¹⁹F磁共振成像(MRI) 的研究可追溯到30多年前。在这30多年间，氢原子核(¹H)成像技术迅速发展，并在全球得到广泛应用，使得磁共振成像成为生物医学诊断成像技术中不可缺少的支柱。多年来，由于各种原因，对¹⁹F成像技术的研究进展缓慢。但是在过去的十年间，尤其是最近几年，¹⁹F成像的研究和临床相关性呈爆发式发展。部分原因归结为MRI仪器、¹⁹F/¹H线圈设计以及临床前和临床核磁共振仪的超高速脉冲序列的发展。这些成就再加上对解剖生理学分子成像技术的兴趣以及一批创新造影剂的出现使¹⁹F的概念进入了早期的临床评估中。本篇综述重点探讨以液态全氟化碳化合物为基础的造影剂，并试图呈现这段丰富的研究和发展历史。

The research roots of ¹⁹fluorine (¹⁹F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, ¹H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, ¹⁹F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of ¹⁹F imaging has exploded. In part, this is due to advances in MRI instrumentation, ¹⁹F/¹H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of ¹⁹F into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.