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发生于胃和结直肠的印戒细胞癌的临床特征以及不同部位的转移对预后的预测价值的研究
Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li
工程（英文） ›› 2020, Vol. 6 ›› Issue (9) : 1028-1034.
PDF(1013 KB)
PDF(1013 KB)
发生于胃和结直肠的印戒细胞癌的临床特征以及不同部位的转移对预后的预测价值的研究
Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Ring Cell Carcinoma
印戒细胞癌是胃、结直肠肿瘤中恶性程度最高的病理类型之一。本研究分析了印戒细胞癌的转移特性及其对肿瘤特异性生存率的影响。这项研究纳入了4055例在2010—2012年被诊断为胃印戒细胞癌（signet ring cell carcinoma, SRCC）、结直肠印戒细胞癌患者，其中胃印戒细胞癌2905例，结肠印戒细胞癌和直肠印戒细胞癌1150例。所有临床数据来源于癌症监测、流行病学、最终结果登记资料数据库（SEER）。我们通过卡方检验分析在确诊时伴有远处转移的患者及无远处转移的患者的临床特征。同时用Kaplan-Meier、Cox风险比例回归模型分析出现不同部位转移的患者的预后差异。研究发现，在胃印戒细胞癌患者中，远处淋巴结转移是其最常见的转移部位，而出现脑转移的患者其预后最差。而在患有结肠或直肠的印戒细胞癌患者中，肝脏是其最常见的转移部位，而在确诊时出现远处淋巴结转移的患者的拥有最高的死亡率。总之，出现远处转移常常是预后较差的标志之一，我们的研究结果为印戒细胞癌患者的临床随访、预后分析提供一定的建议。
Gastric signet ring cell carcinoma (SRCC) and colorectal SRCC are the most aggressive histological types of carcinoma related to a poor prognosis, and place a heavy burden on public health. We undertook a population-based study to analyze the metastatic patterns of SRCC and further estimate its contribution to the cancer-specific survival of gastric SRCC and colorectal SRCC. Data from eligible patients diagnosed with gastric or colorectal SRCC between 2010 and 2012 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Chi-squared tests were used to clarify the clinical features in patients with metastatic disease compared with those without metastatic disease. Survival differences of patients with different metastatic sites were compared with a Kaplan–Meier analysis, and other prognostic factors were examined by Cox proportional hazards models. A total of 4055 patients with gastric SRCC or colorectal SRCC were included in our cohort. Among them, 2905 were diagnosed with gastric SRCC, and the remaining 1150 patients were diagnosed with colorectal SRCC. In gastric SRCC, distant lymph nodes were the most common metastatic sites. Furthermore, patients with brain metastases had the worst prognosis. In colorectal SRCC, the liver was the most common metastatic site, and patients with distant lymph node metastases had the highest mortality. In summary, metastasis is a major contributor to cancer mortality in SRCC. The results from our study provide some information for developing follow-up strategies in future studies.
SEER数据库，生存分析，印戒细胞癌，转移，结直肠癌，胃癌 /
SEER Program / Survival analysis / Signet ring cell carcinoma / Metastases / Colorectal cancer / Gastric cancer
| [1] |
Chen J, Cai R, Ren G, Zhao J, Li H, Guo C, et al. Differences in clinicopathological characteristics and computed tomography findings between signet ring cell carcinoma and nonsignet ring cell carcinoma in early and advanced gastric cancer. Cancer Med 2018;7(4):1160–9.
|
| [2] |
Barresi V, Reggiani BL, Domati F, Baron L. Prognostic relevance of histopathological features in signet ring cell carcinoma of the colorectum. Virchows Arch 2016;469(3):267–75.
|
| [3] |
Huang B, Ni M, Chen C, Feng Y, Cai S. Younger age is associated with poorer survival in patients with signet-ring cell carcinoma of the colon without distant metastasis. Gastroenterol Res Pract 2016;2016:2913493.
|
| [4] |
Liang Z, Yan D, Li G, Cheng H. Clinical analysis of primary colorectal signet-ring cell carcinoma. Clin Colorectal Cancer 2018;17(1):e39–44.
|
| [5] |
Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, et al. Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis. Expert Rev Gastroenterol Hepatol 2018;12(2):209–14.
|
| [6] |
Nie RC, Yuan SQ, Li YF, Chen YM, Chen XJ, Zhu BY, et al. Clinicopathological characteristics and prognostic value of signet ring cells in gastric carcinoma: a meta-analysis. J Cancer 2017;8(17):3396–404.
|
| [7] |
Kermanshahi TR, Magge D, Choudry H, Ramalingam L, Zhu B, Pingpank J, et al. Mucinous and signet ring cell differentiation affect patterns of metastasis in colorectal carcinoma and influence survival. Int J Surg Pathol. 2017;25 (2):108–17.
|
| [8] |
SEER*Stat databases. Bethesda: National Cancer Institute; [cited 2018 May 5]. Available from: https://seer.cancer.gov/data-software/documentation/seerstat/.
|
| [9] |
Wu W, Fang D, Shi D, Bian X, Li L. Effects of marital status on survival of hepatocellular carcinoma by race/ethnicity and gender. Cancer Manag Res 2018;10:23–32.
|
| [10] |
Soneji S, Tanner NT, Silvestri GA, Lathan CS, Black W. Racial and ethnic disparities in early-stage lung cancer survival. Chest 2017;152(3):587–97.
|
| [11] |
Yang Y, Wang G, He J, Ren S, Wu F, Zhang J, et al. Gender differences in colorectal cancer survival: a meta-analysis. Int J Cancer 2017;141(10):1942–9.
|
| [12] |
Tajiri K, Sudou T, Fujita F, Hisaka T, Kinugasa T, Akagi Y. Clinicopathological and corresponding genetic features of colorectal signet ring cell carcinoma. Anticancer Res 2017;37(7):3817–23.
|
| [13] |
Psathakis D, Schiedeck TH, Krug F, Oevermann E, Kujath P, Bruch HP. Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage. Dis Colon Rectum 1999;42 (12):1618–25.
|
| [14] |
Imamura T, Komatsu S, Ichikawa D, Kawaguchi T, Kosuga T, Okamoto K, et al. Early signet ring cell carcinoma of the stomach is related to favorable prognosis and low incidence of lymph node metastasis. J Surg Oncol 2016;114 (5):607–12.
|
| [15] |
Pokala SK, Zhang C, Chen Z, Gamboa AM, Cristofaro SL, Keilin SA, et al. Incidence, survival, and predictors of lymph node involvement in early-stage gastric signet ring cell carcinoma in the US. J Gastrointest Surg 2018;22 (4):569–77.
|
| [16] |
Ling CR, Wang R, Wang MJ, Ping J, Zhuang W. Prognosis and value of preoperative radiotherapy in locally advanced rectal signet-ring cell carcinoma. Sci Rep 2017;7(1):45334.
|
| [17] |
Ogino S, Brahmandam M, Cantor M, Namgyal C, Kawasaki T, Kirkner G, et al. Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. Mod Pathol 2006;19(1):59–68.
|
| [18] |
Wistuba II, Behrens C, Albores-Saavedra J, Delgado R, Lopez F, Gazdar AF. Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma. Clin Cancer Res 2003;9(10 Pt 1):3615–9.
|
| [19] |
Lam AKY, Ong K, Ho YH. Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression. Dis Colon Rectum 2006;49(9):1275–83.
|
| [20] |
Song BR, Xiao CC, Wu ZK. Predictors of lymph node metastasis and prognosis in pT1 colorectal cancer patients with signet-ring cell and mucinous adenocarcinomas. Cell Physiol Biochem 2017;41(5):1753–65.
|
| [21] |
Hugen N, van de Velde CJ, de Wilt JH, Nagtegaal ID. Metastatic pattern in colorectal cancer is strongly influenced by histological subtype. Ann Oncol 2014;25(3):651–7.
|
| [22] |
Bozkaya Y, Erdem GU, Ozdemir NY, Demirci NS, Hocazade C, Yazıcı O, et al. Comparison of clinicopathological and prognostic characteristics in patients with mucinous carcinoma and signet ring cell carcinoma of the stomach. Curr Med Res Opin 2017;33(1):109–16.
|
| [23] |
Börger ME, Gosens MJ, Jeuken JW, van Kempen LC, van de Velde CJ, van Krieken JH, et al. Signet ring cell differentiation in mucinous colorectal carcinoma. J Pathol 2007;212(3):278–86.
|
| [24] |
Guo CG, Zhao DB, Liu Q, Zhou ZX, Zhao P, Wang GQ, et al. Risk factors for lymph node metastasis in early gastric cancer with signet ring cell carcinoma. J Gastrointest Surg 2015;19(11):1958–65.
|
| [25] |
Yang XF, Yang L, Mao XY, Wu DY, Zhang SM, Xin Y. Pathobiological behavior and molecular mechanism of signet ring cell carcinoma and mucinous adenocarcinoma of the stomach: a comparative study. World J Gastroenterol 2004;10(5):750–4.
|
| [26] |
Randi G, Altieri A, Gallus S, Chatenoud L, Montella M, Franceschi S, et al. Marital status and cancer risk in Italy. Prev Med 2004;38(5):523–8.
|
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