功能成像到菌群大数据

工程（英文） ›› 2017, Vol. 3 ›› Issue (1) : 66-70.

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工程（英文） ›› 2017, Vol. 3 ›› Issue (1) : 66-70. DOI: 10.1016/J.ENG.2017.01.020
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微生物组分析技术的发展趋势：从单细胞功能成像到菌群大数据

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Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data

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Abstract

Method development has always been and will continue to be a core driving force of microbiome science. In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift from dissecting microbiota structureby sequencing to tracking microbiota state, function, and intercellular interaction via imaging; ② a shift from interrogating a consortium or population of cells to probing individual cells; and ③ a shift from microbiome data analysis to microbiome data science. Some of the recent method-development efforts by Chinese microbiome scientists and their international collaborators that underlie these technological trends are highlighted here. It is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding “Made-in-China” tools to the international research community, by building an ambitious, competitive, and collaborative program at the forefront of method development for microbiome science.

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Microbiome / Methoddevelopment / Single-cell analysis / Big data / China Microbiome Initiative

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. . Engineering. 2017, 3(1): 66-70 https://doi.org/10.1016/J.ENG.2017.01.020

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Acknowledgements

We are grateful to the support from the National Natural Science Foundation of China (NSFC) (31425002, 91231205, 81430011, 61303161, 31470220, and 31327001), and the Frontier Science Research Program, the Soil-microbe System Function and Regulation Program, and the Science and Technology Service Network Initiative (STS) from the Chinese Academy of Sciences (CAS).

Compliance with ethics guidelines

Jian Xu, Bo Ma, Xiaoquan Su, Shi Huang, Xin Xu, Xuedong Zhou, Wei Huang, and Rob Knight declare that they have no conflict of interest or financial conflicts to disclose.

版权

2017 2017 THE AUTHORS. Published by Elsevier LTD on behalf of the Chinese Academy of Engineering and Higher Education Press Limited Company. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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