目的 了解HIFU技术治疗癌瘤的临库效果和安全性。方法 应用FEP-BY01型高能聚焦超声肿瘤治疗机临床治疗78例中晚期腹腔、盆腔、多种脏器癌瘤，并将全部病例分为空腔脏器和实质脏器癌瘤两大类，按各自的标准进行疗效判断，并从疼痛、皮肤的灼伤、腔肠出血、穿孔及其它方面进行安全判断。结果 空腔脏器肿瘤32例，出院时65.6%肿瘤脱落消失，34.4%萎缩。实质脏器癌瘤46例；治疗后15.6%显著疗效，80.4%有效，无效4.3%（因肋骨阻挡），与放化疗合用可加速肿瘤脱落或萎缩。结论 HIFU技术对控制肿瘤有肯定疗效，并且安全可靠，值得推广应用；其相关医学基础研究须尽快开展。

Aim To evaluate the clinical effect and safety of high intensive focused ultrasound (HIFU). Methods 78 cases malignant tumors in abdomen and pelvis were classified into two groups： hollow organic tumors group such as carcinomas of ractum and bladder etc. and solid organic tumors group such as carcinomas of liver and pancreas etc. were treated by FEP-BY01 pyrotherapier. The clinical effect was evaluated by different criterion according to their group and the safety was evaluated from painness, skin burning, intestine bleeding, perforation and other aspects. Results In 32 cases of hollow organic tumors, CR (Complete Remission) is 65. 6%, PR (Partial Remission) is 34. 4% at discharge. In 46 cases of solid organic tumors, marked effect rate is 15. 6%, effect rate is 80. 4%, and non-effect rate is 4. 3% (because of ribber stopping ultrasound). HIFU combined with a lower dosage radiotherapy and chemotherapy can speed up tumor falling off or atrophy. Conclusions The HIFU is a kind of safe and effective method to treat abdominal malignant tumor, worth being popularized.