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《医学前沿(英文)》 页码 867-877 doi: 10.1007/s11684-023-0995-9
关键词: COVID-19 Sinopharm/BBIBP vaccine immunocompromised patients real-world
Innovation-driven trend shaping COVID-19 vaccine development in China
《医学前沿(英文)》 doi: 10.1007/s11684-023-1034-6
《化学科学与工程前沿(英文)》 2022年 第16卷 第6期 页码 973-984 doi: 10.1007/s11705-021-2123-1
关键词: pickering emulsion vaccine adjuvant alum-stabilised emulsion oleic to linoleic acid ratio stability
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
《医学前沿(英文)》 2008年 第2卷 第1期 页码 51-57 doi: 10.1007/s11684-008-0010-5
关键词: antitumor therapy occurrence implantation DNA vaccine SART3 DNA
李爱花,杨雪梅,孙轶楠,苑亚坤,杨俊涛
《中国工程科学》 2021年 第23卷 第4期 页码 153-161 doi: 10.15302/J-SSCAE-2021.04.018
应对新型冠状病毒肺炎(COVID-19)疫情防控的迫切需求,核酸疫苗以其快速高效的优点得到了疫苗研发领域的高度重视,特别是信使核糖核酸(mRNA)疫苗的研发进程显著加快,首次获批上市并在人体中使用。本文从核酸疫苗及相关技术概念、研发轨迹与发展趋势等方面总结梳理核酸疫苗的研发态势,辨识核酸疫苗特征,分析 COVID-19 疫情对 mRNA疫苗研究的促进作用,梳理核酸疫苗拓展应用的主要领域,针对可能存在的技术性、安全性问题开展深入讨论。研究建议,从改良目的基因表达、完善递送系统、提高免疫应答、增强 mRNA 稳定性及易存性等方面着手,着力开展核酸疫苗的关键技术开发;严格监管核酸疫苗的安全性和有效性;引导利益相关方对具有安全性风险、可能对肿瘤与传染病防控带来颠覆性影响的 mRNA 疫苗技术开展改进研究,注重技术研发的前瞻布局并促进应用转化。
关键词: 核酸疫苗 脱氧核糖核酸(DNA)疫苗 核糖核酸(RNA)疫苗 信使核糖核酸(mRNA)疫苗 新型冠状病毒肺 炎 肿瘤
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 30-42 doi: 10.1007/s11684-019-0721-9
关键词: HIV-1 broadly neutralizing antibodies Env conformational states vaccine design SOSIP
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 490-498 doi: 10.1007/s11684-016-0470-y
This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DNA technology. A total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another 15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine. Furthermore, the third group of 15 young mice was inoculated with phosphate buffer saline as control. The immunized mice were inoculated with pneumococcus in the middle ear. Results showed that IgG antibody responses against both the PsaA protein and Hib polysaccharide were observed in the Hib-PsaA group. However, no statistical difference was observed in the titer of IgG against the Hib polysaccharide between Hib-PsaA and Hib-TT groups. The elimination rate of pneumococcus and the inflammation of the middle ear showed the effectiveness of protective immunity against otitis media caused by pneumococcus. Our results suggest that the Hib polysaccharide can be successfully conjugated with rPsaA via amide condensation. This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young mice and elicit effective protection against acute otitis media caused by pneumococcus.
关键词: conjugate vaccine pneumococcal surface adhesin A Hemophilus influenzae b immunogenicity otitis media
药品监管科学推动中国新冠病毒疫苗研发概述 Review
黄志明, 付志浩, 王军志
《工程(英文)》 2022年 第10卷 第3期 页码 127-132 doi: 10.1016/j.eng.2022.01.001
监管科学是一门综合应用自然科学、社会科学和人文科学,开发新工具、新标准和新方法,以评估受监管产品的安全性、有效性、质量和性能的学科。监管科学研究的根本目的是为行政决策提供技术支撑。在甲型H1N1流感、严重急性呼吸综合征(SARS)和中东呼吸综合征(MERS)等传染病大流行期间,监管科学研究有力支持了抗病毒药物和疫苗的研发。特别在新型冠状病毒(简称新冠病毒)肺炎(COVID-19)疫情大流行期间,药品监管科学支持下的疫苗研发在疫情防控中发挥了重要作用。本文总结了中国疫苗产业、新冠病毒疫苗研发以及疫苗监管科学发展的总体概况。此外,本文重点从国家规划、法律法规、技术指南、质量控制和疫苗上市后监管等方面,回顾和分析了监管科学研究为推动中国新冠病毒疫苗研发所发挥的重要作用。本文为当前大流行阶段以及后疫情时代的疫苗研发策略制定提供参考,并为将来如何更好地应对新发和再发传染病提供借鉴和指导。
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Vaccine therapies for chronic hepatitis B: can we go further?
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 17-23 doi: 10.1007/s11684-014-0313-7
Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.
关键词: chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine
Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant
《医学前沿(英文)》 2023年 第17卷 第3期 页码 576-580 doi: 10.1007/s11684-023-0991-0
关键词: variant
《医学前沿(英文)》 2022年 第16卷 第2期 页码 185-195 doi: 10.1007/s11684-021-0913-y
immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis
Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 66-72 doi: 10.15302/J-FASE-2015047
关键词: Neospora caninum immune mapped protein 1 (IMP1) vaccine candidate BALB/c mice
Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus
Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN
《农业科学与工程前沿(英文)》 2015年 第2卷 第3期 页码 216-222 doi: 10.15302/J-FASE-2015072
关键词: pseudorabies virus glycoprotein B protein subunit vaccine
标题 作者 时间 类型 操作
Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective
期刊论文
Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine
期刊论文
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
期刊论文
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
期刊论文
Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine
null
期刊论文
virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine
null
期刊论文
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic
期刊论文
immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis
Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU
期刊论文