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表面"彩虹"上的超分辨率光谱位移传感
Lyu Zhou, Nan Zhang, Chang Chieh Hsu, Matthew Singer, Xie Zeng, Yizheng Li, Haomin Song, Josep Jornet, Yun Wu, Qiaoqiang Gan
工程（英文） ›› 2022, Vol. 17 ›› Issue (10) : 75-81.
PDF(2204 KB)
PDF(2204 KB)
表面"彩虹"上的超分辨率光谱位移传感
Super-Resolution Displacement Spectroscopic Sensing over a Surface “Rainbow”
高精度的亚波长光波操纵在光谱学、传感和医学成像中可实现令人兴奋的新颖应用。这些应用中理想的目标是可实现光谱信息片上分析的小型化光谱仪。特别地，对于基于成像系统的光谱传感机制，其关键挑战是如何实现精准的空间信息分辨（即波长偏移或生物、化学表面结合引起的空间位移），这类似于超分辨率成像所带来的挑战。本文中，我们报道了一种特殊的可以捕获“彩虹”的超表面，并将其应用于芯片光谱仪和传感器。结合超分辨图像处理，通过低设置4×光学显微镜系统可分辨出等离子体“彩虹”捕获超表面上35 nm范围内共振位置的位移，同时该超表面的面积小至0.002 mm2。这种可实现高效耦合的“彩虹”等离子体共振空间操纵的独特特征为小型化片上光谱分析提供了一个新的平台，其光谱分辨率为0.032 nm波长偏移。通过使用该低设置4×光学显微镜成像系统，我们展示了A549 外泌体的生物传感分辨率为1.92×109个∙mL−1，并使用外泌体表皮生长因子受体（EGFR）的表达值来区分患者样本和健康对照样本，从而展示了一种精确特异性生物/化学传感检测应用的新型片上传感系统。
Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy, sensing, and medical imaging. For these applications, miniaturized spectrometers are desirable to enable the on-chip analysis of spectral information. In particular, for imaging-based spectroscopic sensing mechanisms, the key challenge is to determine the spatial-shift information accurately (i.e., the spatial displacement introduced by wavelength shift or biological or chemical surface binding), which is similar to the challenge presented by super-resolution imaging. Here, we report a unique “rainbow” trapping metasurface for on-chip spectrometers and sensors. Combined with super-resolution image processing, the low-setting 4× optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as 0.002 mm2. This unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength shift. Using this low-setting 4× microscope imaging system, we demonstrate a biosensing resolution of 1.92 × 109 exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor (EGFR) expression values, thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.
“彩虹”捕获 / 超表面 / 表面等离子体激元 / 超分辨位移 / 片上生物传感
Rainbow trapping / Metasurface / Surface plasmon polaritons / Super-resolution displacement / On-chip biosensing
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