八子补肾胶囊通过恢复AhR–miR-23a介导的线粒体能量代谢改善更年期肥胖引发的认知损伤

Xiaobin An; Wentao Xu; Haining Chen; Mingyou Zhang; Xiaojing Zhong; Jing Liu; Haihui Chen; Xinyue Zhao; Yan Wu; Jing Li; Jinan Yang; Meijie Chen; Lu Zeng; Jing Ma; Xuqiao Wang; Hongrong Li; Yanpeng Xue; Qin Wang; Dongyang Wang; Guitian Cong; Yunlong Hou; Zhenhua Jia; Jing Ai

doi:10.1016/j.eng.2026.05.005

工程（英文） ›› 2026, Vol. 65 ›› Issue (10) : 237 -254. DOI: 10.1016/j.eng.2026.05.005

八子补肾胶囊通过恢复AhR–miR-23a介导的线粒体能量代谢改善更年期肥胖引发的认知损伤

Xiaobin An ^a^,^# ,
Wentao Xu ^a^,^# ,
Haining Chen ^a^,^# ,
Mingyou Zhang ^a ,
Xiaojing Zhong ^a ,
Jing Liu ^a ,
Haihui Chen ^a ,
Xinyue Zhao ^a ,
Yan Wu ^a ,
Jing Li ^e ,
Jinan Yang ^a ,
Meijie Chen ^a ,
Lu Zeng ^a ,
Jing Ma ^a ,
Xuqiao Wang ^a ,
Hongrong Li ^c^,^d ,
Yanpeng Xue ^a ,
Qin Wang ^a ,
Dongyang Wang ^a ,
Guitian Cong ^a ,
Yunlong Hou ^c^,^d ,
Zhenhua Jia ^b^,^c^,^* ,
Jing Ai ^a^,^*

作者信息 +

Bazi Bushen Capsule Rescues Menopausal Obesity-Induced Cognitive Impairment by Restoring AhR-miR-23a-Dependent Mitochondrial Bioenergetics

Xiaobin An ^a^,^# ,
Wentao Xu ^a^,^# ,
Haining Chen ^a^,^# ,
Mingyou Zhang ^a ,
Xiaojing Zhong ^a ,
Jing Liu ^a ,
Haihui Chen ^a ,
Xinyue Zhao ^a ,
Yan Wu ^a ,
Jing Li ^e ,
Jinan Yang ^a ,
Meijie Chen ^a ,
Lu Zeng ^a ,
Jing Ma ^a ,
Xuqiao Wang ^a ,
Hongrong Li ^c^,^d ,
Yanpeng Xue ^a ,
Qin Wang ^a ,
Dongyang Wang ^a ,
Guitian Cong ^a ,
Yunlong Hou ^c^,^d ,
Zhenhua Jia ^b^,^c^,^* ,
Jing Ai ^a^,^*

Author information +

文章历史 +

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Abstract

Postmenopausal women with obesity are at a significantly elevated risk of cognitive impairment. There is therefore an urgent need to uncover the underlying mechanisms of this impairment and develop effective therapeutic strategies. In this study, we demonstrated that treatment with the traditional Chinese herbal formulation Bazi Bushen capsule (BZBS; 1.4 and 2.8 g∙kg^-1∙d^-1) significantly alleviated cognitive deficits and restored hippocampal theta rhythm power and frequency in ovariectomized (OVX) high-fat diet-fed (OXHF) mice. Furthermore, we showed that BZBS improved mitochondrial function in the hippocampus, as evidenced by mitochondrial crista structure restoration, decreased reactive oxygen species (ROS) accumulation, and reduced adenosine triphosphate (ATP) depletion. By integrating bioinformatic, molecular, and neurophysiological methods, we found that BZBS inhibited the aryl hydrocarbon receptor (AhR)-miR-23a axis, which reactivated both the nicotinamide phosphoribosyltransferase (NAMPT)-nicotinamide adenine dinucleotide (NAD⁺)-sirtuin 1 (SIRT1) and proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)-SIRT3 pathways, thus restoring mitochondrial function and increasing ATP levels. This study mechanistically validated the Qi-replenishing bioactivity of BZBS, which aligned with its therapeutic mechanism as informed by traditional Chinese medicine theory. Our findings identified BZBS as a promising therapeutic candidate for alleviating cognitive decline induced by menopausal obesity. Moreover, by elucidating the mechanisms of BZBS at the molecular level, we established a crucial foundation for the clinical use of this Chinese herbal medicine.

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Key words

Bazi Bushen capsule / Menopausal obesity / AhR-miR-23a axis / Mitochondrial dysfunction / Cognitive impairment

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Xiaobin An,Wentao Xu,Haining Chen,Mingyou Zhang,Xiaojing Zhong,Jing Liu,Haihui Chen,Xinyue Zhao,Yan Wu,Jing Li,Jinan Yang,Meijie Chen,Lu Zeng,Jing Ma,Xuqiao Wang,Hongrong Li,Yanpeng Xue,Qin Wang,Dongyang Wang,Guitian Cong,Yunlong Hou,Zhenhua Jia,Jing Ai. 八子补肾胶囊通过恢复AhR–miR-23a介导的线粒体能量代谢改善更年期肥胖引发的认知损伤[J]. 工程（英文）, 2026, 65(10): 237-254 DOI:10.1016/j.eng.2026.05.005