脊髓损伤修复的前沿交叉研究——工程驱动的机制探索与临床转化新范式

Mi Zhou; Xue Yao; Boya Huang; Jie Ren; Haiwen Feng; Shiqing Feng

doi:10.1016/j.eng.2025.11.012

工程（英文） ›› 2026, Vol. 60 ›› Issue (5) : 310 -335. DOI: 10.1016/j.eng.2025.11.012

研究论文

脊髓损伤修复的前沿交叉研究——工程驱动的机制探索与临床转化新范式

Mi Zhou ^a^,^# ,
Xue Yao ^a^,^# ,
Boya Huang ^a ,
Jie Ren ^a ,
Haiwen Feng ^a ,
Shiqing Feng ^a^,^b^,^c^,^*

作者信息 +

Frontier Integration in Spinal Cord Injury Repair: Engineering-Driven Mechanistic Exploration and a New Paradigm for Clinical Translation

Mi Zhou ^a^,^# ,
Xue Yao ^a^,^# ,
Boya Huang ^a ,
Jie Ren ^a ,
Haiwen Feng ^a ,
Shiqing Feng ^a^,^b^,^c^,^*

Author information +

文章历史 +

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Abstract

Spinal cord injury (SCI) is a devastating traumatic disorder of the central nervous system that severely impairs sensory, motor, and autonomic functions, placing heavy burdens on patients, families, and society. This review summarizes engineering advances in SCI repair, emphasizing neuromodulation therapies, surgical approaches, cell therapy, pharmacological and gene therapies, and biomaterial-based tissue engineering. It also discusses challenges in clinical translation, such as ethical considerations, multimodal technology integration, and interindividual variability. The review underscores the importance of strengthening interdisciplinary collaboration to integrate multiple-model treatments and accelerate their clinical application.

关键词

Key words

Spinal cord injury / Tissue engineering / Neuromodulation / Biomaterial / Brain-computer interface / Translational medicine

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Mi Zhou,Xue Yao,Boya Huang,Jie Ren,Haiwen Feng,Shiqing Feng. 脊髓损伤修复的前沿交叉研究——工程驱动的机制探索与临床转化新范式[J]. 工程（英文）, 2026, 60(5): 310-335 DOI:10.1016/j.eng.2025.11.012