18F-FLT PET能监测食管鳞癌放疗过程中肿瘤和正常组织的生物学变化，其较18F-FDG PET能较好区分炎症和肿瘤，能检测食管肿瘤放疗过程中的加速再增殖,18F-FETNIM PET能检测食管鳞癌的乏氧状态,18F-FLT PET和18F-FETNIM PET作为一种非创伤性的影像学技术，能为肿瘤医生提供一个早期评价治疗反应，检测放疗过程中的再增殖克隆源细胞、乏氧和评价新辅助治疗疗效的手段。18F-FLT PET和18F-FETNIM PET能为放射治疗确定“再增殖”和“乏氧”生物学靶区，以通过剂量调强放疗提高再增殖和乏氧区域放疗剂量，提高肿瘤的局部控制率和远期生存。

18F-FLT uptake can be used to monitor the biological response of esophageal SCC and normal tissue to RT. Increased uptake of 18F-FLT following treatment interruptions may reflect accelerated repopulation. 18F-FLT PET may have advantages compared to 18F-FDG PET in differentiating inflammation from tumor. 18F-FLT PET may help oncologists predict treatment response as early as one week after the beginning of treatment and estimate clonogenic repopulation during RT. 18F-FETNIM PET can depict hypoxia in esophageal SCC. Prior to CCRT, tumor hypoxia demonstrates spatial variability in different days, though overall 18F-FETNIM uptake remains similar. Baseline SUVmax may be predictive of treatment response.

于金明（1958—），男，山东潍坊市人，中国工程院院士，研究方向为肿瘤放射治疗