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Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿(英文)》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 260-267 doi: 10.15302/J-FASE-2016116
关键词: antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.
关键词: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 314-329 doi: 10.1007/s11684-018-0625-0
关键词: cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO
《农业科学与工程前沿(英文)》 2016年 第3卷 第2期 页码 147-152 doi: 10.15302/J-FASE-2016099
Advances in immunopathogenesis of adult immune thrombocytopenia
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 418-424 doi: 10.1007/s11684-013-0297-8
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.
关键词: primary immune thrombocytopenia B lymphocytes T lymphocytes antigen-presenting cells cytokines
《医学前沿(英文)》 2022年 第16卷 第6期 页码 909-918 doi: 10.1007/s11684-021-0890-1
关键词: acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker
Non-genetic mechanisms of diabetic nephropathy
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 319-332 doi: 10.1007/s11684-017-0569-9
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.
关键词: diabetic nephropathy immune inflammatory response epithelial–mesenchymal transition apoptosis mitochondrial damage epigenetics podocyte–endothelial communication
Metformin and metabolic diseases: a focus on hepatic aspects
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
关键词: metformin diabetes hepatic steatosis inflammatory response insulin resistance
左炔诺孕酮宫内释放系统对胰岛素样生长因子-1的影响与预防盆腔炎的相关性研究
吴晓杰,刘霞,陶跃平,王洁
《中国工程科学》 2015年 第17卷 第6期 页码 4-7
目的:研究左炔诺孕酮宫内释放系统对子宫内膜组织胰岛素样生长因子-1(IGF-1)的影响及预防盆腔炎疗效分析。方法:选取2010―2013年在嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者450例进行随机分组,研究组术后子宫内即时放置左炔诺孕酮宫内释放系统,而对照组不予放置。分别对术前及术后6个月子宫内膜组织IGF-1的表达情况进行对比,且随访2年,了解患者盆腔炎发生情况。结果:所有手术均成功,研究组子宫内膜组织IGF-1表达术后明显低于术前,对照组术前及术后子宫内膜组织IGF-1表达变化无差异,二组相比,术后IGF-1表达差异有显著性。随访2年对照组224例患者中39例发生盆腔炎,复发率为10.89 %,而研究组184例发生盆腔炎12例,差异有显著性;研究组子宫内膜厚度术后明显小于术前,差异有显著性,对照组子宫内膜厚度术后与术前变化无差异性。结论:左炔诺孕酮宫内释放系统对子宫内膜的IGF-1表达存在抑制作用,可能是其抑制子宫内膜增生并减少盆腔炎发生的机制之一。
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,
《工程(英文)》 doi: 10.1016/j.eng.2023.06.007
关键词: Axin1 Bacteria Microbiome inflammation Inflammatory bowel disease Immunity Microbiome Paneth cells Akkermansia muciniphila Wnt
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
《医学前沿(英文)》 2021年 第15卷 第2期 页码 232-251 doi: 10.1007/s11684-020-0797-2
关键词: non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders alloimmune responses pregnancy mature MDSCs multiple sclerosis Yin-Yang law of MDSCs
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
单克隆抗体治疗过敏性疾病的研究现状 Review
陈彦, 王炜, 袁慧慧, 李艳, 吕喆, 崔烨, 刘杰, 孙英
《工程(英文)》 2021年 第7卷 第11期 页码 1552-1556 doi: 10.1016/j.eng.2020.06.029
过敏性疾病是常见的慢性疾病之一,由变应原在不同器官上引发变态反应,在临床上以不同器官的疾病为主要表现形式,如哮喘、特应性皮炎、鼻-鼻窦炎等,常累及儿童和成人。由于其在世界范围内的广泛流行和对患者生活质量的影响,采用新型生物疗法治疗过敏性疾病的研究业已成为该领域的热点。已知多种因素可促进或触发Th2 型免疫应答,导致2 型细胞因子和免疫球蛋白E(IgE)的产生并参与过敏性疾病的发生发展,因此,开发针对2 型细胞因子和IgE 的单克隆抗体为治疗过敏性疾病提供了新的策略。此外,一些潜在的靶点,如上皮源性预警素-胸腺基质淋巴细胞生成素(TSLP)和白介素33(IL-33)业已进入临床研究阶段。这些新的和潜在的靶点极大地提高了变应性疾病的治疗机会。本文阐述了目前已开发的针对细胞因子、细胞因子受体和IgE 的单克隆抗体在过敏性疾病治疗中的作用,并对这些抗体的临床效果进行了讨论和分析。
标题 作者 时间 类型 操作
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
期刊论文
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
期刊论文
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文
The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows
Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO
期刊论文
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia
期刊论文
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,
期刊论文
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
期刊论文
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文