城市化、人口增长以及食物-能源-水（food-energy-water, FEW）的加速消耗给经济、环境和社会（economic, environmental, and social, ESS）的可持续性发展带来了前所未有的挑战。当今世界正加速从自然生态系统向管理生态系统过渡，因此了解FEW 系统对实现联合国可持续发展目标（sustainable development goal, SDG）的潜在影响很有必要。由于FEW系统及相关网络具备复杂性和新兴行为，人们无法通过单一学科研究对其做出全面理解或有效预测，这是现存的主要障碍。本文提出了一个组织化研究框架，推动自上而下、跨学科地量化FEW系统和ESS系统间的相互关系。相关方法包括改善跨部门、跨尺度的协调互动，扩展和多样化供应链网络，革新技术促进资源的有效利用。这一框架可以指导战略解决方案的制定，削弱地区或国家内部不同部门对FEW资源的竞争，并在实施可持续发展议程时最大限度减少FEW资源及其可用性分配不平等的现象。

Urbanization, population growth, and the accelerating consumption of food, energy, and water (FEW) resources bring unprecedented challenges for economic, environmental, and social (EES) sustainability. It is imperative to understand the potential impacts of FEW systems on the realization of the United Nation's Sustainable Development Goals (SDGs) as the world transitions from natural ecosystems to managed ecosystems at an accelerating rate. A major obstacle is the complexity and emergent behavior of FEW systems and associated networks, for which no single discipline can generate a holistic understanding or meaningful projections. We propose a research enterprise framework for promoting transdisciplinarity and top-down quantification of the interrelationships between FEW and EES systems. Relevant enterprise efforts would emphasize increasing FEW resource accessibility by improving coordinated interplays across sectors and scales, expanding and diversifying supply-chain networks, and innovating technologies for efficient resource utilization. This framework can guide the development of strategic solutions for diminishing the competition among FEW-consuming sectors in a region or country, and for minimizing existing inequalities in FEW availability when a sustainable development agenda is implemented.