^a Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA

^b Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583 Singapore

^c Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456 Singapore

^d The N.1 Institute for Health (N.1), National University of Singapore, Singapore 117456 Singapore

^e Miner School of Computer and Information Sciences, University of Massachusetts Lowell, MA 01854, USA

^f Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600 Singapore

^g The Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), National University of Singapore, Singapore 117456 Singapore

^h Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA

ⁱ Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA