人前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖

Engineering ›› 2023, Vol. 26 ›› Issue (7) : 119 -131. DOI: 10.1016/j.eng.2023.02.009

研究论文

Wei Wang ^a ,
Tao Zhang ^a ,
Jan Nouta ^a ,
Peter A. van Veelen ^a ,
Noortje de Haan ^a^,^b ,
Theo M. de Reijke ^c ,
Manfred Wuhrer ^a ,
Guinevere S.M. Lageveen-Kammeijer ^a^,^d

作者信息 +

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid

Wei Wang ^a ,
Tao Zhang ^a ,
Jan Nouta ^a ,
Peter A. van Veelen ^a ,
Noortje de Haan ^a^,^b ,
Theo M. de Reijke ^c ,
Manfred Wuhrer ^a ,
Guinevere S.M. Lageveen-Kammeijer ^a^,^d

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文章历史 +

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Abstract

Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals. However, associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer progression. Hitherto, there has been a lack of conclusive evidence that Kdn occurs on (specific) human glycoproteins (conjugated Kdn). Here, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N-linked glycans derived from human seminal plasma and urine. Interestingly, Kdn was found only in an α2,3-linkage configuration on an antennary galactose, indicating a highly specific biosynthesis. This unusual glycosylation feature was also identified in a urinary PSA cohort in relation to prostate cancer (PCa), although no differences were found between PCa and non-PCa patients. Further research is needed to investigate the occurrence, biosynthesis, biological role, and biomarker potential of both free and conjugated Kdn in humans.

关键词

酮基-脱氧壬酮糖酸 / 糖基化 / 前列腺癌 / 前列腺特异性抗原

Key words

Ketodeoxynononic acid / Kdn / Glycosylation / Prostate cancer / Prostate-specific antigen

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Wei Wang,Tao Zhang,Jan Nouta,Peter A. van Veelen,Noortje de Haan,Theo M. de Reijke,Manfred Wuhrer,Guinevere S.M. Lageveen-Kammeijer. 人前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖[J]. 工程（英文）, 2023, 26(7): 119-131 DOI:10.1016/j.eng.2023.02.009