中国上海某大型方舱医院新型冠状病毒气溶胶时空分布研究

工程（英文）

Adv search

中国上海某大型方舱医院新型冠状病毒气溶胶时空分布研究

江佳富 , 殷喆 , 李靖 , 贾雷利 , 和儒林 , 杨文慧 , 杨佶虎 , 范航 , 张森 , 王云飞 , 赵增明 , 彭浩然 , 李利忠 , 杨益 , 樊士勇 , 相蓉 , 郭建树 , 王金金 , 魏娟 , 周凤玲 , 刘丁 , 赵平 , 崔玉军 , 刘运喜 , 周冬生 , 董罡

Engineering ›› 2023, Vol. 28 ›› Issue (9) : 222 -233.

PDF (2368KB)

Engineering ›› 2023, Vol. 28 ›› Issue (9) : 222 -233. DOI: 10.1016/j.eng.2023.06.006

研究论文

中国上海某大型方舱医院新型冠状病毒气溶胶时空分布研究

江佳富 ^a ,
殷喆 ^a ,
李靖 ^a ,
贾雷利 ^b ,
和儒林 ^d ,
杨文慧 ^a ,
杨佶虎 ^a ,
范航 ^a ,
张森 ^a ,
王云飞 ^a ,
赵增明 ^b ,
彭浩然 ⁱ ,
李利忠 ^b ,
杨益 ^b ,
樊士勇 ,
相蓉 ^a ,
郭建树 ^a ,
王金金 ^e ,
魏娟 ^f ,
周凤玲 ^g ,
刘丁 ^h ,
赵平 ⁱ ,
崔玉军 ^a ,
刘运喜 ^c^,^* ,
周冬生 ^a^,^* ,
董罡 ^a^,^*

作者信息 +

^aBeijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China

^bChinese People’s Liberation Army Center for Disease Control and Prevention, Beijing 100071, China

^cDepartment of Disease Prevention and Control, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

^dThe 902 Hospital of People’s Liberation Army Joint Logistics Support Force, Bengbu 233015, China

^eGeneral Hospital of Eastern Theater Command, People’s Liberation Army, Nanjing 210002, China

^fFourth Military Medical University, Xijing Hospital, Xi’an 710032, China

^gGeneral Hospital of Central Theater Command of Chinese People’s Liberation Army, Wuhan 430070, China

^hThird Military Medical University, Southwest Hospital, Chongqing 400038, China

ⁱDepartment of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China

^jAcademy of Military Medical Sciences Institute of Pharmacology and Toxicology, Beijing 100039, China

收起

Temporal and Spatial Distribution of SARS-CoV-2 Aerosols in a Large-Scale Fangcang Shelter Hospital in Shanghai, China

Jiafu Jiang ^a^,^# ,
Zhe Yin ^a^,^# ,
Jing Li ^a^,^# ,
Leili Jia ^b^,^# ,
Rulin He ^d^,^# ,
Wenhui Yang ^a^,^# ,
Jihu Yang ^a ,
Hang Fan ^a ,
Sen Zhang ^a ,
Yunfei Wang ^a ,
Zengming Zhao ^b ,
Haoran Peng ⁱ ,
Lizhong Li ^b ,
Yi Yang ^b ,
Shi-Yong Fan ,
Rong Xiang ^a ,
Jianshu Guo ^a ,
Jinjin Wang ^e ,
Juanning Wei ^f ,
Fengling Zhou ^g ,
Ding Liu ^h ,
Ping Zhao ⁱ ,
Yujun Cui ^a ,
Yunxi Liu ^c^,^* ,
Dongsheng Zhou ^a^,^* ,
Gang Dong ^a^,^*

Author information +

^aBeijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China

^bChinese People’s Liberation Army Center for Disease Control and Prevention, Beijing 100071, China

^cDepartment of Disease Prevention and Control, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

^dThe 902 Hospital of People’s Liberation Army Joint Logistics Support Force, Bengbu 233015, China

^eGeneral Hospital of Eastern Theater Command, People’s Liberation Army, Nanjing 210002, China

^fFourth Military Medical University, Xijing Hospital, Xi’an 710032, China

^gGeneral Hospital of Central Theater Command of Chinese People’s Liberation Army, Wuhan 430070, China

^hThird Military Medical University, Southwest Hospital, Chongqing 400038, China

ⁱDepartment of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China

^jAcademy of Military Medical Sciences Institute of Pharmacology and Toxicology, Beijing 100039, China

* E-mail addresses: liuyunxi301@qq.com (Y. Liu),

zhouds@bmi.ac.cn (D. Zhou),

donggang@bmi.ac.cn (G. Dong).

Show less

文章历史 +

PDF (2424K)

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by frequently mutating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a worldwide impact. However, detailed data on the potential aerosol transmission of SARS-CoV-2 in real-world and controlled laboratory settings remain sparse. During the COVID-19 pandemic in Shanghai, China in 2022, samples were collected in a Fangcang shelter hospital, a large-scale temporary hospital rapidly built by converting the existing National Exhibition and Convention Center (Shanghai) into a health care facility. Aerosol samples at different sites and intervals around patients and in public areas, surface samples, and pharyngeal swab samples from corresponding patients were included. Samples were tested for SARS-CoV-2 using real-time quantitative polymerase chain reaction (RT-qPCR) assays, followed by sequencing if the cycle threshold (Ct) value was < 30. The positivity rate for SARS-CoV-2 in aerosol samples was high in contaminated zones (37.5%, 104/277), especially around the bed (41.2%, 68/165) and near ventilation inlets (45.2%, 14/31). The prevalence of SARS-CoV-2 around the bed, public areas, and air inlets of exhaust vents fluctuated and was closely related to the positivity rate among patients at corresponding sampling sites. Some surface samples of different personal protective equipment from medical staff had high positivity rates. Sixty sequences of joined ORF1ab and spike genes obtained from sixty samples represented two main clusters of Omicron SARS-CoV-2. There was consistency in virus sequences from the same patient and their environment, and the detected virus sequences matched those of virus strains in circulation during the collection periods, which indicated a high likelihood of cross-contamination in the Fangcang shelter hospital. In summary, the results provide a quantitative and real landscape of the aerosol transmission of SARS-CoV-2 and a patient-centered view of contamination in large and enclosed spaces and offer a useful guide for taking targeted measures to avoid nosocomial infections during the management of SARS-CoV-2 or other respiratory virus diseases in a Fangcang shelter hospital.

关键词

新型冠状病毒肺炎 / 严重急性呼吸综合征冠状病毒2 / 气溶胶 / 方舱医院 / 中国

Key words

Coronavirus disease 2019 / Severe acute respiratory syndrome coronavirus 2 / Aerosols / Fangcang shelter hospital / China

引用本文

引用格式 ▾

江佳富,殷喆,李靖,贾雷利,和儒林,杨文慧,杨佶虎,范航,张森,王云飞,赵增明,彭浩然,李利忠,杨益,樊士勇,相蓉,郭建树,王金金,魏娟,周凤玲,刘丁,赵平,崔玉军,刘运喜,周冬生,董罡. 中国上海某大型方舱医院新型冠状病毒气溶胶时空分布研究[J]. 工程（英文）, 2023, 28(9): 222-233 DOI:10.1016/j.eng.2023.06.006

登录浏览全文

4963

注册一个新账户忘记密码

参考文献

原文顺序 | 出版日期 | 本文引用

AI Summary AI Mindmap

PDF (2368KB)

专题

Supplementary files

Supplementary Material

1534

访问

0

被引

Altmetric

详细

导航

相关文章

/

〈

〉