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基于脱细胞后鱼皮细胞外基质的生物打印水凝胶纺织品用于创面修复
Xiang Lin, Han Zhang, Hui Zhang, Zhuohao Zhang, Guopu Chen, Yuanjin Zhao
工程（英文） ›› 2023, Vol. 25 ›› Issue (6) : 120-127.
PDF(2737 KB)
PDF(2737 KB)
基于脱细胞后鱼皮细胞外基质的生物打印水凝胶纺织品用于创面修复
Bio-Printed Hydrogel Textiles Based on Fish Skin Decellularized Extracellular Matrix for Wound Healing
常见的创面修复具有治疗难度大、患者数量多、医疗负担重等特点，一直是临床研究的热点。研究者投入了大量的科研力量来生产各种具有定制需求和功能的伤口敷料。这里，我们提出了基于鱼皮脱细胞的细胞外基质（dECM）水凝胶纺织品用于创面修复。鱼源dECM具有理想的生物相容性，所以生物打印纺织品在细胞黏附和增殖方面表现出优异的性能。此外，基于dECM的水凝胶是使用生物打印方法生成的，因此其表面呈现出可调节的多孔结构，整个纺织品具有良好的透气性。而且，水凝胶骨架上多孔结构中的高比表面积使其能够负载多种活性分子，提高伤口愈合效果。根据体内研究结果，我们证明制备的纺织品在负载活性药物分子姜黄素（Cur）和碱性成纤维细胞生长因子（bFGF）后，可以加速慢性创面修复过程。这些结果表明鱼皮dECM纺织品在创面修复和生物医学工程中具有潜在价值。
Wound healing has always been a focus of clinical study due to its universality, difficult treatment, large number of patients, and heavy medical burden. A great deal of effort has been devoted to generating various wound dressings with special features and functions to satisfy specific demands. Here, we present novel bio-printed textiles based on fish skin decellularized extracellular matrix (dECM) for wound healing. Thanks to the desirable biocompatibility of the fish-derived dECM, the bio-printed textiles exhibit excellent performance in terms of cell adherence and proliferation. Since the dECM-based hydrogels are generated using a bio-printing method, the bio-printed textiles exhibit an adjustable porous structure with good air permeability throughout the whole textile. Moreover, the high specific surface areas of the porous structure on the hydrogel skeleton make it possible to load a variety of active molecules to improve the wound healing effect. According to an in vivo study, we demonstrate that the prepared textiles loaded with the active drug molecules curcumin (Cur) and basic fibroblast growth factor (bFGF) can significantly speed up the chronic wound healing process. These remarkable properties indicate the potential value of fish-skin-dECM textiles in wound healing and biomedical engineering.
生物打印 / 鱼皮 / 细胞外基质 / 水凝胶 / 创面修复
Bio-printing / Fish skin / Decellularized extracellular matrix / Hydrogel / Wound healing
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