CGMP联合体——一项通过多组学和精准微生态法干预便秘的多中心纵向临床试验计划

Linlin Wang, Tong Zhang, Hongliang Tian, Qiyi Chen, Lianmin Chen, Yuzheng Xue, Gaojue Wu, Yurong Tang, Ning Li, Qixiao Zhai, Wei Chen

工程(英文) ›› 2024, Vol. 43 ›› Issue (12) : 17-21.

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工程(英文) ›› 2024, Vol. 43 ›› Issue (12) : 17-21. DOI: 10.1016/j.eng.2024.11.011
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CGMP联合体——一项通过多组学和精准微生态法干预便秘的多中心纵向临床试验计划

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CGMP Consortium: A Multicenter, Longitudinal Clinical Trial Plan for Constipation Multi-Omics and Precision Micro-Ecological Intervention Strategies

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Abstract

Highlights

• Prospective multi-omics, multicenter, longitudinal clinical trial protocol CGMP top-level design.

• The CGMP cohort will serve as a unique resource for studying the etiology of constipation and diagnosing constipation based on gut microbiota.

• The CGMP cohort study will help develop microbiota-targeted dietary or clinical therapies for various types of constipation.

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Linlin Wang, Tong Zhang, Hongliang Tian. CGMP联合体——一项通过多组学和精准微生态法干预便秘的多中心纵向临床试验计划. Engineering. 2024, 43(12): 17-21 https://doi.org/10.1016/j.eng.2024.11.011

参考文献

[1]
Z. Chen, Y. Peng, Q. Shi, Y. Chen, L. Cao, J. Jia, et al. Prevalence and risk factors of functional constipation according to the rome criteria in china: a systematic review and meta-analysis. Fron Med, 9 (2022), Article 815156.
[2]
A.I. Kaplan, Y. Mazor, G.M. Prott, C. Sequeira, M.P. Jones, A. Malcolm. Experiencing multiple concurrent functional gastrointestinal disorders is associated with greater symptom severity and worse quality of life in chronic constipation and defecation disorders. Neurogastroent Motil, 35 (4) (2023), Article e14524.
[3]
L.A. Harris, C.H. Chang. Burden of constipation: looking beyond bowel movements. Am J Gastroenterol, 117 (4s) (2022), pp. S2-S5.
[4]
A. Van Der Schoot, Z. Katsirma, K. Whelan, E. Dimidi. Systematic review and meta-analysis: foods, drinks and diets and their effect on chronic constipation in adults. Aliment Pharm Ther, 59 (2) (2024), pp. 157-174.
[5]
H. Nakagawa, H. Sasai, Y. Kato, S. Matsumoto, K. Tanaka. Exercise, dietary habits, and defecatory dysfunction in patients living with colorectal cancer: a preliminary quantitative study. Healthcare, 12 (11) (2024), p. 1136.
[6]
H.B. Murray, R. Flanagan, B. Banashefski, C.J. Silvernale, B. Kuo, K. Staller. Frequency of eating disorder pathology among patients with chronic constipation and contribution of gastrointestinal-specific anxiety. Clin gastroenterol H, 18 (11) (2020), pp. 2471-2478.
[7]
G. Parthasarathy, J. Chen, X. Chen, N. Chia, H.M. O’Connor, P.G. Wolf, et al. Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation. Gastroenterology, 150 (2) (2016), pp. 367-379.
[8]
J. Wang, L. Wang, Q. Yu, N. Tang, C. Mei, H. Zhang, et al. Characteristics of the gut microbiome and serum metabolome in patients with functional constipation. Nutrients, 15 (7) (2023), p. 1779.
[9]
X. Chen, T.T. Qiu, Y. Wang, L.Y. Xu, J. Sun, Z.H. Jiang, et al. A Shigella species variant is causally linked to intractable functional constipation. J Clin Invest, 152 (S3) (2023), p. S61.
[10]
H. Cao, X. Liu, Y. An, G. Zhou, Y. Liu, M. Xu, et al. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Sci Rep, 7 (1) (2017), p. 10322.
[11]
R. Fu, Z. Li, R. Zhou, C. Li, S. Shao, J. Li. The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation. Bioengineered, 12 (1) (2021), pp. 6484-6498.
[12]
D.A. Drossman. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology, 150 (6) (2016), pp. 1262-1279.
[13]
F. Agachan, T. Chen, J. Pfeifer, P. Reissman, S.D. Wexner. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum, 39 (6) (1996), pp. 681-685.
[14]
S.C. McMillan, F.A. Williams. Validity and reliability of the constipation assessment scale. Cancer Nurs, 12 (3) (1989), pp. 183-188.
[15]
L. Frank, L. Kleinman, C. Farup, L. Taylor, P.J. Miner. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroentero, 34 (9) (1999), pp. 870-877.
[16]
M.G. Varma, J.Y. Wang, J.R. Berian, T.R. Patterson, G.L. McCrea, S.L. Hart. The constipation severity instrument: a validated measure. Dis Colon Rectum, 51 (2) (2008), pp. 162-172.
[17]
P. Marquis, C. De La Loge, D. Dubois, A. McDermott, O. Chassany. Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroentero, 40 (5) (2005), pp. 540-551.
[18]
D.F. Altomare, L. Spazzafumo, M. Rinaldi, G. Dodi, R. Ghiselli, V. Piloni. Set-up and statistical validation of a new scoring system for obstructed defaecation syndrome. Colorectal Dis, 10 (1) (2008), pp. 84-88.
[19]
W. Sun, Y. Wang, H. Zhang, Y. Sheng, J. Fan, M. Gu, et al. Ehypertension: a prospective longitudinal multi-omics essential hypertension cohort. iMeta, 1 (2) (2022), p. e22.
[20]
A. Satija, S.N. Bhupathiraju, D. Spiegelman, S.E. Chiuve, J.E. Manson, W. Willett, et al. Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults. J Am Coll Cardiol, 70 (4) (2017), pp. 411-422.
[21]
C. Bycroft, C. Freeman, D. Petkova, G. Band, L.T. Elliott, K. Sharp, et al. The UK biobank resource with deep phenotyping and genomic data. Nature, 562 (7726) (2018), pp. 203-209.
[22]
C. Zhang, L. Yu, C. Ma, S. Jiang, Y. Zhang, S. Wang, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe, 31 (12) (2023), pp. 1989-2006.
[23]
Q. Fang, L. Yu, F. Tian, W. Chen, Q. Zhai. Understanding of the efficacy of gut microbiota-directed foods on human health. Trends Food Sci Tech (2023), pp. 13692-13699.
[24]
J.M. Green, M.J. Barratt, M. Kinch, J.I. Gordon. Food and microbiota in the FDA regulatory framework. Science, 357 (6346) (2017), pp. 39-40.
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