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Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned

Linjie Wang, Zhili Li, Cheng Tan, Shujuan Liu, Jianfeng Zhang, Siyang He, Peng Zou, Weibo Liu, Yinghui Li

《医学前沿（英文）》 2019年 第13卷 第2期   页码 202-212 doi: 10.1007/s11684-017-0587-7

摘要： The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness.

关键词： countermeasure     physiological effects of weightlessness     effect evaluation     long-term manned spaceflight    

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CLA的生理活性和应用前景

张根旺,郭诤,杨天奎

《中国工程科学》 2001年 第3卷 第7期   页码 85-89

摘要：

CLA是20世纪80年代末才被发现具有许多重要生理活性的天然脂肪酸，文章讨论了CLA的涵义界定、天然存在、重要的生理活性及其应用前景。

关键词： CLA     生理活性     应用前景    

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Chromium phytoextraction and physiological responses of the hyperaccumulator Swartz to plant growth-promoting

《环境科学与工程前沿（英文）》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1609-0

摘要：

● Improved Cr phytoextration efficiency was achieved by B. cereus inoculation.

关键词： Hexavalent chromium     Hyperaccumulator     Rhizobacteria     Leersia hexandra Swartz     Bacillus cereus     Consortia    

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Imaging technologies for plant high-throughput phenotyping: a review

Yong ZHANG, Naiqian ZHANG

《农业科学与工程前沿（英文）》 2018年 第5卷 第4期   页码 406-419 doi: 10.15302/J-FASE-2018242

摘要：

Phenomics studies a variety of phenotypic plant traits and is the key to understanding genetic functions and environmental effects on plants. With the rapid development of genomics, many plant phenotyping platforms have been developed to study complex traits related to the growth, yield, and adaptation to biotic or abiotic stress, but the ability to acquire high-throughput phenotypic data has become the bottleneck in the study of plant genomics. In recent years, researchers around the world have conducted extensive experiments and research on high-throughput, image-based phenotyping techniques, including visible light imaging, fluorescence imaging, thermal imaging, spectral imaging, stereo imaging, and tomographic imaging. This paper considers imaging technologies developed in recent years for high-throughput phenotyping, reviews applications of these technologies in detecting and measuring plant morphological, physiological, and pathological traits, and compares their advantages and limitations.

关键词： high-throughput phenotyping     imaging technology     morphological traits     pathological traits     physiological traits    

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Research progress and prospects of complete ammonia oxidizing bacteria in wastewater treatment

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1555-2

摘要：

• Comammox bacteria have unique physiological characteristics.

关键词： Complete ammonia oxidizing (comammox) bacteria     Nitrogen cycle     Physiological characteristics     Wastewater treatment    

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Translocation and biotoxicity of metal (oxide) nanoparticles in the wetland-plant system

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1432-4

摘要：

• Aquatic plants are more likely to absorb TiO2 NPs that are beneficial to them.

关键词： Constructed wetlands     Aquatic plants     Nanoparticles     Physiological activity     Biomass    

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Physiological functions and clinical implications of the N-end rule pathway

null

《医学前沿（英文）》 2016年 第10卷 第3期   页码 258-270 doi: 10.1007/s11684-016-0458-7

摘要：

The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein’s half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.

关键词： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders     Johanson–Blizzard syndrome    

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Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance

《环境科学与工程前沿（英文）》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1471-x

摘要：

• Hg bioaccumulation by phytoplankton varies among aquatic ecosystems.

关键词： Plankton     Hg bioaccumulation     Physiological characteristics     A cross-system analysis     Nutrient compositions     Global data set    

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.

关键词： PM2.5     Health effects     Integrated exposure-response model     Shijiazhuang    

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基于一种全新的优化多变量非等距模型对中国汉族成人左心室多普勒超声心动图测值生理性变异的校正方法 Article

姚桂华, 陈湘云, 杨文静, 张青, 刘静, 梁欢, 孙慧, 许耀, 王丽, 徐金锋, 张澄, 孙丰荣, 张梅, 曾雪迎, 张运

《工程（英文）》 2022年 第16卷 第9期   页码 115-122 doi: 10.1016/j.eng.2021.05.007

摘要：

多数左心室（LV）多普勒超声心动图参数测值随年龄和性别显著变化，因此有必要对其生理性差异进行校正。本研究旨在验证：不同的多普勒参数测值与生物学特征变量间呈异速非线性相关，且其校正常数与校正指数各不同。共测量了1224名健康成人的23个LV多普勒参数。随机选择70%数据（A组）建立优化多变量非线性模型（OMAM），在30%数据（B组）和183名超重人群数据（C组）中验证OMAM的可靠性，并与基于体表面积（BSA）的单变量等距模型（SVIM）进行比较。结果显示，校正前，23个LV多普勒参数均与一个或多个生物学特征变量显著相关，B组中47.8% (11/23)的参数存在性别间差异，经OMAM校正后，81.8% (9/11)的参数消除了性别间差异。OMAM对B组和C组数据的校正成功率分别为100% (23/23)和82.6% (19/23)，建立了独立于生物学特征变量的多普勒参数的OMAM参考值，而基于BSA的SVIM校正成功率为零。不同的LV多普勒参数与一个或多个生物学特征变量呈异速非线性相关；本研究建立的OMAM成功校正了因生物学特征变量差异对健康和超重人群多普勒测值的生理性影响，其校正效果显著优于传统的SVIM。然而，OMAM针对其他种族、肥胖和疾病状态人群的适用性仍需进一步探究

关键词： 多普勒超声心动图     生理性变异     非等距模型     正常参考值    

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Synergistic effects of sodium hypochlorite disinfection and iron-oxidizing bacteria on early corrosion

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1506-3

摘要：

• The early corrosion process in the cast iron pipes was investigated.

关键词： Cast iron pipe corrosion     Drinking water distribution systems     Chlorine disinfection     Iron-oxidizing bacteria     Coupling effects    

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Investigation of effects of Cocamide Diethanolamide chemical on physical and rheological properties of

《结构与土木工程前沿（英文）》 2022年 第16卷 第1期   页码 99-116 doi: 10.1007/s11709-021-0799-4

摘要： In this study, bituminous binder was modified with Cocamide Diethanolamide chemical, a non-ionic surfactant, and the physical and rheological properties of modified binders were investigated. In addition, Cocamide Diethanolamide has been used for the first time to modify bituminous binder, and this situation makes the study distinctive. Bituminous binder was modified more than once with the chemical by changing modification parameters and using certain additive ratios (1%, 3%, and 5%). The effects of different modification parameters and chemical additive on modified samples were investigated with conventional bitumen tests (softening point, penetration, ductility) and Superpave tests (rotational viscometer, rolling thin film oven test, pressure aging vessel, dynamic shear rheometer, bending beam rheometer). In addition, the structural characteristics of the reference binder and modified samples were examined by X-ray diffraction, Fourier Transform Infrared Spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. The examinations showed that Cocamide Diethanolamide softens bituminous binder and lowers processing temperatures. In addition, compared to reference binder, rutting resistances of modified bituminous binders decreased with the increase of additive ratio. However, modification with Cocamide Diethanolamide increased the resistance to fatigue cracks and thermal cracks.

关键词： Cocamide Diethanolamide     bitumen modification     rheology     Superpave tests    

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Protective effects of lignin fractions obtained from grape seeds against bisphenol AF neurotoxicity viaantioxidative effects mediated by the Nrf2 pathway

《化学科学与工程前沿（英文）》 2023年 第17卷 第7期   页码 976-989 doi: 10.1007/s11705-022-2237-0

摘要： Lignin exhibits antioxidative and various other biological properties. However, its neuroprotection capability has rarely been studied. In this study, three types of lignin with different structures were prepared from grape seeds by using different isolation techniques. The antioxidative and neuroprotective effects of the lignin fractions were evaluated with the apoptosis model of murine neuroectodermal (NE-4C) neural stem cells stimulated with bisphenol AF. The results demonstrated that the half maximal inhibitory concentration for scavenging 2,2-diphenyl-1-picrylhydrazyl with water-soluble lignin (L-W, 58.19 μg·mL–1) was lower than those of lignin in the autohydrolyzed residue of grape seeds (84.27 μg·mL–1) and original lignin in grape seeds (99.44 μg·mL–1). BPAF exposure had negative effects on the reactive oxygen species, malondialdehyde content, and superoxide dismutase and glutathione peroxidase activities in NE-4C cells, which can be reversed by using the prepared lignin to reduce oxidative stress. An immunofluorescence assay demonstrated that grape seed lignin induced protective effects on BPAF-injured NE-4C cells via the nuclear factor erythroid 2-related Factor 2 pathway. In addition, correlational analyses showed that lignin (L-W) with lower molecular weights and noncondensed phenolic hydroxyl group content and higher contents of COOH groups effectively prevented cell apoptosis, scavenged reactive oxygen species, and ensured protection from nerve injury. This study demonstrated that grape seed lignin can be used as a neuroprotective agent and serves as a demonstration of active lignin production from grape seed waste.

关键词： grape seed lignin     structure     antioxidant     NE-4C cells     neuroprotection    

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Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems:

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1495-2

摘要：

• Quorum sensing enhancement and inhibition methods are summarized.

关键词： Quorum sensing     Biological waste treatment     Biofilm formation    

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Seismic effects on reinforcement load and lateral deformation of geosynthetic-reinforced soil walls

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 1001-1015 doi: 10.1007/s11709-021-0734-8

摘要： Current design methods for the internal stability of geosynthetic-reinforced soil (GRS) walls postulate seismic forces as inertial forces, leading to pseudo-static analyses based on active earth pressure theory, which yields unconservative reinforcement loads required for seismic stability. Most seismic analyses are limited to the determination of maximum reinforcement strength. This study aimed to calculate the distribution of the reinforcement load and connection strength required for each layer of the seismic GRS wall. Using the top-down procedure involves all of the possible failure surfaces for the seismic analyses of the GRS wall and then obtains the reinforcement load distribution for the limit state. The distributions are used to determine the required connection strength and to approximately assess the facing lateral deformation. For sufficient pullout resistance to be provided by each reinforcement, the maximum required tensile resistance is identical to the results based on the Mononobe–Okabe method. However, short reinforcement results in greater tensile resistances in the mid and lower layers as evinced by compound failure frequently occurring in GRS walls during an earthquake. Parametric studies involving backfill friction angle, reinforcement length, vertical seismic acceleration, and secondary reinforcement are conducted to investigate seismic impacts on the stability and lateral deformation of GRS walls.

关键词： geosynthetics     reinforced soil     retaining walls     seismic performance    

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标题 作者 时间 类型 操作

Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned

Linjie Wang, Zhili Li, Cheng Tan, Shujuan Liu, Jianfeng Zhang, Siyang He, Peng Zou, Weibo Liu, Yinghui Li

期刊论文

CLA的生理活性和应用前景

张根旺,郭诤,杨天奎

期刊论文

Chromium phytoextraction and physiological responses of the hyperaccumulator Swartz to plant growth-promoting

期刊论文

Imaging technologies for plant high-throughput phenotyping: a review

Yong ZHANG, Naiqian ZHANG

期刊论文

Research progress and prospects of complete ammonia oxidizing bacteria in wastewater treatment

期刊论文

Translocation and biotoxicity of metal (oxide) nanoparticles in the wetland-plant system

期刊论文

Physiological functions and clinical implications of the N-end rule pathway

null

期刊论文

Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance

期刊论文

Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

期刊论文

基于一种全新的优化多变量非等距模型对中国汉族成人左心室多普勒超声心动图测值生理性变异的校正方法

姚桂华, 陈湘云, 杨文静, 张青, 刘静, 梁欢, 孙慧, 许耀, 王丽, 徐金锋, 张澄, 孙丰荣, 张梅, 曾雪迎, 张运

期刊论文

Synergistic effects of sodium hypochlorite disinfection and iron-oxidizing bacteria on early corrosion

期刊论文

Investigation of effects of Cocamide Diethanolamide chemical on physical and rheological properties of

期刊论文

Protective effects of lignin fractions obtained from grape seeds against bisphenol AF neurotoxicity viaantioxidative effects mediated by the Nrf2 pathway

期刊论文

Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems:

期刊论文

Seismic effects on reinforcement load and lateral deformation of geosynthetic-reinforced soil walls

期刊论文