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《工程(英文)》 >> 2022年 第14卷 第7期 doi: 10.1016/j.eng.2021.04.018

大鼠周围神经诱发脑皮层电位时空图——一种研究脑对周围神经反应模式的新方法

Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, China

# These authors contributed equally to this work.

收稿日期: 2020-12-05 修回日期: 2021-03-31 录用日期: 2021-04-06 发布日期: 2021-06-10

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摘要

将大脑作为一个整体,观察周围神经受到刺激后大脑反应的动态过程,是深入了解脑功能的基础,也是一个科学难题。本研究发展了一种新型大鼠脑皮层诱发电位微创正交记录方法,结果显示,在该方法下,刺激大鼠正中神经、尺神经和桡神经及其分支,首次获得了可重复、具有不同波形特点、可辨别的脑皮层诱发电位图谱,并将其时空变化规律以可视化的方式呈现出来。此外本研究也记录了正中神经离断4个月后,大鼠脑皮层诱发电位的变化。结果表明,大脑皮层对周围神经刺激的反应具有精确和可重复的时空顺序。本实验方法和波形图谱可作为测试平台用于探索周围神经系统和脑中枢神经系统之间的整体功能交互与动态重塑的时相机制。

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