首次从猪体内分离鉴定人苍白杆菌

工程（英文） ›› 2020, Vol. 6 ›› Issue (1) : 49 -55. DOI: 10.1016/j.eng.2019.08.014

研究论文

首次从猪体内分离鉴定人苍白杆菌

谷世江 ^a^,^* ,
侯瑞卿 ^a^,^* ,
高盛果 ^a ,
孙哲 ^a ,
李向东 ^a ,
翟路峰 ^a ,
金云云 ^a ,
朱巧艳 ^a ,
廖永洪 ^a ,
田克恭 ^a^,^b

作者信息 +

First Isolation and Characterization of Ochrobactrum anthropi from Pig

Shijiang Gu ^a^,^* ,
Ruiqing Hou ^a^,^* ,
Shengguo Gao ^a ,
Zhe Sun ^a ,
Xiangdong Li ^a ,
Lufeng Zhai ^a ,
Yunyun Jin ^a ,
Qiaoyan Zhu ^a ,
Yonghong Liao ^a ,
Kegong Tian ^a^,^b

Author information +

文章历史 +

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摘要

从具有神经症状的临床发病猪的脑中分离出一株革兰氏阴性杆菌，该猪脑组织病理检查结果显示有脑膜炎。从大脑样本中成功分离的这株菌经生化反应（API 20 NE）鉴定为人苍白杆菌（O. anthropi ），并通过基因测序进行了确证。该菌株对β -内酰胺类抗生素高度耐药。用该O. anthropi 分离株对小鼠进行攻毒试验，结果感染小鼠显示出典型的脑膜炎症状。这是首次报道从猪体内分离O. anthropi，表明O. anthropi 可能具有更广泛的宿主感染谱。

Abstract

One Gram-negative bacillus was isolated from a brain sample of a pig with neurological symptoms. Pathological examination showed meningitis at necropsy. Ochrobactrum anthropi (O. anthropi) was successfully isolated from the brain sample and was confirmed by biochemical reaction results (API 20 NE) and gene sequencing. The strain was highly resistant to beta-lactam antibiotics. Mice were experimentally infected with O. anthropi and showed typical meningitis. This is the first report on O. anthropi isolated from a pig, and indicates that O. anthropi may have a broader host spectrum of infection.