肺癌中异常磷脂代谢是启动恶性转化、增强细胞存活的开关

Wei-Qian Bao; Tian-Tian Xu; Bi-Qing Huang; Shu-Qin Li; Meng-Lin Jiang; Gang-Yuan Ma; Cui-Fen Zhang; Li-Qing Chen; De-Zhi Li; Nan-Jie Zhou; Tu-Liang Liang; Lu Gan; Xiao-Ting Peng; Yuan-Yuan Song; Jun Zheng; Yujuan Zhan; Hu-Dan Pan; Quan Liu; Yicheng Zhao; Liang Liu; Run-Ze Li

doi:10.1016/j.eng.2026.02.033

工程（英文） ›› 2026, Vol. 62 ›› Issue (7) : 143 -165. DOI: 10.1016/j.eng.2026.02.033

研究论文

肺癌中异常磷脂代谢是启动恶性转化、增强细胞存活的开关

Wei-Qian Bao ^a^,^# ,
Tian-Tian Xu ^a^,^# ,
Bi-Qing Huang ^a^,^# ,
Shu-Qin Li ^a^,^# ,
Meng-Lin Jiang ^a ,
Gang-Yuan Ma ^b ,
Cui-Fen Zhang ^a ,
Li-Qing Chen ^b ,
De-Zhi Li ^a ,
Nan-Jie Zhou ^c ,
Tu-Liang Liang ^d ,
Lu Gan ^a ,
Xiao-Ting Peng ^a ,
Yuan-Yuan Song ^a ,
Jun Zheng ^a ,
Yujuan Zhan ^a ,
Hu-Dan Pan ^a ,
Quan Liu ^a ,
Yicheng Zhao ^a^,^* ,
Liang Liu ^a^,^b^,^* ,
Run-Ze Li ^a^,^*

作者信息 +

The Phospholipid Metabolic Switch in Lung Cancer: Igniting Transformation, Fortifying Survival, and Informing Therapy

Wei-Qian Bao ^a^,^# ,
Tian-Tian Xu ^a^,^# ,
Bi-Qing Huang ^a^,^# ,
Shu-Qin Li ^a^,^# ,
Meng-Lin Jiang ^a ,
Gang-Yuan Ma ^b ,
Cui-Fen Zhang ^a ,
Li-Qing Chen ^b ,
De-Zhi Li ^a ,
Nan-Jie Zhou ^c ,
Tu-Liang Liang ^d ,
Lu Gan ^a ,
Xiao-Ting Peng ^a ,
Yuan-Yuan Song ^a ,
Jun Zheng ^a ,
Yujuan Zhan ^a ,
Hu-Dan Pan ^a ,
Quan Liu ^a ,
Yicheng Zhao ^a^,^* ,
Liang Liu ^a^,^b^,^* ,
Run-Ze Li ^a^,^*

Author information +

文章历史 +

摘要

肺癌是全球癌症相关死亡的主要原因之一，发病机制复杂，其中炎症与恶性转化的关联备受关注。本文聚焦磷脂代谢在肺癌炎癌转化中的核心作用，系统阐述磷脂代谢驱动该转化过程的分子机制、对免疫微环境的影响、参与细胞死亡抗性的过程，以及从肺癌到泛癌的临床转化策略，并探讨磷脂代谢研究中的争议与未来展望。通过对相关文献的综合分析，本综述旨在为肺癌的预防、诊断与治疗提供新的思路与理论基础。

Abstract

Lung cancer, as one of the leading causes of cancer-related deaths worldwide, exhibits complex pathogenesis, with the association between inflammation and malignant transformation drawing significant attention. This paper focuses on the pivotal role of phospholipid metabolism in the inflammation-to-cancer transition of lung cancer. It systematically elucidates the molecular mechanisms by which phospholipid metabolism drives this transition, its impact on the immune microenvironment, its involvement in cell death resistance processes, and clinical translation strategies from lung cancer to pan-cancer types. Furthermore, it explores controversies and future prospects in phospholipid metabolism research. Through comprehensive analysis of relevant literature, this review aims to provide novel insights and theoretical foundations for the prevention, diagnosis, and treatment of lung cancer.

关键词

磷脂代谢 / 肺癌 / 炎癌转化 / 免疫微环境 / 临床转化策略

Key words

Phospholipid metabolism / Lung cancer / Inflammation-to-cancer transition / Immune microenvironment / Clinical translation strategies

引用本文

引用格式 ▾

Wei-Qian Bao,Tian-Tian Xu,Bi-Qing Huang,Shu-Qin Li,Meng-Lin Jiang,Gang-Yuan Ma,Cui-Fen Zhang,Li-Qing Chen,De-Zhi Li,Nan-Jie Zhou,Tu-Liang Liang,Lu Gan,Xiao-Ting Peng,Yuan-Yuan Song,Jun Zheng,Yujuan Zhan,Hu-Dan Pan,Quan Liu,Yicheng Zhao,Liang Liu,Run-Ze Li. 肺癌中异常磷脂代谢是启动恶性转化、增强细胞存活的开关[J]. 工程（英文）, 2026, 62(7): 143-165 DOI:10.1016/j.eng.2026.02.033