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《医学前沿(英文)》 2022年 第16卷 第2期 页码 227-239 doi: 10.1007/s11684-021-0896-8
关键词: cannabidiol depression radial neural stem cells neurogenesis
Physiological functions and clinical implications of the N-end rule pathway
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 258-270 doi: 10.1007/s11684-016-0458-7
The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein’s half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.
关键词: N-end rule pathway Ate1 cardiovascular development neurogenesis spermatogenesis neurodegenerative disorders Johanson–Blizzard syndrome
杨朝阳, 赵文, 高钰丹, 段红梅, 郝鹏, 郝飞, 李晓光
《工程(英文)》 2021年 第7卷 第12期 页码 1713-1714 doi: 10.1016/j.eng.2021.09.009
标题 作者 时间 类型 操作
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
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