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Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
Low-dose CT for lung cancer screening: opportunities and challenges
null
《医学前沿(英文)》 2018年 第12卷 第1期 页码 116-121 doi: 10.1007/s11684-017-0600-1
Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when low-dose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States. On the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populations by several clinical guidelines. However, results from the following independent RCTs in Europe failed to show consistent conclusions. In addition, intractable problems gradually emerged with the progress of LDCT screening. This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancer. Before spreading implementation of LDCT screening, challenges, including high false-positive rates, overdiagnosis, enormous costs, and radiation risk, must be addressed. Complementary biomarkers and technical improvement are expected in the field of lung cancer screening in the near future.
关键词: lung cancer low-dose computerized tomography early detection opportunities challenges
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 288-295 doi: 10.1007/s11684-012-0208-4
Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg-1·h-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg-1·h-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg-1?h-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?h-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?h-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.
关键词: tramadol minimum effective dose postoperative analgesia infants continual reassessment method
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1733-x
关键词: Bioaugmentation Low-dose persulfate oxidation Polycyclic aromatic hydrocarbon Remediation
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
《医学前沿(英文)》 2022年 第16卷 第1期 页码 93-101 doi: 10.1007/s11684-021-0914-x
关键词: COVID-19 SARS-CoV-2 vaccine immunization booster immunization
Data-driven approach to solve vertical drain under time-dependent loading
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 696-711 doi: 10.1007/s11709-021-0727-7
关键词: vertical drain artificial neural network time-dependent loading deep learning network genetic algorithm particle swarm optimization
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 506-509 doi: 10.1007/s11684-013-0294-y
This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in the city of Lhasa, China. Seven out of the twenty-six hospitals registered with the Lhasa Health Bureau were included in the investigation. The entrance surface air Kerma (ESAK) of seven conventional screen-film radiology X-ray equipment in these hospitals was measured with a QA dosimeter in September 2012. The X-ray examinations were divided into three categories: PA (posterior-anterior) chest, upper/lower limb, and AP (anterior-posterior) lumbar spine. For each category, ESAKs were calculated and analyzed. The mean ESAK was 0.6 mGy for PA chest, 0.3 mGy for upper/lower limb, and 1.8 mGy for AP lumbar spine. In addition, the mean ESAK value recorded for PA chest X-ray examinations exceeded the corresponding value recommended by the International Atomic Energy Agency (0.4 mGy).
关键词: radiation dosage radiology radiation protection radiography/statistics & numerical data
Chloride binding and time-dependent surface chloride content models for fly ash concrete
S. MUTHULINGAM,B. N. RAO
《结构与土木工程前沿(英文)》 2016年 第10卷 第1期 页码 112-120 doi: 10.1007/s11709-015-0322-x
关键词: binding isotherms chloride ingress concrete fly ash surface chloride content
《医学前沿(英文)》 2023年 第17卷 第1期 页码 119-131 doi: 10.1007/s11684-022-0949-7
关键词: GDF15 esophageal squamous cell carcinoma chemoresistance cellular metabolism TGFBR2 AKT
Effect of chemical dose on phosphorus removal and membrane fouling control in a UCT-MBR
Guangrong Sun, Chuanyi Zhang, Wei Li, Limei Yuan, Shilong He, Liping Wang
《环境科学与工程前沿(英文)》 2019年 第13卷 第1期 doi: 10.1007/s11783-019-1085-8
关键词: University of Cape Town Bioreactor (UCT-MBR) enhanced nutrients removal aluminum sulfate sludge activity membrane fouling
《医学前沿(英文)》 2023年 第17卷 第2期 页码 231-239 doi: 10.1007/s11684-022-0939-9
关键词: neoadjuvant radiotherapy oligometastatic prostate cancer radical prostatectomy
Pankaj SHARMA,Ajai JAIN
《机械工程前沿(英文)》 2014年 第9卷 第4期 页码 380-389 doi: 10.1007/s11465-014-0315-9
Stochastic dynamic job shop scheduling problem with consideration of sequence-dependent setup times are among the most difficult classes of scheduling problems. This paper assesses the performance of nine dispatching rules in such shop from makespan, mean flow time, maximum flow time, mean tardiness, maximum tardiness, number of tardy jobs, total setups and mean setup time performance measures viewpoint. A discrete event simulation model of a stochastic dynamic job shop manufacturing system is developed for investigation purpose. Nine dispatching rules identified from literature are incorporated in the simulation model. The simulation experiments are conducted under due date tightness factor of 3, shop utilization percentage of 90 % and setup times less than processing times. Results indicate that shortest setup time (SIMSET) rule provides the best performance for mean flow time and number of tardy jobs measures. The job with similar setup and modified earliest due date (JMEDD) rule provides the best performance for makespan, maximum flow time, mean tardiness, maximum tardiness, total setups and mean setup time measures.
关键词: scheduling stochastic dynamic job shop sequence-dependent setup times dispatching rule simulation
Cancer and the environment: Filling knowledge gaps together
Linda S. BIRNBAUM PhD, DABT, ATS,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 131-133 doi: 10.1007/s11684-010-0044-3
关键词: environment genes environmental exposure environmental agent persistence chemicals inert ingredients low dose
Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 593-599 doi: 10.1007/s11684-018-0635-y
Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis. Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials on applying venetoclax in combination with cytarabine and other agents to treat various hematological malignancies are currently underway. Here, we present a case of a male patient with poor performance status and who developed AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patient with high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine and venetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematological malignancies.
关键词: venetoclax cytarabine AML leukemia
Meiju YANG,Chunxia LI,Guoying GU,Limin ZHU
《机械工程前沿(英文)》 2015年 第10卷 第1期 页码 37-42 doi: 10.1007/s11465-015-0326-1
In this paper, a novel rate-dependent Prandtl-Ishlinskii (P-I) model is proposed to characterize the rate-dependent hysteresis nonlinearity of piezoelectric actuators. The new model is based on a modified rate-dependent play operator, in which a dynamic envelope function is introduced to replace the input function of the classical play operator. Moreover, a dynamic density function is utilized in the proposed P-I model. The parameters of the proposed model are identified by a modified particle swarm optimization algorithm. Finally, experiments are conducted on a piezo-actuated nanopositioning stage to validate the proposed P-I model under the sinusoidal inputs. The experimental results show that the developed rate-dependent P-I model precisely characterize the rate-dependent hysteresis loops up to 1000 Hz.
关键词: piezoelectric actuators hysteresis Prandtl-Ishlinskii rate-dependent
标题 作者 时间 类型 操作
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文
Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the
null
期刊论文
Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic
期刊论文
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
期刊论文
An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous
null
期刊论文
Chloride binding and time-dependent surface chloride content models for fly ash concrete
S. MUTHULINGAM,B. N. RAO
期刊论文
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal
期刊论文
Effect of chemical dose on phosphorus removal and membrane fouling control in a UCT-MBR
Guangrong Sun, Chuanyi Zhang, Wei Li, Limei Yuan, Shilong He, Liping Wang
期刊论文
radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation
期刊论文
Analysis of dispatching rules in a stochastic dynamic job shop manufacturing system with sequence-dependent
Pankaj SHARMA,Ajai JAIN
期刊论文
Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid
Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu
期刊论文