再生医学中器官生物打印的进展

工程（英文） ›› 2024, Vol. 42 ›› Issue (11) : 129 -152. DOI: 10.1016/j.eng.2024.04.023

研究论文

再生医学中器官生物打印的进展

王象 ^a ,
张迪 ^a ,
Yogendra Pratap Singh ^b^,^c ,
Miji Yeo ^b^,^c ,
邓国滔 ^a ,
赖嘉琪 ^a ,
陈飞 ^a^,^* ,
Ibrahim T. Ozbolat ^b^,^c^,^d^,^e^,^f^,^g^,^h^,^* ,
于寅 ^a^,^*

作者信息 +

Progress in Organ Bioprinting for Regenerative Medicine

Xiang Wang ^a^,^# ,
Di Zhang ^a^,^# ,
Yogendra Pratap Singh ^b^,^c ,
Miji Yeo ^b^,^c ,
Guotao Deng ^a ,
Jiaqi Lai ^a ,
Fei Chen ^a^,^* ,
Ibrahim T. Ozbolat ^b^,^c^,^d^,^e^,^f^,^g^,^h^,^* ,
Yin Yu ^a^,^*

Author information +

^aCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

^bThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA

^cEngineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA

^dDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

^eMaterials Research Institute, Pennsylvania State University, University Park, PA 16802, USA

^fDepartment of Neurosurgery, Pennsylvania State College of Medicine, Hershey 17033, PA, USA

^gPennsylvania State Cancer Institute, Pennsylvania State University, University Park, PA 16802, USA

^hBiotechnology Research and Application Center, Cukurova University, Adana 01130, Türkiye

^bThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA

^cEngineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA

^dDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

^eMaterials Research Institute, Pennsylvania State University, University Park, PA 16802, USA

^fDepartment of Neurosurgery, Pennsylvania State College of Medicine, Hershey 17033, PA, USA

^gPennsylvania State Cancer Institute, Pennsylvania State University, University Park, PA 16802, USA

^hBiotechnology Research and Application Center, Cukurova University, Adana 01130, Türkiye

E⁃mail addresses: fei.chen1@siat.ac.cn (F. Chen),

ito1@psu.edu (I.T. Ozbolat),

yin.yu@siat.ac.cn(Y. Yu)

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文章历史 +

Received	Accepted	Published
2024-01-15	2024-04-27
Issue Date
2024-04-27

PDF (4344K)

摘要

由损伤、疾病及衰老导致的器官损伤或衰竭，因人体再生能力有限而构成重大医疗挑战。器官移植则面临供体短缺与免疫排斥风险的双重困境，因此亟需创新的解决方案。按需的三维生物打印器官技术为组织工程与再生医学领域带来新希望。本文系统阐述了前沿生物打印技术进展，重点剖析生物墨水选择和细胞类型优化策略。继而探讨心脏、肝脏、肾脏及胰腺等实体器官的生物打印突破，强调血管化与细胞整合的关键作用。最后，针对生物打印器官的临床转化及其大规模生产中的核心挑战与发展方向提出见解。

Abstract

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

关键词

器官打印 / 3D生物打印 / 再生医学 / 组织工程

Key words

Organ printing / Three-dimensional bioprinting / Regenerative medicine / Tissue engineering

引用本文

引用格式 ▾

王象, 张迪, Yogendra Pratap Singh, Miji Yeo, 邓国滔, 赖嘉琪, 陈飞, Ibrahim T. Ozbolat, 于寅再生医学中器官生物打印的进展[J]. 工程（英文）, 2024, 42(11): 129-152 DOI:10.1016/j.eng.2024.04.023