生物细胞的旋转——基本原理及应用
Tao Tang , Yoichiroh Hosokawa , Takeshi Hayakawa , Yo Tanaka , Weihua Li , Ming Li , Yaxiaer Yalikun
工程（英文） ›› 2022, Vol. 10 ›› Issue (3) : 110 -126.
生物细胞的旋转——基本原理及应用
Tao Tang , Yoichiroh Hosokawa , Takeshi Hayakawa , Yo Tanaka , Weihua Li , Ming Li , Yaxiaer Yalikun
工程（英文） ›› 2022, Vol. 10 ›› Issue (3) : 110 -126.
生物细胞的旋转——基本原理及应用
Rotation of Biological Cells: Fundamentals and Applications
细胞旋转是现代生物科学中最重要的细胞操作技术之一，不仅允许从任意角度观察细胞，而且还简化了分析细胞力学特性、表征细胞生理学和进行显微手术的程序。在广泛的学术和工业应用中，已经报道了许多细胞旋转的方法。其中，最受欢迎的是基于微型机器人的直接接触控制和基于场的非接触方法（如光场、磁场、电场、声场和流体动力场方法）。本文首先总结了这六大类方法的基本机制、优点和缺点，然后详细讨论了它们的区别和局限性。本文旨在缩短每种方法之间的差距，并说明细胞旋转领域目前的研究进展及未来前景。
Cell rotation is one of the most important techniques for cell manipulation in modern bioscience, as it not only permits cell observation from any arbitrary angle, but also simplifies the procedures for analyzing the mechanical properties of cells, characterizing cell physiology, and performing microsurgery. Numerous approaches have been reported for rotating cells in a wide range of academic and industrial applications. Among them, the most popular are micro-robot-based direct contact manipulation and field-based non-contact methods (e.g., optical, magnetic, electric, acoustic, and hydrodynamic methods). This review first summarizes the fundamental mechanisms, merits, and demerits of these six main groups of approaches, and then discusses their differences and limitations in detail. We aim to bridge the gap between each method and illustrate the development progress, current advances, and prospects in the field of cell rotation.
Cell rotation / Cell reorientation / Micromanipulation / Microfluidics
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