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Liquid-based high-temperature receiver technologies for next-generation concentrating solar power: A

《能源前沿（英文）》 2023年第17卷第1期页码 16-42 doi: 10.1007/s11708-023-0866-8

摘要： To reduce the levelized cost of energy for concentrating solar power (CSP), the outlet temperature of the solar receiver needs to be higher than 700 °C in the next-generation CSP. Because of extensive engineering application experience, the liquid-based receiver is an attractive receiver technology for the next-generation CSP. This review is focused on four of the most promising liquid-based receivers, including chloride salts, sodium, lead-bismuth, and tin receivers. The challenges of these receivers and corresponding solutions are comprehensively reviewed and classified. It is concluded that combining salt purification and anti-corrosion receiver materials is promising to tackle the corrosion problems of chloride salts at high temperatures. In addition, reducing energy losses of the receiver from sources and during propagation is the most effective way to improve the receiver efficiency. Moreover, resolving the sodium fire risk and material compatibility issues could promote the potential application of liquid-metal receivers. Furthermore, using multiple heat transfer fluids in one system is also a promising way for the next-generation CSP. For example, the liquid sodium is used as the heat transfer fluid while the molten chloride salt is used as the storage medium. In the end, suggestions for future studies are proposed to bridge the research gaps for > 700 °C liquid-based receivers.

关键词： next-generation concentrating solar power liquid-based solar receiver molten salt liquid metals

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Exploring the cancer genome in the era of next-generation sequencing

null

《医学前沿（英文）》 2012年第6卷第1期页码 48-55 doi: 10.1007/s11684-012-0182-x

摘要：

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genome studies. The increased efficiency and resolution of next-generation sequencing greatly facilitate the detection of genetic, genomic, and epigenomic alterations, such as single nucleotide mutations, small insertions and deletions, chromosomal rearrangements, copy number variations, and DNA methylation. Comprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptome sequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy. The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides an unprecedented insight into the landscape of genomic alterations in human sporadic cancers.

关键词： next-generation sequencing cancer genome whole genome sequencing exome transcriptome

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Emerging technologies to power next generation mobile electronic devices using solar energy

Dewei JIA , Yubo DUAN , Jing LIU ,

《能源前沿（英文）》 2009年第3卷第3期页码 262-288 doi: 10.1007/s11708-009-0015-z

摘要： Mobile electronic devices such as MP3, mobile phones, and wearable or implanted medical devices have already or will soon become a necessity in peoples’ lives. However, the further development of these devices is restricted not only by the inconvenient charging process of the power module, but also by the soaring prices of fossil fuel and its downstream chain of electricity manipulation. In view of the huge amount of solar energy fueling the world biochemically and thermally, a carry-on electricity harvester embedded in portable devices is emerging as a most noteworthy research area and engineering practice for a cost efficient solution. Such a parasitic problem is intrinsic in the next generation portable devices. This paper is dedicated to presenting an overview of the photovoltaic strategy in the chain as a reference for researchers and practitioners committed to solving the problem.

关键词： photovoltaic conversion energy harvesting solar cell maximum power point track algorithm PV electricity storage mobile/standalone PV application

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Towards a next-generation production system for industrial robots: A CPS-based hybrid architecture for

Qingmeng TAN, Yifei TONG, Shaofeng WU, Dongbo LI

《机械工程前沿（英文）》 2020年第15卷第1期页码 1-11 doi: 10.1007/s11465-019-0563-9

摘要： Given the multiple varieties and small batches, the production of industrial robots faces the ongoing challenges of flexibility, self-organization, self-configuration, and other “smart” requirements. Recently, cyber physical systems have provided a promising solution for the requirements mentioned above. Despite recent progress, some critical issues have not been fully addressed at the shop floor level, including dynamic reorganization and reconfiguration, ubiquitous networking, and time constrained computing. Toward the next generation production system for industrial robots, this study proposed a hybrid architecture for smart assembly shop floors with closed-loop dynamic cyber physical interactions. Aiming for dynamic reorganization and reconfiguration, the study also proposed modularized smart assembly units for the deployment of physical assembly processes. Enabling technologies, such as multiagent system (MAS), self-organized wireless sensor actuator networks, and edge computing, were discussed and then integrated into the proposed architecture. Furthermore, a multijoint robot assembly process was selected as a target scenario. Thus, an MAS was developed to simulate the coordination and negotiation mechanisms for the proposed architecture on the basis of the Java Agent Development Framework platform.

关键词： cyber physical system robot assembly multiagent system architecture

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航空发动机下一代适航规章制定策略和技术路径

尹泽勇,丁水汀,李果,邱天,刘传凯,周煜,綦蕾

《中国工程科学》 2022年第24卷第4期页码 230-239 doi: 10.15302/J-SSCAE-2022.04.020

摘要： Technical report on propulsion system and Auxiliary Power Unit APU related aircraft safety hazards [Administration , Aerospace Industries Association . 3rd technical report on propulsion system and Auxiliary Power

关键词：下一代适航规章航空发动机新规章架构系统安全要求

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量子密码竞赛产生下一代标准算法

Chris Palmer

《工程（英文）》 2023年第21卷第2期页码 6-8 doi: 10.1016/j.eng.2022.12.002

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

null

《医学前沿（英文）》 2013年第7卷第3期页码 280-289 doi: 10.1007/s11684-013-0265-3

摘要：

Many gene fusions have been recognized as important diagnostic and/or prognostic markers in human malignancies. In recent years, novel gene fusions have been identified in cases without prior knowledge of the genetic background. Accompanied by a powerful computational data analysis method, new genome-wide screening approaches were used to detect cryptic genomic aberrations. This review focused on advanced genome-wide screening approaches in fusion gene identification, such as microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression system. The fundamental rationale and strategy for fusion gene identification using each biotech platform are also discussed.

关键词： gene fusion cancer microarray next-generation sequencing NanoString nCounter system

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Impacts of solar multiple on the performance of direct steam generation solar power tower plant with

Yan LUO, Xiaoze DU, Lijun YANG, Chao XU, Muhammad AMJAD

《能源前沿（英文）》 2017年第11卷第4期页码 461-471 doi: 10.1007/s11708-017-0503-5

摘要： Solar multiple (SM) and thermal storage capacity are two key design parameters for revealing the performance of direct steam generation (DSG) solar power tower plant. In the case of settled land area, SM and thermal storage capacity can be optimized to obtain the minimum levelized cost of electricity (LCOE) by adjusting the power generation output. Taking the dual-receiver DSG solar power tower plant with a given size of solar field equivalent electricity of 100 MW in Sevilla as a reference case, the minimum LCOE is 21.77 ￠/kWh with an SM of 1.7 and a thermal storage capacity of 3 h. Besides Sevilla, two other sites are also introduced to discuss the influence of annual DNI. When compared with the case of Sevilla, the minimum LCOE and optimal SM of the San Jose site change just slightly, while the minimum LCOE of the Bishop site decreases by 32.8% and the optimal SM is reduced to 1.3. The influence of the size of solar field equivalent electricity is studied as well. The minimum LCOE decreases with the size of solar field, while the optimal SM and thermal storage capacity still remain unchanged. In addition, the sensitivity of different investment in sub-system is investigated. In terms of optimal SM and thermal storage capacity, they can decrease with the cost of thermal storage system but increase with the cost of power generation unit.

关键词： direct steam generation solar power tower solar multiple thermal energy storage capacity levelized cost of electricity (LCOE)

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下一代太阳能光热电站中熔融氯盐技术研发进展 Review

丁文进, Thomas Bauer

《工程（英文）》 2021年第7卷第3期页码 334-347 doi: 10.1016/j.eng.2020.06.027

摘要：

结合热能储存（TES，以下简称储热）的太阳能光热发电（concentrated solar power, CSP）技术是未来可再生能源系统中最具应用前景的发电技术之一

关键词：太阳能太阳能光热发电（CSP）热能储存（TES）导热流体（HTF）超临界二氧化碳动力循环腐蚀控制

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

《医学前沿（英文）》 2023年第17卷第3期页码 493-502 doi: 10.1007/s11684-022-0946-x

摘要： Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

关键词： ALK fusion next-generation sequencing fluorescence in situ hybridization immunohistochemistry variant allele frequency intratumoral heterogeneity targeted therapy

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Optical performance analysis of an innovative linear focus secondary trough solar concentrating system

Xiliang ZHANG, Zhiying CUI, Jianhan ZHANG, Fengwu BAI, Zhifeng WANG

《能源前沿（英文）》 2019年第13卷第3期页码 590-596 doi: 10.1007/s11708-018-0602-y

摘要： The parabolic trough solar concentrating system has been well developed and widely used in commercial solar thermal power plants. However, the conventional system has its drawbacks when connecting receiver tube parts and enhancing the concentration ratio. To overcome those inherent disadvantages, in this paper, an innovative concept of linear focus secondary trough concentrating system was proposed, which consists of a fixed parabolic trough concentrator, one or more heliostats, and a fixed tube receiver. The proposed system not only avoids the end loss and connection problem on the receiver during the tracking process but also opens up the possibility to increase the concentration ratio by enlarging aperture. The design scheme of the proposed system was elaborated in detail in this paper. Besides, the optical performance of the semi and the whole secondary solar trough concentrator was evaluated by using the ray tracing method. This innovative solar concentrating system shows a high application value as a solar energy experimental device.

关键词： secondary parabolic trough solar concentrator ray tracing method linear focus concentration ratio optical performance

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新一代成像技术——通过多色显微术拓展对肝脏生物学和肝病的认知

Felix Heymann, Adrien Guillot, Moritz Peiseler, Frank Tacke

《工程（英文）》 2022年第9卷第2期页码 17-21 doi: 10.1016/j.eng.2021.06.015

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Efficient use of waste heat and solar energy: Technologies of cooling, heating, power generation and

Ya-Ling HE, Ruzhu WANG, Anthony Paul ROSKILLY, Peiwen LI

《能源前沿（英文）》 2017年第11卷第4期页码 411-413 doi: 10.1007/s11708-017-0525-z

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Effectively cultivate the next generation of competent Chinese physicians: a perspective from a physician

Zongyu John CHEN,

《医学前沿（英文）》 2010年第4卷第4期页码 473-476 doi: 10.1007/s11684-010-0290-4

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堆石混凝土坝概述及下一代混凝土坝施工技术展望 Review

Feng Jin, Duruo Huang, Michel Lino, Hu Zhou

《工程（英文）》 2024年第32卷第1期页码 100-106 doi: 10.1016/j.eng.2023.09.020

摘要：

Over the past few decades, one of the most significant advances in dam construction has been the invention of the rock-filled concrete (RFC) dam, which is constructed by pouring high-performance selfcompacting concrete (HSCC) to fill the voids in preplaced large rocks. The innovative use of large rocks in dam construction provides engineers with a material that requires less cement consumption and hydration heat while enhancing construction efficiency and environmental friendliness. However, two fundamental scientific issues related to RFC need to be addressed: namely, the pouring compactness and the effect of large rocks on the mechanical and physical properties of RFC. This article provides a timely review of fundamental research and innovations in the design, construction, and quality control of RFC dams. Prospects for next-generation concrete dams are discussed from the perspectives of environmental
friendliness, intrinsic safety, and labor savings.

关键词： Rock-filled concrete dam Pouring compactness Effect of large rocks Intelligent quality control Unmanned dam construction